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B cell activation in patients with rheumatic disease: association with an increased ratio of Th2: Th1 cytokine secreting cells

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Japanese Journal of Rheumatology

Abstract

This minireview examines the pattern of Th1 and Th2 cytokine-secreting cells present in the peripheral blood of patients with rheumatic diseases including lupus, myositis, Sjögren’s syndrome and rheumatoid arthritis. The general conclusion is reached that diseases marked by increased B cell activation are characterized by a relative increase in the frequency of peripheral blood mononuclear cells secreting Th2 versus Th1 cytokines.

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References

  1. Mosmann TR, Coffman RL: Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties.Annu Rev Immunol 7: 147–171, 1989.

    Article  Google Scholar 

  2. Mosmann TR, Cherwinski H, Bond MWet al.: Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins.J Immunol 136: 2348–2357, 1986.

    CAS  PubMed  Google Scholar 

  3. Moore KW, Vieira P, Fiorentino DRet al.: Homology of cytokine synthesis inhibitory factor (IL-10) to the EBV gene BCRF1.Science 248: 1230–1234, 1990.

    Article  CAS  PubMed  Google Scholar 

  4. Tanaka T, Hu-Li J, Seder RAet al.: IL-4 suppresses IL-2 and IFN-γ production by naive T cells stimulated by accessory cell-dependent receptor engagement.Proc Natl Acad Sci USA 90: 5914–5918, 1993.

    Article  CAS  PubMed  Google Scholar 

  5. Seder RA, Paul WE, Mark MDet al.: The presence of IL-4 during in vitro proming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.J Exp Med 176: 1091–1098, 1992.

    Article  CAS  PubMed  Google Scholar 

  6. Parronchi P, DeCarli M, Manetti Ret al.: IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.J Immunol 149: 2977–2983, 1992.

    CAS  PubMed  Google Scholar 

  7. Shirai A, Conover J, Klinman DM: Increased activation and altered ratio of IFNg: IL-4 secreting cells in MRL/lpr mice.Autoimmunity 21: 107–116, 1996.

    Article  Google Scholar 

  8. Takahashi S, Fossati L, Owamoto Met al.: Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.J Clin Invest 97: 1597–1604, 1996.

    Article  CAS  PubMed  Google Scholar 

  9. Steinberg AD, Klinman DM: Pathogenesis of systemic lupus erythematosus.Rheum Dis Clin N Am 14: 25–41, 1988.

    CAS  Google Scholar 

  10. Klinman DM, Steinberg AD: Systemic autoimmune disease arises from polyclonal B cell activation.J Exp Med 165: 1755–1760, 1987.

    Article  CAS  PubMed  Google Scholar 

  11. Klinman DM, Eisenberg RA, Steinberg AD: Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice.J Immunol 1440: 506–512, 1990.

    Google Scholar 

  12. Linker-Israeli M, Deans R, Wallace Det al.: Elevated levels of endogenous IL-6 in systemic lupus erythematosus.J Immunol 147: 117–123, 1991.

    CAS  PubMed  Google Scholar 

  13. Kitani A, Hara M, Hirose Tet al.: Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression.Clin Exp Immunol 88: 75–83, 1992.

    Article  CAS  PubMed  Google Scholar 

  14. Nagafuchi H, Suzuki N, Mizushima Yet al.: Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus.J Immunol 151: 6525–6534, 1993.

    CAS  PubMed  Google Scholar 

  15. Kitani A, Hara M, Hirose Tet al.: Heterogeneity of B cell responsiveness to interleukin 4, interleukin 6 and low molecular weight B cell growth factor in discrete stages of B cell activation in patients with systemic lupus erythematosus.Clin Exp Immunol 77: 31–36, 1989.

    CAS  PubMed  Google Scholar 

  16. Spronk P, Ter Borg E, Limburg Pet al.: Plasma concentration of IL-6 in systemic lupus erythematosus; an indicator of disease activity?Clin Exp Immunol 90: 106–110 1992.

    CAS  PubMed  Google Scholar 

  17. Al-Janadi M, Al-Balla S, Al-Dalaan Aet al.: Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis and other rheumatic diseases.J Clin Immunol 13: 58–67, 1993.

    Article  CAS  PubMed  Google Scholar 

  18. Hagiwara E, Gourley M, Lee Set al.: Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of IL-10: IFNgamma secreting cells in the peripheral blood.Arthritis Rheum 39: 379–385, 1996.

    Article  CAS  PubMed  Google Scholar 

  19. Briere F, Servet-Delprat C, Bridon Jet al.: Human interleukin-10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.J Exp Med 179: 757–762, 1994.

    Article  CAS  PubMed  Google Scholar 

  20. Llorente L, Zou W, Levy Yet al.: Role of IL-10 in the B lymphocyte hyperactivity and autoantibody production of human SLE.J Exp Med 181: 839–844, 1995.

    Article  CAS  PubMed  Google Scholar 

  21. Llorente L, Richaud-Patin Y, Wijdenes Jet al.: Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus.Eur Cytokine Netw 4: 421–430, 1993.

    CAS  PubMed  Google Scholar 

  22. Houssiau FA, Lefebvre C, Vanden Berghe Met al.: Serum IL-10 titers in SLE reflect disease activy.Lupus 4: 393–395, 1995.

    Article  CAS  PubMed  Google Scholar 

  23. Richaud-Patin R, Alcocer-Varela J, Llorente L: High levels of Th2 cytokine gene expression in SLE.Rev Invest Clin 47: 267–272, 1995.

    CAS  PubMed  Google Scholar 

  24. Kroemer G, Martinez-a C: Short Analytical review: cytokines and autoimmune disease.Clin Immunol Immunopathol 61: 275–295, 1991.

    Article  CAS  PubMed  Google Scholar 

  25. Goldman M: Review: cytokines in the pathogenesis of systemic lupus erythematosus.Autoimmunity 8: 173–179, 1990.

    Article  CAS  PubMed  Google Scholar 

  26. Horwitz DA, Wang H, Gray JD: Cytokine gene profiles in circulating blood mononuclear cells from patients with SLE: Increased IL-2 but not IL-4 mRNA.Lupus 3: 423–428, 1994.

    Article  CAS  PubMed  Google Scholar 

  27. Huang YP, Perrin LH, Miescher PAet al.: Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.J Immunol 141: 827–833, 1988.

    CAS  PubMed  Google Scholar 

  28. Hagiwara E, Abbasi F, Mor Get al.: Phenotype and frequency of cells secreting IL-2, IL-4, IL-6 IL-10, IFNg and TNFa in human peripheral blood.Cytokine 7: 815–822, 1995.

    Article  CAS  PubMed  Google Scholar 

  29. Hagiwara E, Adams EM, Plotz PHet al.: Abnormal cytokine production by peripheral blood mononuclear cells from patients with polympositis and dermatomyositis.Clin Exp Rheum 14: 485–491, 1996.

    CAS  Google Scholar 

  30. Feldman M, Brennan FM, Chantry Det al.: Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.Immunol Rev 119: 105–123, 1991.

    Article  Google Scholar 

  31. Firestein GS, Alvaro-Gracia J, Maki R: Quantitative analysis of cytokine gene expression in rheumatoid arthritis.J Immunol 144: 3347, 1990.

    CAS  PubMed  Google Scholar 

  32. Miyasaka N, Sato K, Goto M: Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients: possible involvement in joint destruction.Arthritis Rheum 31: 480, 1988.

    Article  CAS  PubMed  Google Scholar 

  33. Fong K, Boey M, Koh Wet al.: Cytokine concentration in the synovial fluid and plasma of rheumatoid arthritis patients: correlation with bony erosions.Clin Exp Rheum 12: 55–58, 1994.

    CAS  Google Scholar 

  34. Hirano T, Matsuda T, Turner Met al.: Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.Eur J Immunol 18: 1797–1801, 1988.

    Article  CAS  PubMed  Google Scholar 

  35. Schulze-Koops H, Lipsky PE, Kavanaugh AFet al.: Elevated Th1 or Th0-like cytokine mRNA in periphal circulation of patients with rheumatoid arthritis.J Immunol 155: 5029–5037, 1995.

    CAS  PubMed  Google Scholar 

  36. Quayle AJ, Chomarat P, Miossex Pet al.: Rheumatoid inflammatory T cell clones express mostly Th1 but also Th2 and mixed (Th0-like) cytokine patterns.Scand J Immunol 38: 75–82, 1993.

    Article  CAS  PubMed  Google Scholar 

  37. Wolf RE, Baethge BA: IL-1, IL-2 and soluble IL-2R in polymyositis.Arthritis Rheum 33: 1007–1014, 1990.

    Article  CAS  PubMed  Google Scholar 

  38. Mantegazza R, Bernasconi P: Cellular aspects of myositis.Curr Opin Rheum 6: 568–574, 1994.

    Article  CAS  Google Scholar 

  39. Villarreal GM, Alcocer-Varela J, Llorente L: Cytokine gene and CD25 antigen expression in peripheral blood T cells from patients with primary Sjögren’s syndrome.Autoimmunity 20: 223–229, 1995.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. First Department of Internal Medicine, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-Ku, 236, Yokohama, Japan

    Eri Hagiwara & Yoshiaki Ishigatsubo

  2. Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, 20892, Bethesda, MD, USA

    Dennis M. Klinman

Authors
  1. Eri Hagiwara
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  2. Yoshiaki Ishigatsubo
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  3. Dennis M. Klinman
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Hagiwara, E., Ishigatsubo, Y. & Klinman, D.M. B cell activation in patients with rheumatic disease: association with an increased ratio of Th2: Th1 cytokine secreting cells. Japanese Journal of Rheumatology 7, 145–152 (1997). https://doi.org/10.1007/BF03041236

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  • DOI: https://doi.org/10.1007/BF03041236

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