Summary
A new technique for reducing bleeding during partial hepatectomy has been investigated in dogs. It consists of producing systemic hypotension using trime-thaphan alone, and in combination with Vasopressin. Hypotension of 20 minutes and resection of 35 per cent of liver substance produced minimal bleeding and insignificant effects on liver function. Further studies are in progress to determine the effects on liver function of hypotension up to 45 minutes in duration and to learn the significance of liver shunts and sphincter mechanisms. Preliminary results are briefly discussed. The hepatic artery flow is dependent on mean aortic pressure. The clinical usefulness of this technique is discussed.
Résumé
Nous avons étudié une nouvelle technique pour réduire les pertes sanguines au cours de l’hépatectomie partielle. Nous avons examiné sur des chiens l’effet de l’hypotension systémique en employant seul le trimethaphan et en l’associant à la Vasopressine. Une hypotension d’une durée de 20 minutes et une amputation de 35 pour cent de la substance hépatique n’ont produit que des pertes sanguines minimes et des effets négligeables sur la fonction hépatique. D’autres études sont actuellement en cours pour préciser les effets sur la fonction hépatique d’une hypotension se prolongeant jusqu’à 45 minutes ainsi que la signification des dérivations hépatiques et des mécanismes des sphincters. Nous avons brièvement discuté les résultats préléminaires. Le débit de l’artère hépatique est régi par la pression moyenne dans l’aorte. Nous avons parlé de l’utilité clinique de cette technique.
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Davies, J.I., Kaplan, A. Anaesthetic and surgical considerations in partial hepatectomy. Can. Anaesth. Soc. J. 15, 267–275 (1968). https://doi.org/10.1007/BF03008739
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DOI: https://doi.org/10.1007/BF03008739