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The effects of glucagon on the exocrine secretion of the perfused canine pancreas

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Summary

VOLUME, amylase, lipase and trypsin secretion in the totally isolated canine pancreas were studied. Glucagon does not have an inhibitory effect on the secretin or CCK-Pz evoked exocrine secretion of the isolated gland. In the gland stimulated by large combined doses of secretin and CCK-Pz, glucagon increases enzyme secretion. These findings may indicate that the inhibitory action of glucagon in the intact animal is indirect.

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References

  • Ceska, M., Hultman, E. and Ingelman, B. G. A. 1969. A new method for the detemination of α-amylase. Experientia, 25, 555.

    Article  PubMed  CAS  Google Scholar 

  • Condon, J. R., Knight, M. and Day, J. L. 1973. Glucagon therapy in acute pancreatitis. Brit. J. Surg., 60, 509.

    Article  PubMed  CAS  Google Scholar 

  • Dyck, W. P., Rudick, J., Hoexter, B. and Janowitz, H. D. 1969. Influence of glucagon on pancreatic exocrine secretion. Gastroenterology, 56, 531.

    PubMed  CAS  Google Scholar 

  • Dyck, W. P., Texter, E. C., Lasater, J. M. and Hightower, N. C. 1970. Influence of glucagon on pancreatic exocrine secretion in man. Gastroenterology, 58, 532.

    PubMed  CAS  Google Scholar 

  • Erlanger, B. F., Kokowsky, N. and Cohen, W. 1961. The preparation and properties of two new chromogenic substrates of trypsin. Arch. Biochem., 95, 271.

    Article  PubMed  CAS  Google Scholar 

  • Hubel, K. A. 1972. Secretin: A long progress note. Gastroenterology, 62, 318.

    PubMed  CAS  Google Scholar 

  • Knight, M. J., Condon, J. R. and Smith, R. 1971. Possible use of glucagon in the treatment of pancreatitis. Brit. med. J., ii, 440.

    Article  Google Scholar 

  • Mutt, V. and Jorpes, E. 1971. Hormonal Polypeptides of the Upper Intestine. Biochem. J., 125, 57p.

  • Nakajima, S. and Magee, D. F. 1970. Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously. Canad. J. Physiol. Pharmacol., 48, 299.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Surgery and of Medicine and Therapeutics, Woodview University College, Dublin 4

    J. J. Murphy & K. F. McGeeney

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  1. J. J. Murphy
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  2. K. F. McGeeney
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Murphy, J.J., McGeeney, K.F. The effects of glucagon on the exocrine secretion of the perfused canine pancreas. Ir J Med Sci 143, 37–41 (1974). https://doi.org/10.1007/BF03004739

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  • DOI: https://doi.org/10.1007/BF03004739

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