Abstract
Because of discrepancy in reports concerning the rate of uptake of nitrous oxide by man, it seemed desirable to measure this factor when automatic control of concentrations and rapid computer measurement of breath to breath uptake became available. Six subjects inhaled 25 per cent nitrous oxide for two hours. Total uptake and alveolar uptake were determined. The total inhaled uptake, adjusted for a 70 kg subject inhaling 75 per cent nitrous oxide, corresponded well with an absorption of about 1000 ml the first minute. After a wash-in period of less than four minutes, the alveolar uptake, which at that time and subsequently equaled the total uptake, decreased approximately according to the square root of time in minutes. Considerable variation appeared between individuals, but each course approximated the same type of decrease. Absorption continued to occur during the two hour period of observation.
Résumé
C’est en constatant la discordance entre les résultats des études de mesure de la captation du protoxyde d’azote chez l’homme qu’il est apparu désirable de reprender ces mesures de façon plus précise en utilisant le contrôle automatique des concentration avec la mesure rapide de la captation par cycle respiratoire. On a fait inhaler du protoxyde d’azote à 25 pour cent à six sujets. Les captations totale et alvéolaire ont été mesurées. La captation inhalée totale ajustée pour un sujet de 70 kg inspirant une concentration de protoxyde d’azote à 75 pour cent correspondait bien avec une absorption de 1000 ml à la première minute. Après une période de moins de quatre minutes, la captation alvéolaire qui à ce moment et subséquemment égalait la captation totale, a diminué à une vitesse se rapprochant la racine carrée du temps en minute. Les variations individuelles ont été considérables mais la forme de la courbe de déclin était à peu prés identique chez tous les sujets. L’absorption s’est continuée pendant la période de deux heures.
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This study was supported in part by Grant HL-22978 from the National Heart, Lung, and Blood Institute.
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Virtue, R., Sherrill, D.L. & Swanson, G.D. Uptake of nitrous oxide by man. Canad. Anaesth. Soc. J. 29, 424–427 (1982). https://doi.org/10.1007/BF03009403
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DOI: https://doi.org/10.1007/BF03009403