Summary
The haemodynamic changes during 30 minutes of apnoeic oxygenation were studied in six intact dogs (group 1) and in 6 with hearts pharmacologically denervated by intravenous atropine and propranolol (group 2), using pentobarbital and succinylcholine anaesthesia. Progressive bradycardia was observed in both groups, but other parameters differed. In group 1 the mean central venous and intra-arterial pressures rose slightly and the cardiac output also rose. In group 2 the mean central venous pressure rose to abnormally high levels, while the mean intra-arterial pressure fell; the cardiac output was depressed in five dogs, while in the sixth it returned to slightly above the control values after an initial fall. Dogs with a pharmacologically denervated heart withstood 30 minutes of apnoeic oxygenation poorly.
RéSUMé
On a étudié les changements hémodynamiques au cours de 30 minutes d’oxygénation en apnée de six chiens normaux (groupe 1) et de six chiens au cœur énervé pharmacologiquement par l’administration intraveineuse d’atropine et de propranolol (groupe 2), au cours d’une anesthésie au pentothal et succinylcholine.
On a observé une bradycardie progressive chez les deux groupes, mais les autres paramètres ont été différents. Dans le groupe 1, les pressions veineuse centrale et intra-artérielle moyennes ont augmenté légèrement; le débit cardiaque aussi a augmenté. Dans le groupe 2, la pression veineuse centrale moyenne a atteint des niveaux élevés au dessus de la normale, alors que la pression intraartérielle moyenne s’est abaissée. Cinq chiens ont vu leur débit cardiaque diminuer; pour le sixième, après une baisse initiale, le débit cardiaque est remonté légèrement au dessus de la normale. Les chiens au cceur pharmacologiquement énervé ont mal supporté les 30 minutes d’oxygénation en apnée.
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This study was supported in part by grants received from Ayerst, McKenna, and Harrison, who also supplied the propranolol.
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Sun, S., FlNLAYSON, D.C. Haemodynamic changes during apnoeic oxygenation in dogs: Comparison between the intact and the pharmacologically denervated heart. Can. Anaes. Soc. J. 16, 18–26 (1969). https://doi.org/10.1007/BF03005774
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DOI: https://doi.org/10.1007/BF03005774