Abstract
The aim of this study was to examine differences in prejunctional effects of different relaxants by measuring the train-offour (TOF) fade during the onset and recovery of neuromuscular block. The relaxants studied were atracurium (225 μg · kg−1), mivacurium (65 μg · kg−1) rocuronium (300 μg · kg−1)) and vecuronium (40 μg · kg−1)). The TOF ratios were measured at approximate heights of T1) (first response in the TOF) of 90, 75, 50, and 25%. The TOF fade (as shown by lower TOF ratios) increased with a decrease in the T1) during onset of neuromuscular block. Although there was a slightly greater fade with atracurium and rocuronium during the onset of block, the differences among the relaxants were insignificant. It is concluded that the relative prejunctional effects of these relaxants are similar.
Résumé
Ce travail cherche à évaluer la différences entre les effets préjonctionnels de plusieurs myorelaxants par la mesure de l’affaiblissement (fade) de la réponse au train-de-quatre (TOF) pendant l’établissement et la récupération du bloc neuromusculaire. Les relaxants étudiés sont l’atracurium (225 μg · kg−1)), le mivacurium (65 μg · kg−1)), le rocuronium (300 μg · kg−1)) et le vécuronium (40 μg · kg−1)). Les rapports du TOF sont mesurés avec la hauteur approximative du T1) (première réponse au TOF) de 90, 75, 50 et 25%. L’affaiblissement du TOF (montré par la baisse du ratio) augmente avec la baisse de T1) pendant l’établissement du bloc neuromusculaire. Bien que l’affaiblissement soit plus grand avec l’atracurium et le rocuronium pendant l’établissement du bloc, les différences entre myorelaxants ne sont pas significatives. On conclut que les effets préjonctionnels relatifs de ces myorelaxants sont identiques.
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Dr. McCoy was supported by a Research Fellowship from the Gifts and Endowments Fund of the Royal Hospitals Trust.
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McCoy, É.P., Connolly, F.M., Mirakhur, R.K. et al. Nondepolarizing neuromuscular blocking drugs and train-of-four fade. Can J Anaesth 42, 213–216 (1995). https://doi.org/10.1007/BF03010679
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DOI: https://doi.org/10.1007/BF03010679