Skip to main content
SpringerLink
Log in

Studies on the control of gastric secretion

I. Drugs acting on the autonomic-sympathetic system. II. Drugs acting as central emetics

  • Published:
The American Journal of Digestive Diseases

Summary

In the attempt to diminish the acid gastric secretion by the use of centrally acting emetics, we studied apomorphine, apocodeine, emetine, and quinine. With subemetic doses we were able to decrease the total acid output over the period of observation. However, in order to decrease the height of titratable acidity emetic doses had to be used. These drugs, therefore, are of no practical value in clinical use for diminishing the concentration of the acid secreted by the stomach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Keeton, R. W., Luckhardt, A. B. and Koch, F. C.:Am. J. Physiol., Vol. 51, p. 469, 1920.

    CAS  Google Scholar 

  2. Gray, John:Am. J. Physiol. In press.

  3. Porter, R. T.:Proc. Soc. Exper. Biol. and Med., Vol. 29, p. 504, 1932.

    CAS  Google Scholar 

  4. Klumpp and Bowie, M. A.:J. Clin. Invest., 12:1, Jan., 1933.

    Article  PubMed  CAS  Google Scholar 

  5. Polland, W. S.:J. Clin. Invest., Vol. 9, p. 319, 1930.

    Article  PubMed  CAS  Google Scholar 

  6. Kalk, H. and Siebert, P.:Arch. f. Verdauungskr., 40:313, 1927.

    CAS  Google Scholar 

  7. Keefer, C. S. and Bloomfield, A. L.:Arch. Int. Med., 38, p. 303, 1926.

    CAS  Google Scholar 

  8. Rehfuss, M.:Trans. Am. Gast. Ass’n, 1918.

  9. Winkelstein, A.:Trans. Am. Gast. Ass’n, p. 212, 1933.

  10. Klein, Eugene:Arch. Surg., 26:246, Feb., 1933.

    CAS  Google Scholar 

  11. Roberts, W. M.:Quart. J. Med., 19:74, Oct., 1925.

    CAS  Google Scholar 

  12. Lockwood, B. C. and Chamberlin, H. G.:Arch. Int. Med., 30:806, Dec., 1922.

    CAS  Google Scholar 

  13. Riegel, F.:Ztschr. f. klin. Med., 37:381, 1899 (quoted by Keefer and Bloomfield (5)).

    Google Scholar 

  14. Bergmann:Münch. Med. Woch., LX, 169, 1913 (quoted by W. M. Roberts (9)).

    Google Scholar 

  15. Mathieu: Pathologie Gastro-Intestinale, Paris, IV, 74, 1914 (qouted by W. M. Roberts (9)).

    Google Scholar 

  16. Schmidt:J. A. M. A., LXII, 432, 1914.

    Google Scholar 

  17. Chiari: Therap. Monats., Berlin, XXIX, 202, 1915 (quoted by W. M. Roberts (9)).

    Google Scholar 

  18. Moore and Kilroe:Proc. Roy. Soc. Med., London, IV, 2, Med. Sect. 23–24, 1910–11.

    Google Scholar 

  19. Bennett, T. J.:Guy’s Hospital Report, 71:54, 1921.

    Google Scholar 

  20. Loeper, M. and Fau, R.:C. R. Soc. Biol., Paris, 113, 981, 1933.

    Google Scholar 

  21. Rall, T.:Ztschr. f. d. ges. exper. Med., 52:752, 1926.

    Article  Google Scholar 

  22. Schiff, Aruthr:Arch. f. Verdauungskr., 6:107, 1900.

    Article  Google Scholar 

  23. Kellerman, Emil:Arch. f. Verdauungskr., 45:67, 1925.

    Google Scholar 

  24. Hernando, T.:Presse Medicale, 31:797, Sept. 19, 1923.

    Google Scholar 

  25. Bastedo, W. A.:J. A. M. A., Vol. 106, No. 2, p. 85, Jan. 11, 1936.

    CAS  Google Scholar 

  26. Palmer, W. L.:J. A. M. A., 101, p. 1604, 1933.

    Google Scholar 

  27. Crohn, B. B.:Am. J. M. Sc., 155:801, June, 1918.

    Google Scholar 

  28. Volborth, G. W. and Kudriawzeff, N. N.:Am. J. Physiol., LXXXI, 154.

  29. Baxter, S. G.:Am. J. Dig. Dis. and Nutrit., Vol. 1, p. 36 and p. 40, 1934.

    Google Scholar 

  30. Bickel, A.:Ergeb. d. Physiol., XXIV, 228, 1925 (quoted by Baxter (15)).

    Google Scholar 

  31. Unpublished.

  32. Rothlin, E.: Commun. to Internat. Physiol. Congress, Paris, 1920 (quoted by Baxter (15)).Baxter, S. G.:

    Google Scholar 

  33. Vineberg, A. M.:Am. J. Physiol., XCVII, 363, 1931.

    Google Scholar 

  34. Sollman, Torald: A Manual of Pharmacology. W. B. Saunders Co., Philadelphia.

  35. Klocman, L.:Zeit. f. Physiol. Chem., 80, 17, 1912.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chicago, Illinois

    A. J. Atkinson M.S., M.D. & A. C. Ivy Ph.D., M.D.

Authors
  1. A. J. Atkinson M.S., M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. C. Ivy Ph.D., M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Part of the expense of this investigation was defrayed by contribution from the E. L. Dawes Fund.

From the Departments of Medicine and Physiology and Pharmacology, Northwestern University Medical School, Chicago.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Atkinson, A.J., Ivy, A.C. Studies on the control of gastric secretion. American Journal of Digestive Diseases and Nutrition 4, 811–816 (1937). https://doi.org/10.1007/BF03003045

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03003045

Keywords

Search

Navigation