Abstract
Plasma lidocaine concentrations were measured over a five-hour period in 20 patients following continuous epidural infusion of lidocaine for surgical anaesthesia. Patients were divided into two groups: Group I received plain lidocaine; Group II received lidocaine with epinephrine. Patients initially received 10 ml followed by a constant infusion of 10 ml · hr-1 of two per cent lidocaine. The mean plasma concentrations of lidocaine were significantly higher for the first 40 min in Group I than in Group II. However, from one to five hours, there was no significant difference between the groups. These results demonstrate that the addition of epinephrine to lidocaine does not decrease the plasma concentration of lidocaine during continuous epidural infusion for long operations.
Résumé
Des concentrations plasmatiques de lidocaine ont été mesurées pour une période de cinq heures chez 20 patients après une perfusion continue dans l’espace epidural de lidocaine pour une anesthésie chirurgicale. Les patients furent divisés en deux groupes: Le groupe I a reçu de la lidocaine simple, le groupe II a reçu de la lidocaine avec épinéphrine. Les patients initialement ont reçu 10 ml suivi d’une perfusion continue de 10 ml· hr- 1 de deux pour cent de lidocaine. La concentration plasmatique moyenne de lidocaïne etait significativement supérieure pour les premières 40 minutes dans le groupe I comparativement au groupe II. Cependant si on compare la première à la cinquième heure, il n’y avait aucune différence significative entre les deux groupes. Ces résultats démontrent que Iaddition d’épinéphrine à la lidocaïne ne diminue pas la concentration plasmatique de lidocaïne lors de la perfusion continue dans l’espace épidural de lidocaïne pour des longues opérations.
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Takasaki, M., Kajitani, H. Plasma lidocaine concentrations during continuous epidural infusion of lidocaine with and without epinephrine. Can J Anaesth 37, 166–169 (1990). https://doi.org/10.1007/BF03005464
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DOI: https://doi.org/10.1007/BF03005464