Abstract
The comparative efficacy of intravenous cimetidine and ranitidine in controlling gastric pH in 100 intensive care unit patients was assessed in a double blind, prospective, randomized study. The total number of gastric pH determinations and the number of pH determinations with pH less than five were recorded. Patients received either cimetidine or ranitidine via continuous infusion, with dosage adjustments for patients with renal insufficiency. Antacids were administered each time the gastric pH was less than five. There was no difference overall in the number of patients who had at least one gastric pH determination < pH 5. There was however, a larger proportion of patients with ≥10, ≥15, ≥20 and ≥25 per cent of gastric pH determination < pH 5 in the cimetidine group than in the ranitidine group. This difference was statistically significant for ≥25 per cent. The drugs were well tolerated. Ranitidine was as effective as cimetidine and possibly more so in controlling gastric pH.
Résumé
L’efficacité relative d’un traitement intraveineaux à la cimetidine et ranitidine dans le contrôle pH gastrique est e’tudiée chez 100 patients des soins intensifs. Cette étude prospective est à double insu et randomisée. Le nombre total des mesures du pH gastrique ainsi que le nombre des mesures du pH inférieur à cinq était enregistré. Les patients ont reçu soit de la cimetidine soit de la ranitidine en perfusion continue avec des ajustements de dosage pour les patients en insuffisance rénale. Des antacides ont été administrés chaque fois que le pH gastrique était inférieur à cinq. Il n’y avait aucune différence dans le nombre de patient qui ont présenté au moins un seul pH gastrique inférieur à cinq. Il y avait cependant une grande proportion de patients dans le groupe cimetidine pour qui les déterminations d’ un pH gastrique inférieur à cinq étaient de ≥ 10, ≥15, ≥20, et ≥25 pour cent. Cette différence entre les deux groupes n’était statistiquement significative que pour les déterminations ≥25 pour cent. Les médicaments étaient bien tolérés. La ranitidine était aussi ejficace que la cimétidine et possiblement plus dans le contrôle du pH gastrique.
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Reid, S.R., Bayliff, C.D. The comparative efficacy of cimetidine and ranitidine in controlling gastric pH in critically ill patients. Can Anaesth Soc J 33, 287–293 (1986). https://doi.org/10.1007/BF03010739
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DOI: https://doi.org/10.1007/BF03010739