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Gene-environment interplay in affect and dementia: Emotional modulation of cognitive expression in personal outcomes

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Abstract

A multitude of factors, that either singly, interactively, or sequentially influence the gene-environment interplay in affective and dementia states, include several phases of neurodevelopmental liability in both humans and laboratory animals. Genetic vulnerability for both affective disorders and dementia describes a scenario distinguished by progressive need for concern, particularly in view of the interplay between these areas of ill-health. The contribution of emotional and cognitive expression to personal outcomes, e.g., as a function of affective personality type, a state-dependent analysis of personality characteristics, appears to pervade both the individual’s experience of social and physical environments and the performance of cognitive tasks. The role of the endocannabinoids in mental health may offer insights for the psychopharmacology of both cognition and affect. Maladaptive emotional reactions and a defective cognitive ability will contribution to unsatisfactory/maladaptive coping strategies, in turn, leading to further complications of an affective and dysfunctional nature, eventually with a clinical psychopathological outcome. These considerations impinge upon critical issues concerning predisposition and vulnerability. Classical eye-blink conditioning provides a highly established procedure for assessment of defective physiology in models of Alzheimer’s dementia. In order to develop a consideration of the array of situations presenting the variation of outcome due to type of affective personality, the role of fear and anxiety and stress in affective states influencing cognition are examined and the critical role of brain circuits mediating emotions influencing cognitive outcomes is discussed.

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References

  • Aarsland D, Tandberg E, Larsen JP, Cummings JL (1996) Frequency of dementia in Parkinson disease. Arch. Neurol. 53, 538–542.

    PubMed  CAS  Google Scholar 

  • Adolphs R, D Tranel and H Damasio (2001) Emotion recognition from faces and prosody following temporal lobecto-my.Neuropsychology 15, 396–404.

    Article  PubMed  CAS  Google Scholar 

  • Akiskal HS, RM Hirschfeld and BI Yerevanian (1983) The relationship of personality to affective disorders.Arch. Gen. Psychiatr. 40, 801–810.

    PubMed  CAS  Google Scholar 

  • Aldwin CM (1994)Stress, Coping and Development: an Integrative Perspective (Guilford: New York).

    Google Scholar 

  • Almagor M and Y Ben-Porath (1989) The two-factor model of self-reported mood: a cross-cultural replication.J. Personality Assess. 53, 10–21.

    Article  CAS  Google Scholar 

  • Archer T (1982) Serotonin and fear retention in the rat.J. Comp. Physiol. Psychol. 96, 476–490.

    Article  PubMed  CAS  Google Scholar 

  • Bahar A, S Anat and Y Dudai (2003) The amygdala circuit that acquires taste aversion memory differs from the circuit that extinguishes it.Eur. J. Neurosci. 17, 1527–1530.

    Article  PubMed  Google Scholar 

  • Barria A, D Muller, V Derkach and T Soderling (1997) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.Science 276, 2042–2045.

    Article  PubMed  CAS  Google Scholar 

  • Barros DM, T Mello e Souza, T De David, T Choi, A Aguzzoli, C Madche, P Ardenghi, JH Medina and I Izquierdo (2001) Simultaneous modulation of retrieval by dopaminergic D1, ß-noradrenergic, serotonergic1A, and cholinergic muscarinic receptors in cortical structures of the rat.Behav. Brain Res. 124, 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Bauer EP, GE Schafe and JE LeDoux (2002) NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala.J. Neurosci. 22, 5239–5249.

    PubMed  CAS  Google Scholar 

  • Bechara A (2004) The role of emotion in decision-making: evidence from neurological patients with orbitofrontal damage.Brain and Cogn. (in press)

  • Bechara A, H Damasio and AR Damasio (2000) Emotion, decision-making, and the orbitofrontal cortex.Cerebral Cortex 10, 295–307.

    Article  PubMed  CAS  Google Scholar 

  • Beckett WS (2002) Post-traumatic stress disorder.New Engl. J. Med. 346, 1495–1498.

    Article  PubMed  Google Scholar 

  • Bergquist J and R Ekman (2001) Future aspects of psychoneuroim-munology — lymphocyte peptides reflecting psychiatric studied by mass spectrometry.Arch. Phys. Biochem. 109, 369–371.

    CAS  Google Scholar 

  • Berman DE and Y Dudai (2001) Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex.Science,291, 417–419.

    Article  Google Scholar 

  • Berrettini W (1998) Progress and pitfalls: bipolar molecular linkage studies.J. Affect. Disord. 50, 287–297.

    Article  PubMed  CAS  Google Scholar 

  • Blair HT, GE Schafe, EP Bauer, SM Rodrigues and JE LeDoux (2001) Synaptic plasticity in the lateral amygdale: a cellular hypothesis of fear conditioning.Learn. Mem. 8, 229–242.

    Article  PubMed  CAS  Google Scholar 

  • Blanchard R, JM Fellous, FS Guimaraes, W Irwin, JE LeDoux, JL McGaugh, JB Rosen, LC Schenberg, E Volchan and C Da Cunha (2001) The brain decade in debate: III. Neurobiology of emotion.Braz. J. Med. Biol. Res. 34, 283–293.

    Article  PubMed  CAS  Google Scholar 

  • Bless H (2000) The interplay of affect and cognition: the mediating role of general knowledge structures, In:Feeling and Thinking: The Role of Affect in Social Cognition (Forgas JP, Ed.) (Cambridge University Press: Cambridge, UK), pp 201–222.

    Google Scholar 

  • Bood SÅ, T Archer and T Norlander (2004) Affective personality in relation to general personality, self-reported stress, coping, and optimism.Individual Differences Research (in press)

  • Bovasso GB (2001) Cannabis abuse as a risk factor for depressive symptoms.Am. J. Psychiatry 158, 2033–2037.

    Article  PubMed  CAS  Google Scholar 

  • Boyce P, G Parker, B Barnett, M Cooney and F Smith (1991) Personality as a vulnerability factor to depression.Br. J. Psychiatr. 159, 106–114.

    Article  CAS  Google Scholar 

  • Breitenstein C, D Van Lancker, I Daum and C Waters (2001) Impaired perception of vocal emotions in Parkinson’s disease: influence of speech time processing and executive functioning.Brain Cogn. 45, 277–314.

    Article  PubMed  CAS  Google Scholar 

  • Brun V, K Ytterbo, R Morris, M Moser and E Moser (2001) Retrograde amnesia for spatial memory induced by NMDA receptor-mediated long-term potentiation.J. Neurosci. 21, 356–362.

    PubMed  CAS  Google Scholar 

  • Bucks RS and SA Radford (2004) Emotion processing in Alzheimer’s disease.Aging Ment. Health 8, 222–232.

    Article  PubMed  CAS  Google Scholar 

  • Bush G, JA Frazier, SL Rauch, LJ Seidman, PJ Whalen, MA Jenike, BR Rosen and J Biederman (1999) Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop.Biol. Psychiatry 45, 1542–1552.

    Article  PubMed  CAS  Google Scholar 

  • Cahill L and JL McGaugh (1996) Mechanisms of emotional arousal and lasting declarative memory.TINS 21, 294–299.

    Google Scholar 

  • Cahill L, JL McGaugh and B Roozendaal (1996) Involvement of the amygdala in memory: interaction with other brain systems.Proc. Natl. Acad. Sci. USA 93, 13508–13514.

    Article  PubMed  Google Scholar 

  • Camerer C, G Loewenstein and D Prelec (2004) Neuroeconomics: how neuroscience can inform economics. Unpublished manuscript.

  • Cameron HA, TG Hazel and RDG McKay (1998) Regulation of neurogenesis by growth factors and neurotransmitters.J. Neurobiol. 36, 287–306.

    Article  PubMed  CAS  Google Scholar 

  • Cammarota M, ML de Stein, G Paratcha, LR Bevilaqua, I Izquierdo and JH Medina (2000) Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus.Neurochem. Res. 25, 567–572.

    Article  PubMed  CAS  Google Scholar 

  • Cammarota M, LR Bevilaqua, D Kerr, JH Medina and I Izquierdo (2003) Inhibition of mRNA and protein synthesis in the CA1 region of the dorsal hippocampus blocks reinstallment of an extinguished conditioned fear response.J. Neurosci. 23, 737–741.

    PubMed  CAS  Google Scholar 

  • Cammarota M, LR Bevilaqua, JS Bonini, JI Rossatto, JH Medina and I Izquierdo (2004) Hippocampal glutamate receptors in fear memory consolidation.Neurotoxicity Res. 6, 205–212.

    Google Scholar 

  • Chen G, KS Chen, J Knox, J Inglis, A Bernard, SJ Martin, A Justice, L McConlogue, D Games, SB Freeman and RGM Morris (2000) A learning deficit related to age and ß-amyloid plaques in a mouse model of Alzheimer’s disease.Nature 408, 975–979.

    Article  PubMed  CAS  Google Scholar 

  • Chen A, G Muzzio, G Malleret, D Bartsch, M Verbitsky, P Pavlidis, AL Yonan, S Vronskaya, MB Grody, I Cepeda, TC Gilliam and ER Kandel (2003) Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins.Neuron 39, 655–669.

    Article  PubMed  CAS  Google Scholar 

  • Cirulli F (2001) Role of environmental factors on brain development and nerve growth factor expression.Physiol. Behav. 73, 321–330.

    Article  PubMed  CAS  Google Scholar 

  • Clore GL, K Gasper and E Gervin (2001) Affect-as-information, In:Handbook of Affect and Social Cognition (Forgas JP, Ed.) (Erlbaum: Mahwah, NJ), pp 121–144.

    Google Scholar 

  • Damasio AR, TJ Grabowski, A Bechara, H Damasio, LLB Ponto, J Parvizi and RD Hichwa (2000) Subcortical and cortical brain activity during the feeling of self-generated emotions.Nature Neurosci. 3, 1049–1056.

    Article  PubMed  CAS  Google Scholar 

  • Davis M (2002) Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy.Eur. J. Neurosci. 16, 395–398.

    Article  PubMed  Google Scholar 

  • Debiec J, JE LeDoux and K Nader (2002) Cellular and systems reconsolidation in the hippocampus.Neuron 36, 527–538.

    Article  PubMed  CAS  Google Scholar 

  • Degenhardt L, W Hall and MT Lynskey (2001) Alcohol, cannabis and tobacco use among Australians: a comparison of their associations with other drug use and use disorders, affective and anxiety disorders, and psychosis.Addiction 96, 1603–1614.

    Article  PubMed  CAS  Google Scholar 

  • Delgado-Garcia JM and A Gruart (2002) The role of interpositus nucleus in eyelid conditioned responses.The Cerebellum 1, 289–308.

    Article  PubMed  CAS  Google Scholar 

  • De Wied D and HO Sigling (2002) Neuropeptides involved in the pathophysiology of schizophrenia and major depression.Neurotoxicity Res. 4, 453–468.

    Article  CAS  Google Scholar 

  • Donaldson C, N Tarrier and A Burns (1998) Determinants of carer stress in Alzheimer’s disease.Int. J. Geriatr. Psychiatr. 13, 248–256.

    Article  CAS  Google Scholar 

  • Egeland JA, DS Gerhard, DL Pauls, JN Sussex, KK Kidd, CR Allen, AM Hostetter and DE Housman (1987) Bipolar affective disorders linked to DNA markers on chromosome 11.Nature 325, 783–787.

    Article  PubMed  CAS  Google Scholar 

  • Eysenck HJ and SBG Eysenck (1975)Manual of the Eysenck Personality Questionnaire (Educational and Industrial Testing Service: San Diego, CA).

    Google Scholar 

  • Falls WA, MJ Miserendino and M Davis (1992) Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala.J. Neurosci. 12, 854–863.

    PubMed  CAS  Google Scholar 

  • Fanous AH and KS Kendler (2004) The genetic relationship of personality to major depression and schizophrenia.Neurotoxicity Res. 6, 43–50.

    Google Scholar 

  • Fanous AH, CO Gardner, CA Prescott, R Cancro and KS Kendler (2002) Neuroticism, major depression and gender: a population-based twin study.Psychol. Med. 32, 719–728.

    Article  PubMed  CAS  Google Scholar 

  • Farmer A, K Redman, T Harris, A Mahmood, S Sadler, A Pickering and P McGuffin (2002) Neuroticism, extraversion, life events and depression: the Cardiff Depression Study.Br. J. Psychiatr. 181, 118–122.

    Google Scholar 

  • Fiedler K (2000) Toward an integrative account of affect and cognition phenomena using BIAS computer algorithm, In:Feeling and Thinking: The Role of Affect in Social Cognition (Forgas J P, Ed.) (Cambridge University Press: Cambridge, UK), pp 223–241.

    Google Scholar 

  • Fergusson DM and LJ Horwood (2000) Does cannabis use encourage other forms of illicit drug use?Addiction 95, 505–520.

    Article  PubMed  CAS  Google Scholar 

  • Floresco SB, JK Seamans and AG Phillips (1997) Selective roles for hippocampus, prefrontal cortex, and ventral striatal circuits in radial arm maze tasks with or without a delay.J. Neurosci. 17, 1880–1890.

    PubMed  CAS  Google Scholar 

  • Folkesson P, C Nyberg, T Archer and T Norlander (2002) Soccer referees’ experience of threat and aggression: effects of age, experience and life orientation on outcome of coping strategy.Aggressive Behaviour 28, 317–327.

    Article  Google Scholar 

  • Forgas JP (1995) Mood and judgement: the affect infusion model.Psychol. Bull. 117, 39–66.

    Article  PubMed  CAS  Google Scholar 

  • Garcia R (2001) Stress, hippocampal plasticity and spatial learning.Synapse 40, 180–183.

    Article  PubMed  CAS  Google Scholar 

  • Garner C, LA McInnes, SK Service, M Spesny, E Fournier, P Leon and NB Freimer (2001) Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method.Am. J. Human Genet. 68, 1061–1064.

    Article  CAS  Google Scholar 

  • Gasper K (2004) Do you see what I see? Affect and visual information processing.Cogn. Emotion 18, 405–421.

    Article  Google Scholar 

  • Gershon ES, WE Bunney Jr, J Leckman, M Van Eerdewegh and B DeBauche (1976) The inheritance of affective disorders: a review of data and hypothesis.Behav. Genet. 6, 227–261.

    Article  PubMed  CAS  Google Scholar 

  • Goldapple K, Z Segal, C Garson, M Lau, P Bieling, S Kennedy and H Mayberg (2004) Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behaviour therapy.Arch. Gen. Psychiatr. 61, 34–41.

    Article  PubMed  Google Scholar 

  • Greenberg BD, Q Li, FR Lucas, S Hu, LA Sirota, J Benjamin, KP Lesch, D Hamer and DL Murphy (2000) Association between the serotonin transporter promotor polymorphism and personality traits in a primarily female population sample.Am. J. Med. Genet. 96, 202–216.

    Article  PubMed  CAS  Google Scholar 

  • Grispoon L and JB Bakalar (1997) Marihuana, In:Substance Abuse. A Comprehensive Textbook (Lovinson JH, RB Millman and JG Langrod, Eds.) (Williams and Wilkins: Baltimore, MD), pp 199–206.

    Google Scholar 

  • Gruart A, P Blazquez and JM Delgado-Garcia (1995) Kinematics of unconditioned and conditioned eyelid movements in the alert cat.J. Neurophysiol. 74, 226–248.

    PubMed  CAS  Google Scholar 

  • Gruart A, BG Screurs, E Dominguez del Toro and JM Delgado-Garcia (2000) Kinetic and frequency-domain properties of reflex and conditioned eyelid responses in the rabbit.J. Neurophysiol. 83, 836–852.

    PubMed  CAS  Google Scholar 

  • Hall W (2001) Reducing the harms caused by cannabis use: the policy debate in Australia.Drug Alcohol Depend. 62, 163–174.

    Article  PubMed  CAS  Google Scholar 

  • Hamann S, ES Monarch and FC Goldstein (2002) Impaired fear conditioning in Alzheimer’s disease.Neuropsychologia 40, 1187–1195.

    Article  PubMed  Google Scholar 

  • Hatfield T and JL McGaugh (1999) Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task.Neurobiol. Learn. Mem. 71, 232–239.

    Article  PubMed  CAS  Google Scholar 

  • Herkenham M, AB Lynn, MR Johnson, LS Melvin, BR de Costa and KC Rice (1991) Characterization and localization of cannabi-noid receptors in rat brain: a quantitativein vitro autoradiograph-ic study.J. Neurosci. 11, 563–583.

    PubMed  CAS  Google Scholar 

  • Herrmann C (1997) International experiences with hospital anxiety and depression scales — a review validating data and clinical results.J. Psychosomat. Res. 11, 213–218.

    Google Scholar 

  • Hirschfeld RM, GL Klerman, PJ Clayton, MB Keller, P McDonald-Scott and BH Larkin (1983) Assessing personality: effects of the depressive state on trait measurement.Am. J. Psychiatr. 140, 695–699.

    PubMed  CAS  Google Scholar 

  • Hockey GRJ, AJ Maule, PJ Clough and J Bdzola (2000) Effects of negative mood states on risk in everyday decision making.Cogn. Emotion 14, 823–855.

    Article  Google Scholar 

  • Huebner ES and T Dew (1995) Preliminary validation of the positive and negative affect schedule with adolescents.J. Psycho-educational Assess.13, 286–293.

    Article  Google Scholar 

  • Igaz LM, P Bekinschtein, MMR Vianna, I Izquierdo and JH Medina (2004) Gene expression during memory expression.Neurotoxicity Res. 6, 189–204.

    Google Scholar 

  • Issa AM, W Rowe, S Gauthier and MJ Meaney (1990) Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and unimpaired rats.J. Neurosci. 10, 3247–3254.

    PubMed  CAS  Google Scholar 

  • Izquierdo I, M Cammarota, MMR Vianna and LRM Bevilaqua (2004) The inhibition of acquired fear.Neurotoxicity Res. 6, 175–188.

    Google Scholar 

  • James IA (2001) Therapeutic implications of the interactive cognitive subsystems (ICS) model for people with dementia.PSIGE Newsletter 77, 32–36.

    Google Scholar 

  • Jardine R, NG Martin and AS Henderson (1984) Genetic covariation between neuroticism and the symptoms of anxiety and depression.Genet. Epidemiol. 1, 89–107.

    Article  PubMed  CAS  Google Scholar 

  • Jay TM, H Gurden, C Rocher, M Hotte and M Spedding (2004a) Up and down regulation of synaptic strength at hippocampal to pre-frontal synapses, In: The Prefrontal Cortex: From Synapse to Cognition (Otani S, Ed.) (Kluwer: Amsterdam), pp 107–130.

    Chapter  Google Scholar 

  • Jay TM, C Rocher, M Hotte, L Naudon, H Gurden and M Spedding (2004b) Plasticity at hippocampal to prefrontal synapses is impaired by loss of dopamine and stress. Evidence for a potential neuroanatomical substrate involved in psychiatric diseases.Neurotoxicity Res. 6, 233–244.

    Google Scholar 

  • Joffe JM (1965) Genotype and prenatal and premating stress interact to affect adult behaviour in rats.Science 150, 1844–1845.

    Article  PubMed  CAS  Google Scholar 

  • Johns A (2001) Psychiatric effects of cannabis. Br. J.Psychiatry 178, 116–122.

    CAS  Google Scholar 

  • Keane J, AJ Calder, JR Hodges and AW Young (2002) Face and emotion processing in frontal variant frontotemporal dementia.Neuropsychologia 40, 655–665.

    Article  PubMed  Google Scholar 

  • Kelsoe JR, EI Ginns, JA Egeland, DS Gerhard, AM Goldstein, SJ Bale, DL Pauls, RT Long, KK Kidd, G Conte, DE Housman and SM Paul (1989) Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.Nature 342, 238–243.

    Article  PubMed  CAS  Google Scholar 

  • Kercher K (1992) Assessing subjective well-being in the old-old: the PANAS as a measure of orthogonal dimensions of positive and negative affect.Research on Aging 14, 131–168.

    Article  Google Scholar 

  • Kerr TA, K Schapira, M Roth and RF Garside (1970) The relationship between the Maudsley Personality Inventory and the course of affective disorders.Br. J. Psychiatr. 116, 11–19.

    Article  CAS  Google Scholar 

  • Kilic C and M Ulusoy (2003) Psychological effects of the November 1999 earthquake in Turkey: an epidemiological study.Acta Psychiatr. Scand. 108, 232–238.

    Article  PubMed  CAS  Google Scholar 

  • Kouri EM, HG Pope and SG Lukas (1999) Changes in aggressive behaviour during withdrawal from long-term marijuana use.Psychopharmacology 143, 302–308.

    Article  PubMed  CAS  Google Scholar 

  • Kurucz J, G Feldmar and W Werner (1979) Prosopo-affective agnosia associated with organic brain damage.J. Am. Geriatr. Soc. 27, 91–95.

    PubMed  CAS  Google Scholar 

  • Lamprecht R, CR Farb and JE LeDoux (2002) Fear memory formation involves p190 and ROCK proteins through a GRB2-mediated complex.Neuron 36, 727–738.

    Article  PubMed  CAS  Google Scholar 

  • Lauer CJ, T Bronisch, M Kainz, W Schreiber, F Holsboer and JC Krieg (1997) Premorbid psychometric profile of subjects at high familial risk for affective disorder.Psychol. Med. 27, 355–362.

    Article  PubMed  CAS  Google Scholar 

  • LeDoux JE (1993) Emotional memory systems in the brain.Behav. Brain Res. 58, 69–79.

    Article  PubMed  CAS  Google Scholar 

  • LeDoux JE (1995) Emotion: clues from the brain.Annu. Rev. Psychol. 46, 209–235.

    Article  PubMed  CAS  Google Scholar 

  • LeDoux JE (1996)The Emotional Brain: The Mysterious Underpinnings of Emotional Life (Simon & Schuster, Inc.: New York).

    Google Scholar 

  • LeDoux JE (2003) The emotional brain, fear, and the amygdale.Cell. Mol. Neurobiol. 23, 727–738.

    Article  PubMed  Google Scholar 

  • LeDoux JE and G Collingridge (2002) Founding editorial: learning and memory.The Scientific World J. 2, 1685–1688.

    Google Scholar 

  • LeDoux JE and JM Gorman (2001) A call to action: overcoming anxiety through active coping.Am. J. Psychiatr. 158, 1953–1955.

    Article  PubMed  CAS  Google Scholar 

  • Le Moal M, DN Abrous, VLemaire and M-F Montaron (2004) Environmental-induced long-term structural changes: cues for functional orientation and vulnerabilities.Neurotoxicity Res. 6 (in press)

  • Leverich GS, SL McElroy, T Suppes, PE Keck, KD Denikoff, WA Nolen, LL Altshuler, AJ Rush, R Kupka, MA Frue, KA Autio and RM Post (2002) Early physical and sexual abuse associated with adverse course of bipolar illness.Biol. Psychiatr. 51, 288–297.

    Article  Google Scholar 

  • Levine S (2002) Regulation of the hypothalamic-pituitary-adrenal axis in the neonatal rat: the role of maternal behaviour.Neurotoxicity Res. 4, 557–564.

    Article  CAS  Google Scholar 

  • Levine S and GW Lewis (1959) Critical period for the effects of infantile experience on maturation of stress.Science 129, 42–43.

    Article  PubMed  CAS  Google Scholar 

  • Lópes-Ibor JJ (2002) The classification of stress related disorders in ICD-10 and DSM-IV.Psychopathology 35, 107–111.

    Article  Google Scholar 

  • Lupien SJ, AR Lecours, I Lussier, G Schwartz, NP Nair and MG Meaney (1994) Basal cortical levels and cognitive deficits in human aging.J. Neurosci. 14, 2893–2903.

    PubMed  CAS  Google Scholar 

  • Lupien SJ, S Gaudreau, BM Tchiteya, F Maheu, S Sharma, NP Nair, RL Hauger, BS McEwen and MG Meaney (1997) Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity.J. Clin. Endocrinol. Metab. 82, 2070–2075.

    Article  PubMed  CAS  Google Scholar 

  • Lupien SJ, M de Leon, S de Santi, A Convit, C Tarshish, NP Nair, M Thakur, BS McEwen, RL Hauger and MG Meaney (1998) Cortisol levels during human aging predict hippocampal atrophy and memory deficits.Nature Neurosci. 1, 69–73.

    Article  PubMed  CAS  Google Scholar 

  • MacKinnon DF, KR Jamison and JR DePaulo (1997) Genetics of manic depressive illness.Annu. Rev. Neurosci. 20, 355–373.

    Article  PubMed  CAS  Google Scholar 

  • Magai C, C Cohen, D Gomberg, C Malatesta and C Culver (1996) Emotion expression in mid-to-late stage dementia.Int. Psychogeriatrica 8, 383–396.

    Article  CAS  Google Scholar 

  • Maier W, D Lichtermann, J Minges and R Heun (1992) Personality traits in subjects at risk for unipolar major depression: a family study perspective.J. Affect. Disord. 24, 153–163.

    Article  PubMed  CAS  Google Scholar 

  • Manzanares J, L Uriguen, G Rubio and T Palomo (2004) Role of endocannabinoid system in mental diseases.Neurtoxicity Res. 6, 213–224.

    Google Scholar 

  • McGaugh JL (2000) Memory — a century of consolidation.Science 287, 248–251.

    Article  PubMed  CAS  Google Scholar 

  • McGaugh JL, CK McIntyre, AE Power and B Roozendaal (2003) Role of the basolateral amygdala in memory consolidation.Ann. NY Acad. Sci. 985, 273–293.

    PubMed  Google Scholar 

  • McGee R, S Williams, R Poulton and T Moffitt (2000) A longitudinal study of cannabis use and mental health from adolescence to early adulthood.Addiction 95, 491–503.

    Article  PubMed  CAS  Google Scholar 

  • McKenna C (1997) Substance-induced psychiatric disorders, In:The Principles and Practice of Addictions in Psychiatry (Miller NS, Ed.) (Saunder Co.: Philadelphia, PA) pp 103–112.

    Google Scholar 

  • Melke J, M Landen, F Baghei, R Rosmond, G Holm, P Björntorp, L Westberg, M Hellstrand and E Eriksson (2001) Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women.Am. J. Med. Genet. 105, 458–463.

    Article  PubMed  CAS  Google Scholar 

  • Melvin GA and GN Molly (2000) Some psychometric properties of the Positive and Negative Affect Schedule among Australian youth.Psychol. Rep. 86, 1209–1212.

    Article  PubMed  CAS  Google Scholar 

  • Meyer GJ and JR Shack (1989) Structural convergence of mood and personality: evidence for new and old directions.J. Personal Soc. Psychol. 57, 691–706.

    Article  Google Scholar 

  • Milad MR and GJ Quirk (2002) Neurons in medial prefrontal cortex signal memory for fear extinction.Nature 420, 70–74.

    Article  PubMed  CAS  Google Scholar 

  • Mizoguchi K, M Yuzurihara, A Ishige, H Sasaki, DH Chui and T Tabira (2000) Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction.J. Neurosci. 20, 1568–1574.

    PubMed  CAS  Google Scholar 

  • Moita MAP, S Rosis, Y Zhou, JE LeDoux and HT Blair (2003) Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning.Neuron 37, 485–497.

    Article  PubMed  CAS  Google Scholar 

  • Moldin SO, T Reich and JP Rice (1991) Current perspectives on the genetics of unipolar depression.Behav. Genetics 21, 211–242.

    Article  CAS  Google Scholar 

  • Munera A, A Gruart, MD Munoz and JM Delgado-Garcia (2000) Scopolamine impairs information processing in the hippocampus and performance of a learned eyeblink response.Neurosci. Lett. 292, 33–36.

    Article  PubMed  CAS  Google Scholar 

  • Munera A, A Gruart, MD Munoz, R Fernandez-Mas and JM Delgado-Garcia (2001) Hippocampal pyramidal cells activity encodes conditioned stimulus predictive value during classical conditioning in alert cats.J. Neurophysiol. 86, 2571–2582.

    PubMed  CAS  Google Scholar 

  • Myers KM and M Davis (2002) Behavioural and neural analysis of extinction.Neuron 36, 567–584.

    Article  PubMed  CAS  Google Scholar 

  • Navarro M, E Hernandez, RM Munoz, I del Arco, MA Villanua, MR Carrera and F Rodriguez de Fonseca (1997) Acute administration of the CB1 receptor antagonist SR 141716A induces anxiety-like responses in the rat.Neuroreport 8, 491–496.

    Article  PubMed  CAS  Google Scholar 

  • Nemiah JC (1895) Phobic disorders, InComprehensive Textbook of Psychiatry, 4th Edition (Kaplan HI and BJ Sadock, Eds) (Williams and Wilkins: Baltimore, MD), pp 895–904.

    Google Scholar 

  • Newman SC (1999) The prevalence of depression in Alzheimer’s disease and vascular dementia in a population sample.J. Affect. Disord. 52, 169–176.

    Article  PubMed  CAS  Google Scholar 

  • Norlander T, SÅ Bood and T Archer (2002) Performance during stress: affective personality, age, and regularity of physical exercise.Social Behav. Personality 30, 495–508.

    Article  Google Scholar 

  • Norlander T, E Wästlund and T Archer (2004) Swedish norm group for PANAS. (Karlstad University: Karlstad, Sweden).

    Google Scholar 

  • Nuechterlein KH, RF Asarnow, KL Subotnik, DL Fogelson, DL Payne, KS Kendler, MC Neale, KC Jacobson and J Mintz (2002) The schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family study.Schizophr. Res. 54, 121–130.

    Article  PubMed  Google Scholar 

  • Ogrocki PK, AC Hills and SE Milton (2000) Visual exploration of facial emotion by healthy older adults and patients with Alzheimer disease.Neuropsychiatr. Neuropsychol. Behav. Neurol. 13, 271–278.

    CAS  Google Scholar 

  • O’Neill D (1997) Cogito ergo sum? Refocusing dementia ethics in a hyper-cognitive society.Ir. J. Psychol. Med. 14, 121–123.

    PubMed  Google Scholar 

  • Nyström S and B Lindegård (1975) Predisposition for mental syndromes: a study comparing predisposition for depression, neurasthenia and anxiety state.Acta Psychiatr. Scand. 51, 69–76.

    Article  PubMed  Google Scholar 

  • Palmer AM, GC Stratmann, AW Procter and DM Bowen (1988) Possible neurotransmitter basis of behavioral changes in Alzheimer’s disease.Ann. Neurol. 23, 616–620.

    Article  PubMed  CAS  Google Scholar 

  • Paquette V, J Levesque, B Mansour, JM Leroux, G Beaudoin, P Borgouin and M Beauregard (2003) Change the mind and you change the brain: effects of cognitive-behavioural therapy on the neural correlates of spider phobia.Neuroimage 18, 401–409.

    Article  PubMed  Google Scholar 

  • Park CL, LH Cohen and R Murch (1996) Assessment and prediction of stress-related growth.J. Personality 64, 71–105.

    Article  PubMed  CAS  Google Scholar 

  • Peacock JL, JM Bland and HR Anderson (1995) Preterm delivery-effects of socio-economic factors, psychological stress, smoking, alcohol and caffeine.Br. Med. J. 311, 531–535.

    CAS  Google Scholar 

  • Peper M, S Karcher, R Wohlfarth, G Reinshagen and JE LeDoux (2001) Aversion learning in patients with unilateral lesions of the amygdala and hippocampus.Biol. Psychol. 58, 1–23.

    Article  PubMed  CAS  Google Scholar 

  • Piazza PV and M Le Moal (1998) The role of stress in drug self-administration.Trends Pharmacol. Sci. 19, 67–74.

    Article  PubMed  CAS  Google Scholar 

  • Quirk GJ (2002) Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery.Learn. Mem. 9, 402–407.

    Article  PubMed  Google Scholar 

  • Quirk GJ, GK Russo, JL Barron and K Lebron (2000) The role of ventromedial prefrontal cortex in the recovery of extinguished fear.J. Neurosci. 20, 6225–6231.

    PubMed  CAS  Google Scholar 

  • Robson P (2001) Therapeutic aspects of cannabis and cannabinoids.Br. J. Psychiatr. 178, 107–115.

    Article  CAS  Google Scholar 

  • Rocher C, M Spedding, C Munoz and TM Jay (2004) Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants.Cereb. Cortex 14, 224–229.

    Article  PubMed  Google Scholar 

  • Rodriguez de Fonseca F, MR Carrera, M Navarro, GF Koob and F Weiss (1997) Activation of corticotrophin-releasing factor in the limbic system during cannabinoid withdrawal.Science 276, 2050–2054.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez-Moreno A, E Dominguez del Toro, E Porras-Garcia and JM Delgado-Garcia (2004) The use of alert behaving mice in the study of learning and memory processes.Neurotoxicity Res. 6, 225–232.

    Article  Google Scholar 

  • Roozendaal B, DJ de Quervain, B Ferry, B Setlow and JL McGaugh (2001) Basolateral amygdala — nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation.J. Neurosci. 21, 2518–2525.

    PubMed  CAS  Google Scholar 

  • Rosenthal D (1971) A program of research on heredity in schizophrenia.Behav. Science,16, 191–201.

    Article  CAS  Google Scholar 

  • Rothbaum BO and AC Schwartz (2002) Exposure therapy for post-traumatic stress disorder.Am. J. Psychother. 56, 59–75.

    PubMed  Google Scholar 

  • Santini E, RU Muller and GJ Quirk (2001) Consolidation of extinction learning involves transfer from NMDA-undependent to NMDA-dependent memory.J. Neurosci. 21, 9009–9017.

    PubMed  CAS  Google Scholar 

  • Schafe GE, CM Atkins, MW Swank, EP Bauer, JD Sweatt and JE LeDoux (2000) Activation of ERK/MAP kinase in the amygdale is required for memory consolidation of Pavlovian fear conditioning.J. Neurosci. 20, 8177–8187.

    PubMed  CAS  Google Scholar 

  • Schafe GE, K Nader, HT Blair and JE LeDoux (2001) Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective.TINS 24, 540–546.

    PubMed  CAS  Google Scholar 

  • Scheier MF and CS Carver (1985) Optimism, coping, and health: assessment and implications of generalized outcome expectancies.Health Psychol. 4, 219–247.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz N (2000) Emotion, cognition and decision making.Cogn. Emotion 14, 433–440.

    Article  Google Scholar 

  • Selkoe DJ (2002) Alzheimer’s disease is a synaptic failure.Science 298, 789–791.

    Article  PubMed  CAS  Google Scholar 

  • Shakesby AC, R Anwyl and MJ Rowan (2002) Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents.J. Neurosci. 22, 3638–3644.

    PubMed  CAS  Google Scholar 

  • Sheline YI, M Sanghavi, MA Mintun and MH Gado (1999) Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression.J. Neurosci. 19, 5034–5043.

    PubMed  CAS  Google Scholar 

  • Solowij N (1998)Cannabis and Cognitive Functioning (Cambridge University Press: Cambridge, UK).

    Google Scholar 

  • Solowij N, RS Stephens, RA Roffman, TF Babor, R Kadden, M Miller, K Christiansen, B McRee and J Vendetti (2002) Cognitive functioning of long-term heavy cannabis users seeking treatment.JAMA 287, 1123–1131.

    Article  PubMed  Google Scholar 

  • Speedie LJ, N Brake, SE Folstein, D Bowers and KM Heilman (1990) Comprehension of prosody in Huntington’s disease.J. Neurol. Neurosurg. Psychiatr. 53, 607–610.

    Article  PubMed  CAS  Google Scholar 

  • Spence MA, PL Flodman, AD Sadovnick, JE Bailey-Wilson, H Ameli and RA Remick (1995) Bipolar disorder: evidence for a major locus.Am. J. Med. Genet. 60, 370–376.

    Article  PubMed  CAS  Google Scholar 

  • Stokes G (1996) Challenging behaviour in dementia: a psychological approach, InHandbook of Clinical Psychology of Aging (Woods RT, Ed.) (Wiley: Chichester, UK) pp 601–628.

    Google Scholar 

  • Szapiro G, MRM Vianna, JL McGaugh, JH Medina and I Izquierdo (2003) The role of NMDA glutamate receptors, PKA, MAPK and CAMKII in the hippocampus in the extinction of conditioned fear.Hippocampus 13, 53–58.

    Article  PubMed  CAS  Google Scholar 

  • Szeszko PR, E Goldberg, H Gunduz-Bruce, M Ashtari, D Robinson, AK Malhotra, T Lencz, J Bates, DT Crandall, JM Kane and RM Bilder (2003) Small anterior hippocampal formation volume in antipsychotic naïve patients with first episode schizophrenia.Am. J. Psychiatr. 160, 2190–2197.

    Article  PubMed  Google Scholar 

  • Terry AV and JJ Buccafusco (2003) The cholinergic hypothesis of age and Alzheimer’s disease-related cognitive deficits: recent challenges and their implications for novel drug development.J. Pharmacol. Exp. Ther. 306, 821–827.

    Article  PubMed  CAS  Google Scholar 

  • Thomas H (1993) Psychiatric symptoms in cannabis users.Br. J. Psychiatry 163, 141–149.

    Article  PubMed  CAS  Google Scholar 

  • Trigo JA, A Gruart and JM Delgado-Garcia (1999) Discharge profiles of abducens, accessory abducens, and orbicularis oculi motoneurons during reflex and conditioned blinks in alert cats.J. Neurophysiol. 81, 1666–1684.

    PubMed  CAS  Google Scholar 

  • Trinh NH, J Hoblyn, S Mohanty and K Yaffe (2003) Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer’s disease: a meta-analysis.JAMA 289, 210–216.

    Article  PubMed  CAS  Google Scholar 

  • Van Praag HM (2002) Crossroads of corticotropin releasing hormone, corticosteroids and monoamines.Neurotoxicity Res.4(5–6), 531–555.

    Article  CAS  Google Scholar 

  • Varg N (1997)Negativ Affektivitets Inverkan på Svarsbeteende I Enkätformulär. [The influence of negative affect upon responses to questionnaires]. (Stockholm University: Stockholm).

    Google Scholar 

  • Vermetten E and JD Bremner (2002) Circuits and systems in stress. I Preclinical studies.Depress. Anxiety 15, 126–147.

    Article  PubMed  Google Scholar 

  • Vianna MRM, G Szapiro, JL McGaugh, JH Medina and I Izquierdo (2001) Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus.Proc. Natl. Acad. Sci. USA 98, 12251–12254.

    Article  PubMed  CAS  Google Scholar 

  • Vianna MRM, M Cammarota, AS Coitinho, JH Medina and I Izquierdo (2003a) Pharmacological studies on the molecular basis of memory extinction.Curr. Neuropharmacol. 1, 109–121.

    Article  Google Scholar 

  • Vianna MRM, AS Coitinho and I Izquierdo (2003b) Role of the hippocampus and baso-lateral amygdala in the extinction of fear conditioning.Curr. Neurovasc. Res. 1.

  • Vogel RW, M Ewers, C Ross, TJ Gould and DS Woodruff-Pak (2002) Age-related impairment in the 250-millisecond delay eye- blink classical conditioning procedure in C57/BL6 mice.Learn. Mem. 9, 321–336.

    Article  PubMed  Google Scholar 

  • Walker DL, KJ Ressler, KT Lu and M Davis (2002) Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine assessed with fear-potentiated startle in rats.J. Neurosci. 22, 2343–2351.

    PubMed  CAS  Google Scholar 

  • Watson D and L Clark (1984) Negative affectivity: the disposition to experience aversive negative states.Psychol. Bull. 96, 465–490.

    Article  PubMed  CAS  Google Scholar 

  • Watson D and A Tellegen (1985) Toward a consensual structure of mood.Psychol. Bull. 98, 219–235.

    Article  PubMed  CAS  Google Scholar 

  • Watson D, JW Pennebaker and R Folger (1987) Beyond negative affectivity: measuring stress and satisfaction in the workplace.J. Organisational Behav. Manage. 8, 141–157.

    Article  Google Scholar 

  • Watson D, LA Clark and G Carey (1988a) Positive and negative affectivity and their relation to anxiety and depressive disorders.J. Abnorm. Psychol. 97, 346–353.

    Article  PubMed  CAS  Google Scholar 

  • Watson D, LA Clark and A Tellegen (1988b) Development and validation of brief measures of positive and negative affect: the PANAS scales.J. Pers. Soc. Psychol. 54, 1063–1070.

    Article  PubMed  CAS  Google Scholar 

  • Weidenfeld J, S Feldman and R Mechoulam (1994) Effect of the brain constituent anandamide, a cannabinoid receptor agonist, on the hypothalamo-pituitary-adrenal axis in the rat.Neuroendocrinology 59, 110–112.

    Article  PubMed  CAS  Google Scholar 

  • Wetzel RD, CR Cloninger, B Hong and T Reich (1980) Personality as a subclinical expression of the affective disorders.Compr. Psychiatr. 21, 197–205.

    Article  CAS  Google Scholar 

  • Wilensky AE, GE Schafe and JE LeDoux (2000) The amygdale modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning.J. Neurosci. 20, 7059–7066.

    PubMed  CAS  Google Scholar 

  • Wilson K, E Gullone and S Moss (1998) The youth version of the positive and negative affect schedule: a psychometric validation.Behav. Change 15, 187–193.

    Google Scholar 

  • Woods B (1999)Psychological Problems of Aging (Wiley: Chichester, UK).

    Google Scholar 

  • Woods RT (2001) Discovering the person with Alzheimer’s disease: cognitive, emotional and behavioural aspects.Aging Ment. Health 5, S7-S16.

    Article  PubMed  Google Scholar 

  • Yaniv D, GE Schafe, JE LeDoux and G Richter-Levin (2001) A gradient of plasticity in the amygdala revealed by cortical and sub-cortical stimulation,in vivo. Neuroscience 106, 613–620.

    Article  CAS  Google Scholar 

  • Zevon MA and A Tellegen (1982) The structure of mood change: an idiographic/nomothetic analysis.J. Personal Soc. Psychol. 43, 111–122.

    Article  Google Scholar 

  • Zigmond AS and RP Snaith (1983) The Hospital Anxiety and Depression Scale.Acta Psychiatr. Scand. 67, 361–370.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Servicio Psiquiátrico, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041, Madrid, Spain

    T. Palomo

  2. Departments of Psychology and Psychiatry, Queen’s Univ., K7L 3N6, Kingston, ON, Canada

    R. J. Beninger

  3. Department of Pharmacology, Quillen College of Medicine, East Tennessee State Univ., 37614, Johnson City, TN, USA

    R. M. Kostrzewa

  4. Department of Psychology, University of Göteborg, Box 500, SE-40530, Göteborg, Sweden

    T. Archer

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  2. R. J. Beninger
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  4. T. Archer
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Palomo, T., Beninger, R.J., Kostrzewa, R.M. et al. Gene-environment interplay in affect and dementia: Emotional modulation of cognitive expression in personal outcomes. neurotox res 6, 159–173 (2004). https://doi.org/10.1007/BF03033219

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