Skip to main content
SpringerLink
Log in

Comparison of effectiveness of various antacids on gastric acidity

  • Published:
The American Journal of Digestive Diseases

Summary and Conclusions

(1) The effectiveness of various antacids in reducing the acidity in 28 human subjects is reported. No demonstrable difference is apparent between the antacids tested.

(2) Differences in clinical results following the therapeutic use of the above antacids may be on the basis of factors other than acid neutralization.

(3) Enterogastrone and Viodenum both increased the total volume of the gastric secretion in the Histamine stimulated stomach.

(4) Several uncontrolled variables and limitations of the method are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Goldstein, H. I.: The Use of Magnesium Trisilicate, Colloidal Kaolin, and Aluminum Hydroxide in Antacid Gastric Therapy. J. Int. Coll. Surg.2:379, 1939.

    Google Scholar 

  2. Goldstein, H. I.: Ulcer and Cancer of the Stomach in the Middle Ages, J. Internat. Coll. Surg.6:482, 1943.

    Google Scholar 

  3. Palmer, W. L.: The Value of Acid Neutralization in the Treatment of Gastric and Duodenal Ulcers, Arch. Int. Med.46: 165, 1930.

    CAS  Google Scholar 

  4. Bloomfield, A. L. and Keefer, C. S.: A Method for the Continuous Quantitative Estimation of Gastric Secretion and Discharge in Man, Arch. Int. Med.37:819, 1926.

    Google Scholar 

  5. Littman, A. and Ivy, A. C.: The Study of Gastric Acidity in Man, Methods in Medical Research, Vol. I, No. 1, in Press.

  6. Kammerling, Erwin W. and Steigmann, F.: Gastric Secretory Studies with a Mucin Antacid Mixture, Am. J. Dig. Dis.14:381, 1947.

    Article  PubMed  CAS  Google Scholar 

  7. Hardt, L. L. and Brodt, L.: Aluminum Hydroxide and Magnesium Trisilicate Plus Mucin in the Treatment of Peptic Ulcer, Arch. Surg.55:584, 1947.

    CAS  Google Scholar 

  8. Meyer, J., Seidman, E. and Necheles, H.: The Treatment of Peptic Ulcer with Powdered Okra, Ill. Med. J.64:339, 1933.

    Google Scholar 

  9. Kraemer, M. and Lehman, D. J. Jr.: Treatment of Peptic Ulcer with Anion Exchange Resins, Gastroenterology8:208, Feb. 1947.

    Google Scholar 

  10. Greengard, H., Atkinson, A. J., Grossman, M. I., and Ivy, A. C.: The Effectiveness of Parenterally Administered “Enterogastrone” in the Prophylaxis of Recurrences of Experimental and Clinical Peptic Ulcer, Gastroenterology7:625, 1946.

    CAS  Google Scholar 

  11. Alvarez, W. C. Vanzant and Osterberg: Daily Variation in the Concentration of Acid and Pepsin in the Gastric Juice of Three Persons Observed for Two Months, Am. J. Dig. Dis.3:162, 1936–37.

    CAS  Google Scholar 

  12. Schlesinger: Personal communication.

  13. Littman: Personal communication.

Download references

Author information

Authors and Affiliations

  1. Chicago, Ill.

    S. Krasnow M. D., F. Steigmann M. D. & L. L. Hardt M. D.

Authors
  1. S. Krasnow M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Steigmann M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. L. Hardt M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The Hektoen Institute for Medical Research, the Department of Internal Medicine and the Gastro-Intestinal Clinic of Cook County Hospital, the Department of Internal Medicine, University of Illinois, College of Medicine and the Stritch School of Medicine, Loyola University, Chicago, Illinois.

Aided by a grant from the Research Division of the Harrower Laboratories, Inc., Jersey City, New Jersey.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krasnow, S., Steigmann, F. & Hardt, L.L. Comparison of effectiveness of various antacids on gastric acidity. Amer. Jour. Dig. Dis. 17, 242–246 (1950). https://doi.org/10.1007/BF03002596

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03002596

Keywords

Search

Navigation