Abstract
A homeostatic conditional reflex (CR) was elaborated to the effect of repeated inhalations in rats of a gas mixture containing 8 per cent oxygen. The effect of the conditional response was opposite to that of the unconditional one. After ablation of the frontal cortex, the conditional reaction disappeared. The repeated administration of 40 mg/kg of histamine resulted in a tolerance to the temperature lowering effect of histamine similar to the habituation. An injection of distilled water brought about dishabituation. Tolerance was not influenced by the ablation of the frontal cortex, but the dishabituating effect of distilled water was absent.
Similar content being viewed by others
References
Brutkowski, S.: Functions of prefrontal cortex in animals.Physiol. Rev.,45:721, 1965.
Cmiral, J., Dvorak, J. and Moravek, M.: The dynamic analysis of human reactions to repeated hypoxia by a parallel model.Physiol. Bohemoslov.,21:375, 1972.
Flückiger, E.: Der Sauerstoffverbrauch der Ratte bei vermindertem Sauerstoffpartialdruck.Helv. Physiol. Pharmacol. Acta,14:369, 1956.
Fuster, J. M.: Unit activity in prefrontal cortex during delayed-response performance: Neuronal correlates of transient memory.J. Neurophysiol.,36:61, 1973.
Fuster, J. M. and Bauer, R. H.: Visual short-term memory deficit from hypothermia of frontal cortex.Brain Res.,81:393, 1974.
Gantt, W. H.: Pharmacological agents in the study of higher nervous activity. XX-th International Physiological Congress. Brussels.Abstr. Communications p. 322, 1956.
Gerbner, F. and Pasztor, E.: The role of the frontal lobe in conditioned reflex activity.Acta Physiol. Acad. Sci. Hung.,26:89, 1965.
Glaser, E. M. and Griffin, J. P.: Influence of the cerebral cortex in habituation.J. Physiol. Lond.,160:429, 1962.
Grastyán, E.: Orientation and Reinforcement. Doctoral Thesis. Pécs. Hungary. 1975.
Herr, F.: Histamingewöhnung bei Ratten, II.Acta Physiol. Acad. Sci. Hung.,2:189, 1951.
Herr, F. and Pórszász, J.: Rasche Gewöhnung an Histamin und eine neue Methode zur Prüfung der Magensäuresekretion an Ratten.Acta Physiol. Acad. Sci. Hung.,2:17, 1951.
Jancsó, N.: Speicherung. Stoffanreicherung im Retikuloendothel und in der Niere. Budapest, Akadémiai Kiadó, 1955, p. 371.
Konorsky, J.: The cortical “representation” of unconditioned reflexes.Electroenceph. Clin. Neurophysiol., Suppl. 13:81, 1960.
Konorsky, J. and Lawicka, W.: Analysis of errors by prefrontal animals on the delayed-response test.In Warren, J. M. and Akert, K. (eds.): The Frontal Granular Cortex and Behavior. New York, McGraw-Hill Book Co., 1964.
Lynch, J. J., Fertziger, A. P., Teitelbaum, H. A., Cullen, J. W. and Gantt, W. H.: Pavlovian conditioning of drug reactions: Some implications for problems of drug addiction.Cond. Reflex,8:211, 1973.
Madarász, I., Obál, F., Vicsay, M. and Takács, Ö.: Analysis of the vegetative and EEG responses to hypoxia.Acta Physiol. Acad. Sci. Hung.,28:77, 1965.
Miles, R.: Learning by squirrel monkeys with frontal lesions.In Warren, J. M. and Akert, K. (eds.): The Frontal Granular Cortex and Behavior. New York, McGraw-Hill Book Co., 1964.
Newton, J. E. O. and Gantt, W. H.: One-trial cardiac conditioning in dogs.Cond. Reflex,1:251, 1966.
Nitulescu, J. and Foni, J.: Untersuchung zur Kontrolle der Grosshimrinde über das glykämische Gleichgewicht.Dtsch. Gesundh. Wes.,11:113, 1956.
Norman, R. J., Villablanca, J. R., Brown, K. A., Schwafel, J. A. and Buchwald, J.S.: Classical Eyeblink Conditioning in the bilaterally hemispherectomized cat.Exp. Neurol.,44:363, 1974.
Obál, F.: The fundamentals of the central nervous control of vegetative homeostasis.Acta Physiol. Acad. Sci. Hung.,30:15, 1966.
Obál, F., Mozes, M. and Erdei, P.: Die Rolle des Nervensystems in der Wirkung stoffwechselsteigernder Stoffe von verschiedener Wirkungsweise.Acta Physiol. Acad. Sci. Hung.,7:245, 1955.
Obál, F. and Vicsay, M.: The role of the nervous system in the adaptation of oxygen consumption to hypoxia.Acta Physiol. Acad. Sci Hung., Suppl. 22:18, 1963.
Obál, F., Vicsay, M., Benedek, G. and Szabó, J.: On the role of the frontal cortex in the vegetative behaviour. Proceedings of the International Union of Physiological Sciences. 25th International Congress. Munich. Vol.9:1257, 1971.
Obál, F., Vicsay, M. and Madarász, I.: Role of a central nervous mechanism in the acquired tolerance to the temperature decreasing effect of histamine.Acta Physiol. Acad. Sci. Hung.,28:65, 1965.
Pásztor, E. and Gerbner, M.: The role of the frontal lobe in the food-acquiring behaviour of the dog.Acta Physiol. Acad. Sci. Hung.,26:97, 1965.
Rzoska, J.: Bait shyness, a study in rat behaviour.Br. J. Anim. Behav.,1:128, 1953.
Strumza, M. and Binet, L.: La polyglobulie asphyxique, son degrée sa généralité.Le Sang,9:930, 1935.
Such, G., Vicsay, M., Szabó, É., Benedek, G. and Obál, F.: Biochemical changes associated with conditioned reflexes established upon hypoxia.Acta Physiol. Acad. Sci. Hung.,40:381, 1971.
Voitkevits, V. I.: Regulation of blood oxygen saturation by means of conditioned reflexes.Fiziol. zh. Leningr., (Russ.),38:452, 1952.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Obal, F., Benedek, G., Obal, F. et al. Data on the role of the frontal cortex in vegetative behavior. Pav. J. Biol. Sci. 13, 13–21 (1978). https://doi.org/10.1007/BF03005152
Issue Date:
DOI: https://doi.org/10.1007/BF03005152