Summary and Conclusions
Mixtures of several analgesic and neuroleptic drugs were devised and used in sufficient dosage to provide smooth anaesthesia in dogs. The response of the cardiorespiratory system, metabolic reactions, and postanaesthetic recovery were compared from recordings of the vital signs, blood analyses, and direct observation. These data show that the mixtures of anileridine-thiopental (1:10), fentanyl-droperidol (1:50), fentanyl-thiopental (1:1000), meperidine-thiopental (1:4), pentazocine-thiopental (1:33), and methotrimeprazine-thiopental (1:40) provide satisfactory anaesthetic conditions when used along with the inhalation of nitrous oxide and oxygen, and pulmonary ventilation is controlled during the period of anaesthesia. The thiopental-d’tubocurarine mixture would have been included if it had not caused severe post-anaesthetic respiratory depression. It is suggested that similar conditions may be reproduced clinically with all of these mixtures, but there are two major disadvantages to using such an anaesthetic technique: controllability is difficult to maintain and delayed reactions may be highly undesirable.
Résumé
On a utilisé des mélanges de plusieurs médicaments analgésiques et neuroleptiques à des doses suffisantes pour produire une anesthésie légère chez des chiens. Les effets sur le système cardio-respiratoire, les réactions métaboliques et l’évolution postanesthésique ont été comparés d’après les tracés des signes vitaux, les analyses de sang et l’observation directe. Ces données montrent que les mélanges de anilérédine-thiopental (1:10), fentanyl-dropéridol (1:50), fentanyl-thiopental (1:1000), mépéridine-thiopental (1:4), pentazocine-thiopental (1:33), méthotriméprazine-thiopental (1:40) procurent des conditions anesthésiques satisfaisantes lorsqu’ils sont combinés à une inhalation de protoxyde d’azote et d’oxygène, et que la ventilation est contrôlée durant l’anesthésie. Nous aurions ajouté le mélange thiopental-d-tubocurarine, mais il produit une grave dépression respiratoire postanesthésique. On est d’avis que tous ces mélanges peuvent produire cliniquement de telles conditions, mais que cette technique d’anesthésie présente deux inconvénients sérieux: il est difficile de contrôler la ventilation et il peut se produire des réactions tardives indésirables.
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Dobkin, A.B., Lee, P.K.Y. & Byles, P.H. Neuroleftanalgesics: 2. Laboratory evaluation of combination of analgesics and neuroleptics with nitrous oxide. Can. Anaes. Soc. J. 12, 39–66 (1965). https://doi.org/10.1007/BF03004077
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DOI: https://doi.org/10.1007/BF03004077