Summary
Continuous dynamic recordings were obtained in 28 experiments from electromagnetic flow meter probes chronically implanted on the ascending aorta of mongrel dogs. Anaesthesia was induced with Surital, maintained with 1 per cent halothane and followed by subsequent injections of d-tybocurarine (dtc). Cardiac output studies were designed to separate the effects ofdtc.and histamine and compare with antihistamine and with the effects ofdtc in histamine-depleted dogs prepared by Brocresine (nsd 1055), a histamine synthesis inhibitor.
dtc decreased cardiac output to 56 per cent of control at five minutes associated with a concomitant fall in the mean arterial pressure to 60 per cent of control value at one minute after injection respectively. These changes in the dog appear to be due to action of endogenous histamine released by the d-tubocurarine.
Résumé
Nous avons fait des enregistrements dynamiques continus au cours de 28 expériences (obtenues) avec des appareils débit-mètres électromagnétiques implantés à demeure dans l’aorte ascendante de chiens mongrels. L’induction de l’anesthésie s’est faite au surital, et l’anesthésie a été maintenue à l’halothane 1 pour cent et à l’aide d’injections subséquentes de d-tubocurarine. Les études du débit cardiaque étaient destinées à réparer les effets de ladtc et de l’histamine et de les comparer à ceux de l’antihistamine et à ceux de ladtc chez les chiens privés d’histamine par la brocrésine (nds 1055), un inhibiteur de synthèse de l’histamine.
Ladtc a diminuè le débit cardiaque à 56 pour cent du contrôle obtenu après 5 minutes, ceci associé à une chute concomittante de la pression artérielle moyenne à 60 pour cent du contrôle obtenu une minute après l’injection. Ces changements chez le chien semblent dûs à l’action de l’histamine endogène libérée par la d-tubocurarine.
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This study was supported in part by Washington State Heart Association, grant #6667-8. Halothane was supplied by Ayerst Laboratories. Brocresine was supplied by Lederle Laboratories.
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Lee, D., Johnson, D.L. Effect of d-tubocurarine and anaesthesia upon cardiac output in normal and histamine-depleted dogs. Canad. Anaesth. Soc. J. 18, 157–165 (1971). https://doi.org/10.1007/BF03025445
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DOI: https://doi.org/10.1007/BF03025445