Abstract
Discrimination between strontium (Sr) and calcium (Ca) was examined in suckling rats and compared with that in older rats after weaning. Concentrations of Sr and Ca and the Sr/Ca ratios in serum and femur of 10-d old and 21-d old rats were determined. The Sr concentrations and Sr/Ca ratios in the serum and femur of 10-d old rats were lower than those of 21-d old rats, that could be explained by the fact that 10-d old rats ingested only maternal milk in which the Sr/Ca ratio was much lower than the laboratory diet. The relative ratios of Sr/Ca in serum and femur to that in the diet were found to be higher in 10-d old rats compared with those in 21-d old rats, and also higher than those in the older rats after weaning, as described in our previous publication. This result may reflect that discrimination between Sr and Ca during intestinal absorption is lacking in very young animals before weaning and develops after this age. Renal discrimination between Sr and Ca in the suckling rats at 10 d of age was evaluated by determining the relationship between the relative clearances of Ca and Sr. The mathematical model proposed by Walser and Robinson was applied on these results and the parameter for the equation, that is, the discrimination constant, was shown to be higher in 10-d old rats compared to those in young (7 wk of age) and adult (25 wk of age) rats. This result suggests that the discrimination of Sr in favor of Ca during the tubular reabsorptive process may not be fully developed in the very young rats before weaning.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
R. H. Wasserman, E. M. Romney, M. W. Skougstad, and R. Siever,Geochemistry and the Environment.Vol. 2, Natl. Acad. Sci., Washington, DC, (1977), pp. 73–87.
G. W. Dolphin and I. S. Eve,Phys. Med. Biol 8, 193 (1963).
C. L. Comar and R. H. Wasserman,Mineral Metabolism: An Advanced Treatise, C. L. Comar and F. Bronner, eds., Academic, New York, (1964), pp. 523–572.
C. L. Comar,Strontium Metabolism, J. M. A. Lenihan, J. F. Loutit, and J. H. Martin, eds., Academic, New York, (1967), pp. 17–31.
N. Sugihira and K. T. Suzuki,Biol. Trace Elem. Res. 22, 71 (1989).
N. Sugihira, E. Kobayashi, and K. T. Suzuki,Biol. Trace Elem. Res.,25, 79 (1990).
N. Sugihira and K. T. Suzuki,Trace Elem. Med.,7, 33, (1990).
D. M. Taylor, P. H. Bligh, and M. H. Duggan,Biochem. J. 83, 25 (1962).
R. F. Palmer and R. C. Thompson,Proc. Soc. Exp. Biol. Med. 108, 296 (1961).
C. L. Comar, R. H. Wasserman, S. Ullberg, and G. A. Andrews,Proc. Soc. Exp. Biol. Med. 95, 386 (1957).
H. Spencer, D. Laszlo, and M. Brothers,J. Clin. Invest. 36, 680 (1957).
F. Bronner, J.-P. Aubert, L. J. Richelle, P. D. Saville, J. A. Nicholas, and J. R. Cobb,J. Clin. Invest. 42, 1095 (1963).
M. Walser and B. H. B. Robinson,Bull. Johns Hopkins Hosp. 111, 20 (1962).
G. B. Forbes and J. C. Reina,J. Nutr. 102, 647 (1972).
C. Robles-Valdes, J. D. McGarry, and D. W. Foster,J. Biol. Chem. 251, 6007 (1976).
R. W. Bonsnes and H. H. Taussky,J. Biol. Chem. 158 581 (1945).
E. Kobayashi, N. Sugihira, and K. T. Suzuki,Biol. Trace Elem. Res., in press.
P. Gmaj, H. Murer, and R. Kinne,Biochem. J 178, 549 (1979).
Z. Talor and J. A. L. Arruda,Miner. Electrolyte Metab. 12, 239 (1986).
P. Gmaj, H. Murer, and E. Carafoli,FEBS Lett. 144, 226 (1982).
M. P. E. van Heeswijk, J. A. M. Geertsen, and C. H. van Os,J. Membrane Biol. 79, 19 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sugihira, N., Suzuki, K.T. Discrimination between strontium and calcium in suckling rats. Biol Trace Elem Res 29, 1–10 (1991). https://doi.org/10.1007/BF03032669
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03032669