Abstract
Synergistic antiparkinsonian actions of different classes of putative therapeutic agents co-administered with a subthreshold dose of L-3,4-dihydroxy-phenylalanine (L-Dopa) (5mg/kg) in drug-naive l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mice as well as the restorative actions of those compounds in suprathreshold L-Dopa-tolerant MPTP-treated mice subjected to “wearing-off” of L-Dopa efficacy were assessed in a series of experiments. The classes of compounds studied included the noncompetitive NMDA antagonists, memantine, amantadine and MK-801, the anticonvulsive and putative anticonvulsive agents, lamotrigine, FCE 26743, phenytoin, the monoamine oxidase inhibitors, L-Deprenyl, amiflamine, α-ethyltryptamine, clorgyline and phenelzine, and the α2-adrenoceptor agonists, clonidine and guanfacine. In this final case, the restorative effects of clonidine and guanfacine were antagonised by the α2-adrenoceptor antagonist, yohimbine, but not the α1-adrenoceptor antagonist, prazosin. Within each class of potentially therapeutic agents a differential restorative efficacy was obtained, but the combination of different doses of apomorphine with clondine failed to restore motor activity. Finally, the neuroprotective actions of acute and subchronic administration of the nitrone spin-trapping compound, α-phenyl-tert-butyl nitrone upon the spontaneous motor behaviour and striatal dopamine concentrations of MPTP-treated mice was examined.
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Agarwal, J.C., Nath, C, Gupta, G.P., Bhargava, K.P. and Shanker, K. (1981) Anti-Parkinsonian and anticonvulsant activity of some silyl substituted dopamine derivatives.Pharmacological Research Commumications,13, 937–947.
Aminoff, M.J. (1994) Treatment of Parkinson’s disease.Western Journal of Medicine,161, 303–308.
Archer, T. and Fredriksson, A. (1999) Effects of acute/chronic, subthreshold/threshold doses of L-Dopa in MPTP-treated mice: I Influence of competitive and noncompetitive NMDA antagonists. In: Palomo, T., Beninger, R.J. and Archer, T. (Eds.)Interactive Monoaminergic Disorders. Editorial Sintesis, Madrid, pp. 573–606.
Archer, T., Fredriksson, A., Jonsson, G., Lewander, T., Mohammed, A.K., Ross, S.B. and Söderberg, U. (1986) Central noradrenaline depletion antagonizes aspects of d-amphetamine-induced hyperactivity in the rat.Psycho-pharmacology (Ber/.),88, 141–146.
Archer, T., Bassen, M., Peters, D., Luthman, J. and Fredriksson, A. (1996) Dopaminergic-glutamatergic balance in the forebrain: functional studies of movement disorders in rats and mice. In Beninger, R.J., Palomo, T. and Archer, T. (Eds.)Dopamine Disease States. Madrid University Press, Madrid, pp. 117–154.
Azzaro, A.J. and Gutrecht, J.A. (1975) Characteristics of the inhibitory action of diphenylhydantoin on brain monoamine oxidase.Neurology,25, 378–383.
Beal, M.F., Brouillet, E., Jenkins, B.G., Henshaw, D.R., Rosen, B.R. and Hyman, B.T. (1993) Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate.Journal of Neurochemistry,61, 1147–1150.
Beal, M.F., Henshaw, D.R., Jenkins, B.G., Rosen, B.R. and Schulz, J.B. (1994) Coenzyme Q10 and nicotinamide block striatal lesions produced by mitochondrial toxin malonate.Annals of Neurology,36, 882–888.
Bergmann, K.J., Limongi, J.C., Lowe, Y.H., Mendoza, M.R. and Yahr, M.D. (1984) Potentiation of the “dopa” effect in parkinsonism by a direct GABA receptor agonist (letter).Lancet,1, 559.
Berlan, M., Rascol, O.et al. (1989) Alpha 2-adrenergic sensitivity in Parkinson’s disease.Clinical Neuropharmacology,12, 138–144.
Birkmayer, W., Riederer, P.M., Youdim, M.P.H. and Linauer, W. (1975) The potentiation of the anti-kinetic effect afier L- DOPA treatment by an inhibitor of MAO-B, deprenyl.Journal of Neural Transmission,36, 303–326.
Birkmayer, W., Knoll, J., Riderer, P. and Youdim, M.B.T. (1983) (-)Deprenyl leads to prolongation of L-DOPA efficacy in Parkinson’s disease.Mod Problems in Pharmacopsychiatrv,19, 170–176.
Björk, L., Cornfield, L.J., Nelson, D.L., Hillver, S.-E., Andén, N.-E., Lewander, T. and Hacksell, U. (1991) Pharmacology of the novel 5-hydroxytryptamine 1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetra- lin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin- induced effects.Journal of Pharmacology and Experimental Therapeutics,258, 58–65.
Burns, R., Chiueh, C, Markey, S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J. (1983) A primate model of parkinsonism: selective destruction of dopami- nergic neurons in the pars compacta on the substantia nigra by N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine.Proceedings of the National Academy of Sciences, USA,80, 4546–4550.
Calne, D.B., Langston, J.W., Martin, W.R.W., Stoessl, A.J., Ruth, T.J., Adam, M.J., Pate, B.D. and Schulzer, M. (1985) Positron emission tomography after MPTP: observations relating to the cause of Parkinson’s disease.Nature,317, 246–248.
Carey, R.J. (1991) Chronic L-Dopa treatment in the unilateral 6-OHDA rat: evidence for behavioural sensitiza- tion and biochemical tolerance.Brain Research,568, 205–214.
Carlsson, M. and Carlsson, A. (1989a) Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice.Journal of Neural Transmission,77, 65–71.
Carlsson, M. and Carlsson, A. (1989b) Marked motor stimulation in monoamine-depleted mice following treatment with atropine in combination with clonidine.Journal of Neural Transmission: Parkinson’s Disease and Dementia Section,1, 317–322.
Carlsson, M. and Carlsson, A. (1990a) Interfering with glutamatergic neurotransmission by means of NMDA antagonist administration discloses the locomotor stimulatory potential of other transmitter systems.Pharmacology, Biochemistry and Behaviour,36, 45–50.
Carlsson, M. and Carlsson, A. (1990b) The non-competitive NMDA antagonists MK-801 and PCP, as well as the competitive NMDA antagonist SDZ EAA494 (D-CPPene), interact synergistically with clonidine to promote locomotion in monoamine-depleted mice.Life Sciences,47, 1729–1736.
Carney, J.M. and Floyd, R.A. (1991) Protection against oxida- tive damage to CNS by alpha-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: a novel series of nonlipid free radical scavengers.Journal of Molecular Neuroscience,3, 47–57.
Carrillo, M.-C, Kanai, S., Nokubo, M. and Kitani, K. (1991) (-)-Deprenyl induces activities of both Superoxide dismu- tase and catalase but not of glutathione peroxidase in the striatum of young male rats.Life Sciences,48, 517–521.
Cash, R., Ruberg, M.et al. (1984) Adrenergic receptors in Parkinson’s disease.Brain Research,322, 269–275.
Chen, G., Bray, T.M., Janzen, E.G. and McCay, P.B. (1990) Execretion, metabolism and tissue distribution of a spin trapping agent, α-phenyl-N-tert-butylnitrone (PBN) in rats.Free Radical Research Communication,9, 317–323.
Chen, H.S. and Lipton, S.A. (1997) Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism.Journal of Physiology (Lond.),499, 27–46.
Cheng, H.Y., Liu, T., Feuerstein, G. and Barone, F.C. (1993) Distribution of spin-trapping compounds in rat blood and brain:in vivo microdialysis determination.Free Radicals in Biology and Medicine,14, 243–250.
Chow, M.L. and Hendley, CD. (1959) Effect of monoamine inhibitors on experimental convulsions.Federal Proceedings,18, 376.
Clough-Helfman, C. and Phillis, J.W. (1991) The free radical trapping agent N-tert-butyl-alpha-phenylnitrone (PBN) attenuates cerebral ischemic injury in gerbils.Free Radical Research Communications,15, 177–186.
Colombo, M, Strolin Benedetti, M., Bonsignori, A., Cocchiara, G., Roncucci, R. and Dostert, P. (1990) MAO activity, metabolism and anticonvulsant activity of milacemide in rats and mice.Journal of Neural Transmission,32(Suppl.), 123–129.
Da Prada, M. (1991) New approaches to the treatment of age- related brain disorders.Canadian Journal of Neurological Science,18, 384–386.
Danysz, W., Parsons, CG., Kornhuber, J., Schmidt, W.J. and Quack, G. (1997) Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies.Neuroscience and Biobehavioral Reviews,21, 455–468.
Davis, G.C, Williams, A.C., Markey, S.P., Ebert, M.H., Caine, E.D., Reichert, CM. and Kopin, I.J. (1979) Chronic parkinsonism secondary to intravenous injection of meperidine analogues.Psychiatry Research,1, 249–254.
Di Monte, DA, DeLanney, LE, Irwin, I, Royland, JE, Chan, P, Jakowec, MW and Langsten, JW (1996) Monoamine oxidase- dependent metabolism of dopamine in the striatum and substantia nigra of L-DOPA-treated monkeys.Brain Research,738, 53–59.
Dolphin, A.C., Jenner, P.et al. (1976) The relative importance of dopamine and noradrenaline receptor stimulation for the restoration of motor activity in reserpine or alpha- methyl-p-tyrosine pre-treated mice.Pharmacology, Biochemistry and Behaviour,4, 661–670.
Dostert, P., Strolin Benedetti, M. and Tipton, K.F. (1991) New anticonvulsants with selective MAO-B inhibitory activity.European Journal of Neuropharmacology,1, 317–319.
Drago, F., Continella, G., Spadaro, F., Cavaliere, S. and Scapagnini, U. (1986) Behavioral effects of deprenyl in aged rats.Functional Neurology,1, 165–174.
Duvoisin, R.C., Heikkila, R.E., Nicklas, W.J. and Hess, A. (1986) Dopaminergic neurotoxicity of MPTP in the mouse: a murine model of parkinsonism. In Fahn, S. (Ed.)Recent Developments. Parkinson’s Disease. Raven Press, New York, pp. 147–156.
Ebert, U. and Löscher, W. (1999) Monoamine interactions in animal models of epilepsy. In Palomo, T., Beninger, R.J. and Archer, T. (Eds.)Interactive Monoaminergic Disorders. Editorial Sintesis, Madrid, Spain, pp. 555–572.
Engber, T.M., Papa, S.M., Boldry, R.C. and Chase, T.N. (1994) NMDA receptor blockade reverses motor response alterations induced by levodopa.Neuroreport,5, 2586–2588.
Engberg, G., Elebring, T. and Nissbrandt, H. (1991) Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons.Journal of Pharmacology and Experimental Therapeutics,259, 841–847.
Eshel, G., Ross, S.B.et al. (1990) Alpha 1 (but not alpha 2)- adrenoceptor agonists in combination with the dopamine D2 agonist quinpirole produce locomotor stimulation in dopamine-depleted mice.Pharmacology and Toxicology,67, 123–131.
Fang, J. and Yu, PH. (1994) Effect of L-Deprenyl, its structural analogues and some monoamine oxidase inhibitors on dopamine uptake.Neuropharmacology,33, 763–768.
Fadda, E.W and Danysz, W. (1988) Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.Neuropharmacology,27, 1183–1185.
Finberg, J.P., Wang, J., Goldstein, D.S., Kopin, I.J. and Bankiewicz, K.S. (1995) Influence of selective inhibition of monoamine oxidase A or B on striatal metabolism of L-Dopa in hemiparkinsonian rats.Journal of Neurochemistry,65, 1213–1220.
Fingerg, J.P.M., Tenne, M. and Youdim, M.B.H. (1981) Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B.British Journal of Pharmacology,73, 65–74.
Fisher, A., Biggs, C.S. and Starr, M.S. (1998) Differential effects of NMDA and non-NMDA antagonists on the activity of aromatic L-amino acid decarboxylase activity in the nigrostriatal dopamine pathway of the rat.Brain Research,792, 126–132.
Floyd, R.A. (1991) Oxidation damage to behavior during aging.Science,254, 1597.
Floyd, R.A. (1993) Basic free radical biochemistry. In Yu, B.P. (Ed.)Free Radicals in Aging, CRC Press, Boca Raton, Florida, pp. 39–55.
Fredriksson, A. and Archer, T. (1994a) MPTP-induced behavioural and biochemical deficits: a paramatric analysis.Journal of Neural Transmission,7, 123–132.
Fredriksson, A. and Archer, T. (1994b) MPTP-induced behavioural deficits in mice: validity and utility of parkinsonism. In Palomo, T., Archer, T. and Beninger, R.J. (Eds.)Strategies for Studying Brain Disorders: Schizopsychotic, Cognitive and Movement Disorders. Farrand and Madrid University Press.
Fredriksson, A. and Archer, T. (1995) Synergistic interactions between COMT/MAO- inhibitors and L-Dopa in MPTP-treated mice.Journal of Neural Transmission,102, 19–34.
Fredriksson, A. and Archer, T. (1999) Effects of acute/chronic, subthreshold/ threshold doses of L-Dopa in MPTP-treated mice: II effects of MAO/COMT inhibitors. In Palomo, T., Beninger, R.J. and Archer, T. (Eds.)Interactive Monoaminergic Disorders. Editorial Sintesis and Cerebro y Mente, Madrid, pp. 607–654.
Fredriksson, A., Plaznik, A., Sundström, E., Jonsson, G. and Archer, T. (1990) MPTP-induced hypoactivity in mice: reversal by L-dopa.Pharmacology and Toxicology,67, 295–301.
Fredriksson, A., Gentsch, C. and Archer, T. (1994a) Synergistic interactions between NMDA-antagonists and L-Dopa on activity in MPTP-treated mice.Journal of Neural Transmission (Gen. Sect.),97, 197–209.
Fredriksson, A., Gentsch, C. and Archer, T. (1994b) Effect of the competitive NMDA antagonist, CGP 40116, and a low dose of L-Dopa on the motor activity deficit of MPTP-treated mice.Behavioural Pharmacology,5, 599–606.
Fredriksson, A., Eriksson, P. and Archer, T. (1997) MPTP- induced deficits in learning and motor activity: Possible neuroprotective effects of the spin trapping agent, α-phenyl- tert-butyl-nitrone (PBN).Journal of Neural Transmission,104, 579–592.
Fredriksson, A., Palomo, T. and Archer, T. (1999) Effects of co-administration of anticonvulsant and putative anticonvulsive agents and sub/supra threshold doses of L-Dopa upon motor behaviour of MPTP-treated mice.Journal of Neural Transmission,106, 889–909.
Fredriksson, A., Palomo, T., Chase, T.N. and Archer, T. (1999) Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists.Journal of Neural Transmission,106, 283–300.
Giovanni, A., Sieber, B.A., Heikkila, R.E. and Sonsalla, P.K. (1991) Correlation between the neostriatal content of the l-methyl-4-phenyl-l,2,3,6-tetrahydropyridinium species and dopaminergic neurotoxicity following l-methyl-4-phe-nyl-l,2,3,6-tetrahydropyridine administration to several strains of mice.Journal of Pharmacology and Experimental Therapeutics,257, 691–697.
Goa, K.L., Ross, S.R. and Chrisp, P. (1993) Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy.Drugs,46, 152–176.
Goldstein, M., Engel, J.et al. (1983) Therapeutic potentials of centrally acting dopamine and alpha 2-adrenoceptor agonists.Journal of Neural Transmission Supplement,18, 257–263.
Goldstein, M. and Lieberman, A. (1992) The role of the regulatory enzymes of catecholamine synthesis in Parkinson’s disease.Neurology,42, 8–12.
Gomez-Mancilla, B., Boucher, R.et al. (1991) Effect of clonidine and atropine on rest tremor in the MPTP monkey model of parkinsonism.Clinical Neuropharmacology,14, 359–366.
Goodwin, P., Starr, B.S. and Starr, M.S. (1992) Motor responses to dopamine Dl and D2 agonists in the reserpinetreated mouse are affected differentially by the NMDA receptor antagonist MK-801.Journal of Neural Transmission,4, 15–26.
Gossel, M., Schmidt, W.J., Löscher, W., Zajaczkowski, W. and Danysz, W. (1995) Effect of co-administration of gluta- mate receptor antagonists and dopaminergic agonists on locomotion in monoamine-depleted rats.Journal of Neural Transmission,10, 27–39.
Greenamyre, J.T., Eller, R.V., Zhang, Z., Ovadia, A., Kurlan, R. and Gash, D.M. (1994) Antiparkinsonian effects of remace- mide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson’s disease.Annals of Neurology,35, 655–661.
Gupta, M., Thomas, R., Bruemmer, V, Feiten, D.L., Gupta, B.K. and Sladek, J.R. (1986) Aged mice are more sensitive to l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine treatment than young adults.Neuroscience Letters,70, 326–331.
Hadfield, M.G. (1972) Uptake and binding of catecholamines. Effect of diphenylhydantoin and a new mechanism of action.Archives of Neurology,26, 78–83.
Hallman, H., Olson, L. and Jonsson, G. (1984) Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-l,2,3,6-tetra- hydropyridine on brain catecholamine neurons in the mouse.European Journal of Pharmacology,97, 133–136.
Hallman, H., Lange, J., Olson, L., Strömberg, I. and Jonsson, G. (1985) Neurochemical and histochemical characterisation of neurotoxic effects of l-methyl-4-phenyl-l,2,3,6-tetra- hydropyridine (MPTP) on brain catecholamine neurons in the mouse.Journal of Neurochemistry,44, 117–127.
Harsing, J.L.G., Magyar, K., Tekes, K., Vizi, E.S. and Knoll, J. (1979) Inhibition by (—)deprenyl of dopamine uptake in the rat striatum: possible correlation between dopamine uptake and acetylcholine release inhibition.Polish Journal of Pharmacological Pharmacolgy,31, 297–307.
Heikkila, R.E., Hess, A. and Duvoisin, R.C. (1984) Dopaminergic neurotoxicity of l-methyl-4-phenyl-l,2,3,6-tetrahydro- pyridine on neostriatal dopamine in mice.Science,224, 1451–1453.
Heikkila, R.E., Sieber, B.-A., Manzino, L. and Sonsalla, P.K. (1989) Some features of the nigrostriatal dopaminergic neurotoxin l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) in the mouse.Molecular and Chemical Neuropathology,10, 171–183.
Heinonen, E.H. and Lammintausta, R. (1991) A review of the pharmacology of selegiline.Acta Neurologica Scandinavica,Suppl 136, 44–59.
Henry, B., Crossman, A.R.et al. (1998) Characterization of enhanced behavioural responses to L-DOPA following repeated administration in the 6-hydroxydopamine- lesioned rat model of Parkinson’s disease.Experimental Neurology,151, 334–342.
Jones-Humble, S.A., Morgan, P.F. and Cooper, B.R. (1993) The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 Black mice in the MPTP animal model of Parkinson’s disease.Life Sciences,54, 245–252.
Jonsson, G., Nwanze, E., Luthman, J. and Sundström, E. (1986) Effect of MPTP and its pyridinium metabolites on mono- amine uptake and on central catecholamine neurons in mice.Ada Physiologica Scandinavica,128, 187–194.
Kalyanaraman, B. Joseph, J.A. and Parthasarathy, S. (1993) The use of spin traps to investigate site-specific formation of free radicals in low-density lipoprotein oxidation.Biochemical Society Transactions,21, 55–74.
Kannari, K. and Markstein, R. (1991) Dopamine antagonists potentiate the antiakinetic effects of competitive NMDA-antagonists in monoamine-depleted mice.Journal of Neural Transmission (Gen. Sect.),84, 211–220.
Kaur, S. and Starr, M. (1996) Motor effects of lamotrigine in naive and dopamine-depleted mice.European Journal of Pharmacology,304, 1–6.
Kirk, R.E. (1995) Experimental design. Procedures in behavioural science. Belmont CA, Brooks/Cole Inc.
Klockgether, T. and Turski, L. (1990) NMDA antagonists potentiate antiparkinsonian actions of L-Dopa in monoamine-depleted rats.Annals of Neurology,30, 717–723.
Knoll, J. (1978) The possible mechanisms of action of (—) deprenyl in Parkinson’s disease.Journal of Neural Transmission,43, 177–198.
Knoll, J. (1987) (-)-Deprenyl (selegiline, Movergan®) facili- tates the activity of the nigrostriatal neuron.Journal of Neural Transmission,25(Suppl.), 45–66.
Knoll, J. (1989) The pharmacology of selegiline [(—) deprenyl].New Aspects. In: Rinne, U.K., Pakkenberg, H., Jensen, N.O. (eds)Ada Neurologica Scandinavica,80 (suppl. 126), pp. 83–91.
Kornhuber, J., Schoppmeyer, K. and Riederer, P. (1993) Affinity of 1-aminoadamantanes for the sigma binding site in post-mortem human frontal cortex.Neuroscience Letters,163, 129–131.
Kornhuber, J., Weiler, M., Schoppmeyer, K. and Riederer, P. (1994) AmantadineandmemantineareNMDAreceptoranfa- gonists.Journal of Neural Transmission,43(Suppl.), 91–104.
Kretschmer, B.D. (1994) Felbamate, an anti-convulsive drug, has anti-parkinsonian potential in rats.Neuroscience Letters,179, 115–118.
Lamb, R.J., Leach, M.J., Miller, A.A. and Wheatley, PL. (1985) Anticonvulsant profile in mice of lamotrigine, a novel anticonvulsant.British Journal of Pharmacology, 85, 366p.
Lange, K.W., Kornhuber, J. and Riederer, P. (1997) Dopamine/ glutamate interactions in Parkinson’s disease.Neuroscience and Biobehavioral Reviews,21, 393–400.
Langston, J.W. (1985) MPTP neurotoxicity: an overview and characterisation of phases of toxicity.Life Sciences,36, 201–206.
Langston, J.W., Ballard, P., Tetrud, J.W. and Irwin, I. (1983) Chronic parkinsonism in humans due to a product of meperidine-analogue synthesis.Science,219, 979–980.
Langston, J.W., Langston, E.B. and Irwin, I. (1984) MPTP- induced parkinsonism in human and nonhuman primates — Clinical and experimental aspects.Acta Neurologica Scandinavica,70(Suppl. 100), 49–54.
Lees, A.J., Shaw, K.M., Kohout, L.J., Stern, G.M., Elsworth, J.D., Sandler, M. and Youdim, M.B.H. (1977) Deprenyl in Parkin- son’s disease.Lancet,2, 791–796.
Lieberman, A. (1992) Long-term experience with selegiline and levodopa in Parkinson’s disease.Neurology,42[Suppl. 4], 32–36.
Lieberman, A. and Fazzini, E. (1991) Experience with selegiline and levodopa in advanced Parkinson’s disease.Acta Neurologica Scandinavica, Suppl. 136, 66–69.
Linden, I.-B., Etemadzedah, E., Schultz, E. and Pohto, P. (1990) Selective catachol-O-methyltransferase inhibition as potential adjunctive treatment with L-dopa in Parkinson’s disease.Movement Disorders,5, 49.
Löscher, W. (1985) Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behaviour in the mongolian gerbil.Journal of Pharmacological and Experimental Therapeutics,233, 204–213.
Löscher, W. and Honack, D. (1995) Anticonvulsant and antieleptogenic effect of L-Deprenyl (Selegiline) in the kindling model of epilepsy.Journal of Pharmacological and Experimental Therapeutics,274, 307–314.
Löscher, W. and Lehmann, H. (1996) 1-Deprenyl (Selegiline) exerts anticonvulsant effects against different seizure types in mice.Journal of Pharmacological and Experimental Therapeutics,277, 1410–1417.
Maj, J., Skuza, G. and Rogoz, Z. (1993a) Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity.Journal of Neural Transmission (PD&D Sect.),6, 53–62.
Maj, R., Antongiovanni, V, Bonsignori, A., Breda, M., Dostert, P., Fariello, R.G., McArthur, R.A., Varasi, M. and Bianchetti, A. (1993b) Anticonvulsant profile of benzyl-aminopropranamide derivatives in mice and rats. Abstract presented at theFocus on Epilepsy II, International Conference, Whistler, Canada.
Melamed, E., Martinovits, G., Pikarsky, E., Rosenthal, J. and Uzzan, A. (1986) Diphenylhydantoin and phenobarbital suppresses the dopaminergic neurotoxicity of MPTP in mice.European Journal of Pharmacology,128, 255–257.
Meldrum, B.S. (1994) The role of glutamate in epilepsy and other CNS disorders.Neurology,44, S14-S23.
Merritt, H.H. and Putnam, T.J. (1938) A new series of anticonvulsant drugs tested by experiments in animals.Archives of Neurology and Psychiatry,39, 1003–1015.
Miller, A.A., Wheatley, P., Sawyer, D.A., Baxter, M.G. and Roth, B. (1986) Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: 1. Anticonvulsant profile in mice and rats.Epilepsia,27, 483–489.
Morelli, M., Fenu, S., Pinna, A. and DiChiara, G. (1992) Opposite effects of NMDA receptor blockade on dopaminergic Dl-mediated and D2-mediated behaviour in the 6-hydroxydopamine model of turning — relationship with c-fos expression.Journal of Pharmacological and Experimental Therapeutics,260, 402–408.
Mytilineou, C. and Cohen, G. (1985) Deprenyl protects dopamine neurons from the neurotoxic effects of 1-methyl-4-phenylpyridium ion.Journal of Neurochemistry,45, 1951–1953.
Nickel, B., Schulze, G. and Szelenyi, I. (1990) Effect of enantiomers of deprenyl (selegiline) and amphetamine on physical abuse liability and cortical electrical activity in rats.Neuropharmacology,29, 983–992.
O’Brien, E.M., Tipton, K.F., Meroni, M. and Dostert, P. (1994) Inhibition of monoamine oxidase by clorgyline analogues.Journal of Neural Transmission,41[Suppl.], 295–305.
Olanow, C.W. and Calne, D.B. (1991) Does selegiline mono- therapy in Parkinson’s disease act by symtomatic or protective mechanisms?Neurology,42[Suppl], 13–26.
Olson, W.L., Gruenthal, M., Mueller, M.E. and Olson, W.H. (1997) Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial.American Journal of Medicine,102, 60–66.
Ovadia, A., Zhang, Z. and Gash, D.M. (1995) Increased susceptability to MPTP toxicity in middle-aged rhesus monkeys.Neurobiology of Aging,16, 931–937.
Palmer, G.C., Cregan, E.F., Borrelli, A.R. and Willett, F. (1995) Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride.Annals of the New York Academy of Sciences,765, 236–247.
Papa, S.M., Boldry, R.C., Engber, T.M., Kask, A.M. and Chase, T.N. (1995) Reversal of Levodopa-induced motor fluctuations in experimental parkinsonism by NMDA receptor blockade.Brain Research,701, 13–18.
Parkinson Study Group. (1993) Effects of tocopherol and deprenyl on the progression of disability in early Parkin- son’s disease.New England Journal of Medicine,328, 176–183.
Parsons, CG., Gruner, R., Rozental, J., Millar, J. and Lodge, D. (1993) Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (l-amino-3,5-dimethyladamantane).Neuropharmacology,32, 1337–1350.
Parsons, CG., Krishtal, O.A. and Misgeld, U. (1994) Comparative studies on NMDA receptor antagonism by aman- tadine (1-aminoadamantane) and memantine (l-amino-3,5- dimethyladamantane).Society for Neuroscience Abstracts,20, 470–477.
Paterson, I.A., Juorio, A.V. and Boulton, A.A. (1990) Possible mechanism of action of deprenyl in Parkinsonism.Lancet,36, 193.
Philips, S.R. and Boulton, A.A. (1979) The effect of monoamine oxidase inhibitors on some arylalkylamines in rat striatum.Journal of Neurochemistiy,33, 159–167.
Phillis, J.W. and Clough-Helfman, C. (1990) Protection from cerebral ischemic injury in gerbils with spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN).Neuroscience Let- ters,116, 315–319.
Prockop, DJ., Shore, P.A. and Brodie, B.B. (1959) An anti- convulsant effect of monoamine oxidase inhibitors.Experientia,15, 145–147.
Rabey, J.M., Nissipeanu, P. and Korczyn, A.D. (1992) Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson’s disease.Journal of Neural Transmission (PD&D Sect.),4, 277–282.
Ramsay, R.E., Wilder, B.J., Berger, J.R. and Bruni, J. (1983) A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults.Neurology,33, 904–910.
Reynolds, G.P., Elsworth, J.D., Blau, K., Sandier, M., Lees, A.J. and Stern, G.M. (1978) Deprenyl is metabolized to metham- phetamine and amphetamine in man.British Journal of Clinical Parmacology,6, 543–544.
Rho, J.M., Donevan, S.D. and Rogawski, M.A. (1994) Mechanism of action of anticonvulsant felbamate: opposing effects on N-methyl-D-aspartate and 7-aminobutyric acid A receptors.Annals of Neurology,35, 229–234.
Ricaurte, G.A., Irwin, I., Forno, L.S., DeLanney, L.E., Langston, E. and Langston, J.W. (1987) Aging and l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra.Brain Research,403, 43–51.
Riekkinin, M., Kejonen, K.et al. (1998) Reduction of noradre- naline impairs attention and dopamine depletion slows responses in Parkinson’s disease.European Journal of Neuroscience,10, 1429–1435.
Rinne, U.K. (1989) Combination of a dopamine agonist, MAO- B inhibitor and levodopa — a new strategy in the treatment of early Parkinson’s disease.Acta Neurologica Scandinavica,126[Suppl.], 165–169.
Rouillard, C, Bédard, P., Falardeau, P. and DiPaolo, T. (1987) Behavioural and biochemical evidence for a different effect of repeated administration of L-Dopa and bromocriptine on denervated versus non-denervated striatal dopamine receptors.Neuropharmacology,26, 87–91.
Schmidt, W.J. (1994) Behavioural effects of NMDA- receptor antagonists.Journal of Neural Transmission, Suppl.43, 63–69.
Schmidt, W.J. and Kretschmer, B.D. (1997) Behavioural phar- macology of glutamate receptors in the basal ganglia.Neuroscience and Biobehavioral Reviews,21, 381–392.
Schulz, J.B., Henshaw, D.R., Matthews, R.T. and Beal, EM. (1995) Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity.Experimental Neurology,132, 279–283.
Sen, S. and Phillis, J.W. (1993) Alpha-phenyl-tert-butyl- nitrone (PBN) attenuates hydroxyl radical production during ischemia-reperfusion injury of rat brain: an EPR study.Free radicals Research. Communications,19, 255–265.
Serchen, H., Mason, M.F., Hashim, A. and Lajtha, A. (1985) Effect of N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) on age related changes in dopamine turnover and transport function in the mouse striatum.European Journal of Pharmacology,113, 136–146.
Silverman, P.B. (1992) Sensitization, response fluctuation and long-term effect of SKF-82958 and bromocriptine in the hemi-parkinsonian rat.European Journal of Pharmacology,229, 235–240.
Shinotoh, H., Vingerhoets, F.J., Lee, C.S., Uitti, R.J., Schulzer, M., Calne, D.B. and Tsui, J. (1997) Lamotrigine trial in idiopathic parkinsonism: a double-blind, placebo- controlled, crossover study.Neurology,48, 1282–1285.
Shoulson, Y. and Chase, T.N. (1976) Clonidine and the anti- parkinsonian response to L-Dopa or piribedil.Neuropharmacology,15, 25–27.
Skuza, G., Rogoz, R., Quack, G. and Danysz, W. (1994) Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats.Journal of Neural Transmission (Gen. Sect.),98, 57–67.
Sonsalla, P.K. and Heikkila, R.E. (1986) The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice.European Journal of Pharmacology,129, 339–345.
Socci, D.J., Crandall, B.M. and Arendash, G.W (1995) Chronic antioxidant treatment improves the cognitive performance of aged rats.Brain Research,693, 88–94.
Starr, M.S. and Starr, B.S. (1994) Potentiation of dopamine- dependent locomotion by clonidine in reserpine-treated mice is restricted to D2 agonists.Journal of Neural Transmis- sion: Parkinson’s Disease and Dementia Section,7, 133–142.
Strolin Benedetti, M., Marrari, P., Colombo, M., Castelli, M.G., Arand, M., Oesch, F. and Dostert, P. (1994) The anticonvulsant’ FCE 26743 is a selective and short-acting MAO-B inhibitor devoid of inducing properties towards cytochrome P450-dependent testosterone hydroxylation in mice and rats.Journal of Pharmacological Pharmacology,46, 814–819.
Sundström, E., Goldstein, M. and Jonsson, G. (1986) Uptake inhibition protects nigrostriatal dopamine neurons from the neurotoxicity of l-methyl-4-phenyl-l,2,3,6-tetrahydro- pyridine (MPP+) in mice.European Journal of Pharmacology,131, 289–292.
Sundström, E., Strömberg, I., Tsutsumi, T., Olson, L. and Jonsson, G. (1987) Studies on the effects of l-methyl-4- phenyl-l,2,3,6-tetrahydropyridine (MPTP) on central cate- cholamine neurons in C57 BL/6 mice. Comparison with three other strains of mice.Brain Research,405, 26–38.
Sundström, E., Fredriksson, A. and Archer, T. (1990) Chronic neurochemical and behavioural changes in MPTP-lesioned C57 BL/6 mice: a model for Parkinson’s disease.Brain Research,528, 181–188.
Svensson, A., Carlsson, M. and Carlsson, A. (1991) Synergistic interactions between the NMDA antagonist dizocilpine and the preferential dopamine autoreceptor antagonists (+)- AJ 76 and (+)-UH 232 with regard to motor stimulation in monoamine-depleted mice.Journal of Neural Transmission (Gen. Sect),85, 117–129.
Tarsy, D., Parkes, J.D.et al. (1975) Clonidine in Parkinson’s disease.Archives of Neurology,32, 134–136.
Thiffault, C, Quiron, R., Aumont, N. and Poirier, J. (1992) The effect of L-deprenyl and MPTP on Superoxide dismutase activity in the striatum of C57BL/6 mice.Society for Neuroscience Abstracts,18, 1443.
Tipton, K.F. and Singer, T.P. (1993) Advances in our understanding of the mechanisms of the toxicity of MPTP and related compounds.Journal of Neurochemistry,61, 1191–1206.
Tolliver, T.I., Huang, S.J., Chiueh, C.C., Murphy, D.L. and Tolliver, J.M. (1993) A comparison of deprenyl (selegiline) and MPP+ on cocaine-sensitive dopamine uptake sites.Society for Neuroscience Abstracts,19, 402.
Verhagen-Metman, L., Blanchet, P.J., Mouradian, M.M. and Chase, T.N. (1996) Dextromethorphan and levodopa combination therapy in parkinsonian patients with response fluctuations.Movement Disorders,11[Suppl. 1], 184.
Vezina, P., Mohr, E. and Grimes, D. (1992) Deprenyl in Parkinson’s disease: mechanisms, neuroprotective effect, indications and adverse effects.Canadian Journal of Neurological Science,19 [1 Suppl], 142–146.
Wachtel, S.R. and Abercrombie, E.D. (1994) L-3,4-dihydroxy- phenylalanine-induced dopamine release in the striatum of intact and 6-hydroxydopamine-treated rats: differential effects of monoamine oxidase A and B inhibitors.Journal of Neurochemistry,63, 108–117.
Wallace, S.J. (1994) Lamotrigine — a clinical overview.Seizure,3, 47–51.
Walsh, S.L. and Wagner, G.C. (1989) Age-dependent effects of l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP); correlation with monoamine oxidase-B.Synapse,3, 308–314.
Weihmüller, F.B., Hadjiconstantinou, M. and Bruno, J.P. (1989) Dissociation between the biochemical and behavioural recovery in MPTP-treated mice.Pharmacology, Biochemistry and Behavior,34, 113–117.
Wessel, K. and Szelenyi, I. (1992) Selegiline — an overview of its role in the treatment of Parkinson’s disease.Clinical Investigations,70, 459–462.
Wheatley, P. and Miller, A.A. (1989) Effects of lamotrigine on electrically induced after discharge in aneasthetised rat, dog and marmoset.Epilepsia,30, 34–40.
Wong, E.H.F., Kemp, J.A., Priestly, T., Knight, A.R., Woodruff, G.N. and Iversen, L.L. (1986) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.Proceedings of the National Academy of Sciences, USA,83, 7104–7108.
Wu, R.-M., Chiueh, C.C., Pert, A. and Murphy, D.L. (1993) Apparent antioxidant effect of l-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo.European Journal of Pharmacology,243, 241–247.
Wu, R.-M., Murphy, D.L. and Chiueh, C.C. (1994) Protection of nigral neurons against MPP+-induced oxidative injury by deprenyl (selegiline), U-78517F, and DMSO.New Trends in Clinical Neuropharmacology,8, 187–188.
Yahr, M.D. (1996) Editorial.Parkinsonism and Related Disorders,2, 123–124.
Yahr, M.D., Mendoza, M.R., Moros, D. and Bergmann, K.J. (1983) Treatment of Parkinson’s disease in early and late phases. Use of pharmacological agents with special reference to derenyl (selegiline).Acta Neurologica Scandinavica, Suppl95, 95–102.
Ye Liu, Y, Yu, H., Mohell, N., Nordvall, G., Lewander, T. and Hackseil, U. (1995) Derivatives of cis-2-amino-8-hydroxy- 1-methyltetralin; mixed 5-HTlA-receptor agonists and dopamine-D2-receptor antagonists.Journal of Medical Chemistry,38, 150–160.
Yoshida, T., Oguro, T. and Kuroiwa, Y. (1987) Hepatic and extrahepatic metabolism of deprenyl, a selective mono-amine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences.Xenobiotica,17, 957–963.
Yoshida, T., Yamada, Y., Yamamoto, T. and Kuroiwa, Y. (1986) Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency.Xenobiotica,16, 129–136.
Youdim, M.B.H. (1978) The active centers of monoamine oxidase types ’A’ and ’B’; binding with (14C)-clorgyline and (14C)-deprenyl.Journal of Neural Transmission,43, 199–208.
Youdim, M.B.H. and Finberg, J.P. (1994) Pharmacological actions of L-Deprenyl (selegiline) and other selective monoamine oxidase B inhibitors.Clinical Pharmacology and Therapy,56, 725–733.
Zipp, F., Baas, H. and Fischer, P.A. (1993) Lamotrigine — antiparkinsonian activity by blockade of glutamate release?Journal of Neural Transmission (P-D Sect.),5, 67–75.
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Archer, T., Fredriksson, A. Restoration and putative protection in parkinsonism. neurotox res 2, 251–292 (2000). https://doi.org/10.1007/BF03033798
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DOI: https://doi.org/10.1007/BF03033798