Abstract
The purpose of this study was to evaluate epinephrine-aminophylline-induced arrhythmias during halothane anaesthesia after induction with thiopentone or midazolam. Ten mongrel dogs were studied during 1 MAC halothane and 50% N2O:O2 anaesthesia while maintaining constant acid-base status. The minimal arrhythmogenic infusion rate of epinephrine (MAIRE) and the corresponding plasma concentration of epinephrine (MAPC) required to produce ventricular arrhythmias before and after aminophylline were higher following induction of anaesthesia with midazolam than with thiopentone (P < 0.05); the MAIREs decreased stepwise with aminophylline (P < 0.05). The correlation coefficient between individual MAIREs and MAPCs was 0.93 (P < 0.001). Epinephrine alone and in combination with aminophylline was less arrhythmogenic after induction with midazolam than with thiopentone.
Résumé
Cette étude fut entreprise pour comparer l’ effet de l’ induction de l’ anesthésie au midazolam à l’effet de l’induction au thiopentone sur l’arythmogénicité de l’ épinéphrine tant en l’absence qu’en la présence d’aminophylline. Cinq chiens reçurent 10 mg · kg−1 de midazolam intraveineux. Cinq autres reçurent 25 à 30 mg · kg−1 de thiopentone. Après intubation trachéale, tous furent gardés sous anesthésie à l’ aide de 1 MAC d’ halothane dans un mélange de 50% de N2O et d’O2. Les taux minimaux d’infusion d’ épinéphrine (MAIRE) requis pour produire des arythmies ventriculaires et les concentrations plasmatiques d’ épinéphrine correspondantes (MAPC) diminuèrent graduellement après 10 et 20 mg · kg−1 d’ aminophylline mais furent toujours plus élevés après l’induction au midazolam qu’ après l’induction au thiopentone. Donc, sous nos conditions expérimentales et comparée au thiopentone, l’induction au midazolam atténue l’ arythmogénicité de l’ épinéphrine tant en l’absence qu’ en la présence d’aminophylline.
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Supported by grants from the American Heart Association Northeast Ohio Chapter, the Heaton-Pennington Fund, and University Anesthesiologists, Inc.
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Lina, A.A., Dauchot, P.J. & Anton, A.H. Epinephrine-aminophylline-induced arrhythmias after midazolam or thiopentone in halothane-anaesthetized dogs. Can J Anaesth 38, 1037–1042 (1991). https://doi.org/10.1007/BF03008623
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DOI: https://doi.org/10.1007/BF03008623