Skip to main content
Log in

Pathogenesis of acute infectious hepatitis

  • Published:
The American Journal of Digestive Diseases

Conclusion

to conclude, acute infectious hepatitis may be viewed as a generalized infection of virus nature which attacks the reticulo-endothelial system — spleen, lymph nodes, bone marrow and liver. In cases such as in undernourished soldiers in whom the liver has been depleted of its protein and glycogen stores, there results the characteristic pathologic changes in the liver and associated symptomatology of this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Iversen, P., and Roholm, K.: On Aspiration Biopsy of the Liver, With Remarks on Its Diagnostic Significance. Acte Med. Scandinav., 102:1, 1939.

    Google Scholar 

  2. Roholm, K., and Iversen, P.: Changes in the Liver in Acute Epidemic Hepatitis (Catarrhal Jaundice) Based on 38 Aspiration Biopsies. Acta Path. et Microbiol, Scandinav, 16:427, 1939.

    Google Scholar 

  3. Roholm, K., and Krarup, N. B.: Die Histopathologie der Leber Bei Sogennanten Salvarsanikterus Mittels Aspirationbiopsie Untersucht. Arch. f. Dermat. u. Syph., 181:521, 1940.

    Article  Google Scholar 

  4. Dible, J. H., McMichael, J., and Sherlock, S. P. V.: Pathology of Acute Hepatitis (Aspiration Biopsy Studies of Epidemic Arsenotherapy and Serum Jaundice). Lancet, 2:402 (Oct. 2), 1943.

    Article  Google Scholar 

  5. Goodman, J. I.: Use of percussion in Acute Infectious Hepatitis. Am. J. Dig. Dis., 13:294, 1946.

    Google Scholar 

  6. Jossem, J., Harefuah (Journ. Palestine Jewish Med. Assoc.) 19:25, 1940 (cited by Cameron, J. D. S. Quart. J. Med. 12:139, 1943: Infective Hepatitis).

    Google Scholar 

  7. Wayburn, E.: Epidemic Infectious Hepatitis, Gastroenterology, 4:147, 1945.

    Google Scholar 

  8. Lucke, B.: The Pathology of Fatal Epidemic Hepatitis. Am. J. Path., 20:471, 1944.

    PubMed  Google Scholar 

  9. Landolt, R. F.: Lymphatic Reaction in Hepatitis Epidemica, Schweiz. med. Wchnschr., Basel 72:1346 (Dec. 5), 1942, abstr. J. A. M. A., 123:176 (Sept. 18), 1943.

    Google Scholar 

  10. Finks, R. M., and Blumberg, R. W.: Epidemic Hepatitis With and Without Jaundice: Some Clinical Studies on Two Hundred and Fifty-Five Patients among Troops in a Combat Zone. Arch. Int. Med., 76:102, 1945.

    Google Scholar 

  11. Barker, M. H., Capps, R. B., and Allen, F. W.: Acute Infectious Hepatitis in the Mediterranean Theater (including acute hepatitis without jaundice). J. A. M. A., 128:997, Aug., 1945; Chronic Hepatitis in the Mediterranean Theater: A New Clinical Syndrome, J. A. M. A., 129:653 (Nov. 3), 1945.

    Google Scholar 

  12. Fox, J. P., Manso, C., Penna, H. A., and Para, M.: Observations on the Occurrence of Icterus in Brazil Following Vaccination Against Yellow Fever. Am. J. Hyg., 36:68, 1942.

    Google Scholar 

  13. Jones, C. M., and Minot, G. R.: Infectious (Catarrhal) Jaundice. An Attempt to Establish a Clinical Entity: Observations on the Excretion and Retention of the Bile Pigments, and on the Blood. Boston M. & S. J., 189:531, 1923.

    Google Scholar 

  14. Snell, A. M., Wood, D. A., and Meienberg, L. J.: Infectious Hepatitis With Especial Reference to Its Occurrence in Wounded Men. Gastroenterology, 5:241, 1945.

    Google Scholar 

  15. Sapero, J. J., and Butler, F. A.: Highlights on Epidemic Diseases Occurring in Military Forces (in the early phases of the war in the South Pacific). J. A. M. A., 127:502 (March 3), 1945.

    Google Scholar 

  16. Dietrich, S.: So-Called Catarrhal Icterus and Epidemic Hepatitis. Deutsche med. Wchnschr., 68:5 (Jan. 2), 1942, abstr. J. A. M. A., 123:662 (Nov. 6), 1943.

    Article  Google Scholar 

  17. Bent, M. J., Turner, E. L., Holloway, G. D., and Cuff, J. R.: Nutritional Deficiency as an Etiological Factor in Icterus Accompanying Pneumonia in the Negro: II. Value of Brewer’s Yeast in Preventing Icterus in Pneumonia. South. M. J., 38:730 (Nov.), 1945.

    Google Scholar 

  18. Gyorgy, P., and Goldblatt, H.: Hepatic Injury on Nutritional Basis in Rats. J. Exper. Med., 70:185, 1939; Observations on the Conditions of Dietary Hepatic Injury (Necrosis, Cirrhosis) in Rats. J. Exper. Med., 75:355, 1942.

    Article  CAS  Google Scholar 

  19. Rich, A. R., and Hamilton, J. D.: The Experimental Production of Cirrhosis of the Liver by Means of a Deficient Diet. Bull. Johns Hopkins Hosp., 66:185, 1940.

    CAS  Google Scholar 

  20. Gyorgy, P.: Experimental Hepatic Injury. Am. J. Clin. Path., 14:67 (Feb.), 1944.

    CAS  Google Scholar 

  21. Himsworth, H. P., and Glynn, L. E.: Massive Hepatic Necrosis and Diffuse Hepatic Fibrosis (Acute Yellow Atrophy and Portal Cirrhosis): Their Production by Means of Diet. Clin. Sc., 5:93, 1944.

    CAS  Google Scholar 

  22. Davis, N. C., and Whipple, G. H.: The Influence of Fasting and Various Diets on the Liver Injury Effected by Chloroform Anesthesia. Arch. Int. Med., 23:612, 1919.

    CAS  Google Scholar 

  23. Elman, R., and Heifetz, C. J.: Experimental Hypoalbuminemia: Its Effect on Morphology, Function and Protein and Water Content of Liver. J. Exper. Med. 73:417 (March), 1941.

    Article  CAS  Google Scholar 

  24. Addis, T., Poo, L. J., and Lew, W.: The Quantities of Protein Lost by the Various Organs and Tissues of the Body During a Fast. J. Biol. Chem., 115:111, 1936.

    CAS  Google Scholar 

  25. Messinger, W. J., and Hawkins, W. B.: Arsphenamine Liver Injury Modified by Diet. Protein and Carbohydrate Protective, But Fat Injurious. Mm. J. M. Cc., 199:216, 1940.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goodman, J.I. Pathogenesis of acute infectious hepatitis. Jour. D. D. 14, 26–29 (1947). https://doi.org/10.1007/BF03001258

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03001258

Keywords

Navigation