Conclusion
to conclude, acute infectious hepatitis may be viewed as a generalized infection of virus nature which attacks the reticulo-endothelial system — spleen, lymph nodes, bone marrow and liver. In cases such as in undernourished soldiers in whom the liver has been depleted of its protein and glycogen stores, there results the characteristic pathologic changes in the liver and associated symptomatology of this disease.
Similar content being viewed by others
References
Iversen, P., and Roholm, K.: On Aspiration Biopsy of the Liver, With Remarks on Its Diagnostic Significance. Acte Med. Scandinav., 102:1, 1939.
Roholm, K., and Iversen, P.: Changes in the Liver in Acute Epidemic Hepatitis (Catarrhal Jaundice) Based on 38 Aspiration Biopsies. Acta Path. et Microbiol, Scandinav, 16:427, 1939.
Roholm, K., and Krarup, N. B.: Die Histopathologie der Leber Bei Sogennanten Salvarsanikterus Mittels Aspirationbiopsie Untersucht. Arch. f. Dermat. u. Syph., 181:521, 1940.
Dible, J. H., McMichael, J., and Sherlock, S. P. V.: Pathology of Acute Hepatitis (Aspiration Biopsy Studies of Epidemic Arsenotherapy and Serum Jaundice). Lancet, 2:402 (Oct. 2), 1943.
Goodman, J. I.: Use of percussion in Acute Infectious Hepatitis. Am. J. Dig. Dis., 13:294, 1946.
Jossem, J., Harefuah (Journ. Palestine Jewish Med. Assoc.) 19:25, 1940 (cited by Cameron, J. D. S. Quart. J. Med. 12:139, 1943: Infective Hepatitis).
Wayburn, E.: Epidemic Infectious Hepatitis, Gastroenterology, 4:147, 1945.
Lucke, B.: The Pathology of Fatal Epidemic Hepatitis. Am. J. Path., 20:471, 1944.
Landolt, R. F.: Lymphatic Reaction in Hepatitis Epidemica, Schweiz. med. Wchnschr., Basel 72:1346 (Dec. 5), 1942, abstr. J. A. M. A., 123:176 (Sept. 18), 1943.
Finks, R. M., and Blumberg, R. W.: Epidemic Hepatitis With and Without Jaundice: Some Clinical Studies on Two Hundred and Fifty-Five Patients among Troops in a Combat Zone. Arch. Int. Med., 76:102, 1945.
Barker, M. H., Capps, R. B., and Allen, F. W.: Acute Infectious Hepatitis in the Mediterranean Theater (including acute hepatitis without jaundice). J. A. M. A., 128:997, Aug., 1945; Chronic Hepatitis in the Mediterranean Theater: A New Clinical Syndrome, J. A. M. A., 129:653 (Nov. 3), 1945.
Fox, J. P., Manso, C., Penna, H. A., and Para, M.: Observations on the Occurrence of Icterus in Brazil Following Vaccination Against Yellow Fever. Am. J. Hyg., 36:68, 1942.
Jones, C. M., and Minot, G. R.: Infectious (Catarrhal) Jaundice. An Attempt to Establish a Clinical Entity: Observations on the Excretion and Retention of the Bile Pigments, and on the Blood. Boston M. & S. J., 189:531, 1923.
Snell, A. M., Wood, D. A., and Meienberg, L. J.: Infectious Hepatitis With Especial Reference to Its Occurrence in Wounded Men. Gastroenterology, 5:241, 1945.
Sapero, J. J., and Butler, F. A.: Highlights on Epidemic Diseases Occurring in Military Forces (in the early phases of the war in the South Pacific). J. A. M. A., 127:502 (March 3), 1945.
Dietrich, S.: So-Called Catarrhal Icterus and Epidemic Hepatitis. Deutsche med. Wchnschr., 68:5 (Jan. 2), 1942, abstr. J. A. M. A., 123:662 (Nov. 6), 1943.
Bent, M. J., Turner, E. L., Holloway, G. D., and Cuff, J. R.: Nutritional Deficiency as an Etiological Factor in Icterus Accompanying Pneumonia in the Negro: II. Value of Brewer’s Yeast in Preventing Icterus in Pneumonia. South. M. J., 38:730 (Nov.), 1945.
Gyorgy, P., and Goldblatt, H.: Hepatic Injury on Nutritional Basis in Rats. J. Exper. Med., 70:185, 1939; Observations on the Conditions of Dietary Hepatic Injury (Necrosis, Cirrhosis) in Rats. J. Exper. Med., 75:355, 1942.
Rich, A. R., and Hamilton, J. D.: The Experimental Production of Cirrhosis of the Liver by Means of a Deficient Diet. Bull. Johns Hopkins Hosp., 66:185, 1940.
Gyorgy, P.: Experimental Hepatic Injury. Am. J. Clin. Path., 14:67 (Feb.), 1944.
Himsworth, H. P., and Glynn, L. E.: Massive Hepatic Necrosis and Diffuse Hepatic Fibrosis (Acute Yellow Atrophy and Portal Cirrhosis): Their Production by Means of Diet. Clin. Sc., 5:93, 1944.
Davis, N. C., and Whipple, G. H.: The Influence of Fasting and Various Diets on the Liver Injury Effected by Chloroform Anesthesia. Arch. Int. Med., 23:612, 1919.
Elman, R., and Heifetz, C. J.: Experimental Hypoalbuminemia: Its Effect on Morphology, Function and Protein and Water Content of Liver. J. Exper. Med. 73:417 (March), 1941.
Addis, T., Poo, L. J., and Lew, W.: The Quantities of Protein Lost by the Various Organs and Tissues of the Body During a Fast. J. Biol. Chem., 115:111, 1936.
Messinger, W. J., and Hawkins, W. B.: Arsphenamine Liver Injury Modified by Diet. Protein and Carbohydrate Protective, But Fat Injurious. Mm. J. M. Cc., 199:216, 1940.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goodman, J.I. Pathogenesis of acute infectious hepatitis. Jour. D. D. 14, 26–29 (1947). https://doi.org/10.1007/BF03001258
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03001258