Summary
Forane (Compound 469) is a stable, non-explosive, halogenated ether compound similar in structure to enflurane (Ēthrane). We found that it had effective and safe anaesthetic properties when tested in small, purebred animals (mice, rats, rabbits, beagle dogs, and rhesus monkeys).
This study was undertaken to compare the effects of a vapour concentration of 2mac of Forane in oxygen, after thiopentone induction, with those of enflurane, halothane, and methoxyflurane on vital functions and biochemical blood tests, employing a cross-over experiment in 12 large, healthy, mongrel dogs.
The clinical observations showed that Forane is an effective anaesthetic that acts rapidly, does not provoke cardiac ventricular arrhythmias, neuromuscular disturbances, or airway secretions. Recovery is rapid and smooth. Aside from a moderate elevation of blood sugar and plasma cortisol and reduction of free fatty acids, as seen with the other halogenated anaesthetics, no significant changes in the blood chemistries, electrolytes, or acid-base balance occurred. This study indicated that Forane would be useful and safe for humans.
Résumé
Forane est un éther halogéné stable, non-explosif, d'une structure ressemblant à celle de l'enflurane (Ēthrane). Nous avons constaté que le Forane est doué de qualités anesthésiques efficaces et sûres chez des animaux de laboratoire de pur sang (souris, rats, lapins, bigles, et singes rhésus).
Ce travail compare les effets des vapeurs de Forane à concentration de 2mac dans l'oxygène avec ceux de l'enflurane, halothane et methoxyflurane après l'induction au pentothal. Nous avons fait une série de tests croisés sur 12 gros chiens mâles métis en bonne santé dont les paramètres physiologiques et biochimiques étaient suivis.
Nos observations cliniques démontrent que le Forane possède une action rapide, ne cause pas d'arythmies ventriculaires, ni perturbations neuromusculaires ni sécrétions dans les voies respiratoires. Le réveil est rapide et doux. En dehors d'une élévation modérée du sucre sanguin, du cortisole plasmatique ainsi que d'une baisse des acides graisseux libres, vues d'ailleurs avec les autres agents halogénés, il n'y avait pas de changements significatifs de la biochimie du sang, des substances endocrines, des électrolytes ni de l'équilibre acide-base. Ce travail montre que le Forane peut être un anesthésique utile et sûr chez l'homme.
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References
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Trademark of Ohio Medical Products, Division of Air Reduction Co, Inc, Murray Hill, N.J.
This work was supported in part by the Division of Research Facilities and Resources ofnih through grantfr 00353 and by the Ohio Medical Products Division of Air Reduction Co, Inc. Madison, Wisconsin.
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Byles, P.H., Dobkin, A.B., Ferguson, J.H. et al. Forane (Compound 469): Cross-over comparison with enflurane (Ēthrane), halothane, and methoxyflurane in dogs. Canad. Anaesth. Soc. J. 18, 376–386 (1971). https://doi.org/10.1007/BF03025689
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DOI: https://doi.org/10.1007/BF03025689