Summary and Conclusions
Six healthy adult female volunteers were used in the quantitative assessment of their respiratory responses following intravenous administration of meperidine and diazepam. A modified rebreathing CO2-challenge technique of Eckenhoffet al., 5 previously reported,6 was used for this purpose. The CO2 stimulus response curves obtained confirmed the respiratory depressant response following the use of 0.5 mg./kg. meperidine. Diazepam, at dose levels up to 0.066 mg./kg., produced no statistically significant respiratory response to carbon dioxide detectable by this method(p < 0.025).
Résumé
Six adultes volontaires du sexe féminin et en bonne santé ont servi à l’évaluation quantitative des réactions respiratoires à la suite d’injection intraveineuse de mépéridine et de diazepam. On a utilisé à cet effet une technique modifiée de Eckenhoff et coll., décrite antérieurement.
La courbe des réponses obtenues par la stimulation du CO2 a confirmé que l’usage de 0.5 mg./kg. de mépéridine produissait une dépression respiratoire. Le diazepam, à la dose de 0.066 mg./kg., n’a pas produit de réponse de valeur statistique a la stimulation du CO2 en employant cette méthode (p < 0.025).
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Steen, S.N., Weitzner, S.W., Amaha, K. et al. The effect of diazepam on the respiratory response to carbon dioxide. Can. Anaes. Soc. J. 13, 374–377 (1966). https://doi.org/10.1007/BF03002179
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DOI: https://doi.org/10.1007/BF03002179