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Nocturnal and diurnal variations in the acidity of the spontaneous secretion of gastric juice

  • Experimental Physiology
  • Published:
The American Journal of Digestive Diseases

Conclusions

1. The normal fasting stomach secretes continuously, day and night.

2. The fasting gastric contents may exceed in acidity that accumulated in response to test meal stimulation.

3. The acidity of the fasting secretion rises and falls intermittently, in the absence of all intentional stimulation.

4. The mean acidity of the night secretion of the fasting stomach exceeds that of the day secretion.

5. A secretory-motor relationship is postulated to explain the fluctuation of the acid values of the aspirated gastric contents though there is no quantitative evidence to exclude extra-gastric contamination as the modus operandi.

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Author information

Authors and Affiliations

  1. Madison, Wisconsin

    Frances A. Hellebrandt M.D., Rubye H. Tepper M.S., Helen Grant M.S. & Ruth Catherwood M.S.

Authors
  1. Frances A. Hellebrandt M.D.
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  2. Rubye H. Tepper M.S.
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  3. Helen Grant M.S.
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  4. Ruth Catherwood M.S.
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Additional information

From the School of Medicine, University of Wisconsin, Department of Physiology. Supported in part by funds from the Wisconsin Alumni Research Foundation.

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Hellebrandt, F.A., Tepper, R.H., Grant, H. et al. Nocturnal and diurnal variations in the acidity of the spontaneous secretion of gastric juice. American Journal of Digestive Diseases and Nutrition 3, 477–481 (1936). https://doi.org/10.1007/BF03000734

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  • DOI: https://doi.org/10.1007/BF03000734

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