Summary
The cardiovascular effects of two premedication regimes used in paediatric anaesthesia were studied. Eleven patients received rectal methohexitone (22 mg·kg) and 11 patients received intramuscular Innovar® (0.03 ml · kg). The effect of these drugs on ventricular function was evaluated by measuring the shortening of the left ventricular minor dimension by echocardiography. No significant changes in this dimension, blood pressure, heart rate or respiratory rate were demonstrated with either drug.
Both rectal methohexitone and intramuscular Innovar® were shown to have minimal cardiovascular effects when used as preoperative sedation in paediatric patients. Echocardiography proved to be a valuable technique for the noninvasive evaluation of drug effects on myocardial contractility in children.
Résumé
Nous avons étudié les effets cardiovasculaires de deux prémédications utilisées en pédiatrie. Onze enfants ont reçu du méthohexital par voie rectale (22 mg/kilo) et 11 autres ont reçu par voie intra-musculaire de l’Innovar®, à raison de 0.03 ml/kg. L’effet de ces médicaments sur la fonction ventriculaire a été évalué par la mesure du raccourcissement du diamètre transverse du ventricule gauche à l’échocardiographie.
On n’a observé aucun changement significatif de ce diamètre, de la pression artérielle, des fréquences cardiaques et respiratoires, à la suite de l’administration de l’une ou de l’autre des prémédications étudiées. Le méthohexital rectal et l’Innovar® intra-musculaire utilisés comme sédatifs pré-opératoires en pédiatrie ont des effets dépresseurs minimes sur le système car-diovasculaire. L’échocardiographie s’est avérée une technique non-invasive utile pour l’étude des effets des médicaments sur la contractilité myocardique chez l’enfant.
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Maguire, H.T., Webb, G.E., Rees, A.H. et al. Noninvasive evaluation of cardiovascular effects of preoperative sedation in children. Canad. Anaesth. Soc. J. 26, 29–33 (1979). https://doi.org/10.1007/BF03039450
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DOI: https://doi.org/10.1007/BF03039450