Abstract
The levels of cholesterol in the fore, mid and hind brain regions were determined in normal and Pars distalis ablatedRana cyanophlictis, at various time intervals after the operation. The time course of the effects of removal of Pars distalis showed an initial overshoot (shock effect) and a recovery phase leading to a new stabilized stage. In general ablation of Pars distalis resulted in the elevation of the levels of cholesterol during the first week after the operation (P>0·05, 0·001 and 0·001 for the fore, mid and hind brain on the first day after the operation). Regional differences in the magnitude of response were significant. A possible relationship between adrenal steroids and thyroid hormones and cholesterol synthesis is suggested.
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Nayeemunnisa, Sheela Rani, C.S. Physiological studies on the effects of hormonal imbalance on the CNS. Proc. Indian Acad. Sci. 84, 95–100 (1976). https://doi.org/10.1007/BF03045586
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DOI: https://doi.org/10.1007/BF03045586