Summary
A method which has been developed for the satisfactory estimation of procaine in whole blood avoids the loss of procaine which was apparent in methods where blood proteins were precipitated by use of trichloroacetic acid. Approximately 85 per cent of the added procaine was constantly recovered by this method from test samples of blood and the procedure was considered to be satisfactory for determining concentrations of procaine m patients’ blood The peak concentration of procaine m blood twenty minutes after the infiltration of procaine (2.06-3.7 gm) varied from 0 7 ¼g to 50 ¼g. per gram of blood m the patients studied
Résumé
Nous avons mis au pomt une méthode precise pour mesurer, dans le sang total, la quantité de procaine qui s’y trouve à la suite de filtratlons locales de procaine au cours de la chirurgie. Nous exposons les progrès de cette méthode et citons les publications de ďautres méthodes. Nous avons recouvré 85% de la procame ajoutée à des échantillons de sang humain total, ce qui indique bien que cette méthode est satisfaisante.
La concentration maximale de procame, variant entre 07 mg. et 5.0 mg. par gramme de sang humain total, a été atteinte environ vingt mmutes après ľinfiltration souscutanée de chlorhydrat e de procaine ( 206 à 37 gm. ) chez des malades subissant une cure de hernie.
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The data included herein were taken in part from a Thesis submitted in partial fulfilment of the requirements for the degree of Doctor, Philosophy, University of Toronto, May, 1957.
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Mayxut, M.O. A reliable colorimetric method for the quantitative determination of procaine in human whole blood. Canad. Anaesth. Soc. J. 6, 159–168 (1959). https://doi.org/10.1007/BF03014213
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DOI: https://doi.org/10.1007/BF03014213