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Studies on penetration of peroral new quinolone, levofloxacin to rabbit oral soft tissues with influence of stomachics sankyo magen mittel

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Abstract

It is a well-known fact that theoretically the absorption of new quinolones in the intestinal tract is significantly inhibited as a result of their interaction with metal cations. In order to study the effects of S. M powder, which is frequently used in the department of dentistry, on the tissue transfer of new quinolones, we administered S. M powder in combination with levofloxacin (LVFX) to rabbits and made comparative studies of soft tissue transfer rates. Prior to the initiation of the present study, we confirmed that there is a significant difference in tissue transfer rates of ofloxacin (OFLX) and LVFX, based upon the fact that LVFX is an optical activator of the OFLX. We obtained the following results in this study:

  1. 1)

    All the samples including the serum and tissue specimens collected from the LVFX single administration group reached Tmax 0.33–0.82 hours later than those collected from the OFLX single administration groups showed

  2. 2)

    Although the serum samples collected from the LVFX and OFLX single administration groups showed nearly the equivalent Cmax, all tissue samples collected from the LVFX single administration group showed higher transfer rates than those collected from the OFLX single administration group.

  3. 3)

    All the samples including the serum and tissue specimens collected from the S. M powder combination group showed lower values of Cmax and AUC than those collected from the LVFX single administration group.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery I, The Nippon Dental University School of Dentistry at Tokyo, Tokyo, Japan

    Yohsuke Iwashige & Tazuko Satoh

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  1. Yohsuke Iwashige
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  2. Tazuko Satoh
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Iwashige, Y., Satoh, T. Studies on penetration of peroral new quinolone, levofloxacin to rabbit oral soft tissues with influence of stomachics sankyo magen mittel. Shigaku = Odontology 85, 408–418 (1997). https://doi.org/10.1007/BF03039037

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