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Failure to develop a conditional reflex by stimulation of the cephalad portion of the severed vagosympathetic trunk: Its significance in terms of the central connections of the vagus

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Abstract

Stimulation of the central stump of either vagosympathetic trunk in the dog, the contralateral nerve remaining intact, regularly provoked deep respiratory movements with forceful expiration, followed by a period of apnea, and a fall in blood pressure, systolic and diastolic, of 20–60 mm/Hg. Stimulation of the cephalad portion of the left nerve provoked brief acceleration of heart rate during the period of hyperventilation, followed by bradycardia; when the stimulus was applied to the central stump of the right nerve heart rate remained relatively unchanged. When a 12-second tone as a conditional stimulus (CS) was reinforced during its last six seconds with such stimulation of the vagosympathetic trunk as an unconditional stimulus (US), despite the striking visceromotor responses elicited by the US, no conditional reflex was established even after more than 3,400 trials in 16 dogs (34–781 trials per animal).

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References

  • Adrian, E. D.: Afferent impulses in the vagus and their effect on respiration.J. Physiol.,79: 332, 1933.

    PubMed  Google Scholar 

  • Agostoni, E., Chinnock, J. E., Daly, M.deB., and Murray, J. G.: Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat.J. Physiol.,135: 182, 1957.

    PubMed  Google Scholar 

  • Bailey, P., and Bremer, F.: A sensory cortical representation of the vagus nerve.J. Neurophysiol.,1: 404, 1938.

    Google Scholar 

  • Bert, P.:Leçons sur la Physiologie Compareé de la Respiration. Balliere, Paris, 1879.

    Google Scholar 

  • Bezold, A. von, and Hirt, L.: Untersuch.Physiol. Lab. Würzburg,1: 95, 1867.

    Google Scholar 

  • Birykov, D. A., Komeva, E. A., Shlyafer, T. P., and Yakoleva, M. L:. Phylogenetic and ontogenetic patterns in development of reflex regulation of cardiac activity and respiration in animals.Fed. Proc,22: T-80, 1963.

    Google Scholar 

  • Bonhoeffer, K., Kramer, K., and Muehl, N.: Ueber die Zuordnung pressorischer and depressorischer Kreislaufreflexe zu einzelnen Fasergruppen im Halsvagus des Hundes.Arch. Ges. Physiol.,267: 265, 1958.

    Article  Google Scholar 

  • Brick, I.: Circulatory responses to immersing the face in water.J. App. Physiol.,17: 33, 1966.

    Google Scholar 

  • Bykov, K. M.: The Cerebral Cortex and Internal Organs. Translation by W. H. Gantt. New York, Chemical Publishing Co., 1957.

    Google Scholar 

  • Bykov, K. M., and Alexijew-Berkman, I. A.: Die Ausbildung bedingter Reflexe auf die Harnausscheidung.Arch. Ges. Physiol,224: 710, 1930.

    Article  Google Scholar 

  • Caralesu, F. R., and Pearce, J. W.: Electrical activity of efferent vagal fibers and dorsal nucleus of the vagus during reflex bradycardia in the cat.J. Physiol,176: 228, 1964a.

    Google Scholar 

  • Caralesu, F. R., and Pearce, J. W.: Effects on heart rate of electrical stimulation of medullary vagal structures in the cat.J. Physiol,176: 241, 1964b.

    Google Scholar 

  • Cheringovskii, V. N.: Morphophysiologic architecture of subcortical and cortical projections of afferent vagus nerve fibers.Fed. Proc,24: (translation supplement) 668, 1965.

    Google Scholar 

  • Corson, S. A.: Conditioning of water and electrolyte excretion.Res. Publ. Ass. Res. New. Ment. Dis.,43: 140, 1966.

    Google Scholar 

  • Corson, S. A.: Endocrines and the central nervous system.Res. Publ. Ass. Res. Nerv. Ment. Dis.,43: 140, 1966.

    PubMed  Google Scholar 

  • Cottle, M. K.: Degeneration studies of the primary afferents of IXth and Xth cranial nerves.J. Comp. Neurol.,122: 329, 1964.

    Article  PubMed  Google Scholar 

  • Daggett, W. M., Nugent, G. C., Carr, P. W., Powers, P. C., and Harada, Y.: Influence of vagal stimulation on ventricular contractility, O2 consumption and coronary flow.Am. J. Physiol.,212: 8, 1967.

    PubMed  Google Scholar 

  • Dawes, G. S.: Studies on veratrum alkaloids: Receptor areas in coronary arteries and elsewhere as revealed by the use of veratridine.J. Pharmacol. Exp. Ther.,89: 325, 1947.

    PubMed  Google Scholar 

  • Dedashev, Ya. P.: Exteroceptive and interoceptive conditioned reflex influences on the motor activity of the reticulum and rumen in sheep.Fiziol. Zh. SSSR Sechenov,45: 1259, 1962. (Quoted by Razran, R. L.:Psychol. Rev., 68:81.)

    Google Scholar 

  • DeGeest, H., Levy, M. N., Zeeske, H., and Lipman, R. I.: Depression of ventricular contractility by stimulation of the vagus nerves.Circ. Res.,17: 222, 1965.

    PubMed  Google Scholar 

  • Dell, P., and Olson, R.: Projections thalamiques, corticales et cerebelleuses des afferences viscerales vagales.Compt. Rend. Soc. Biol.,145: 1084, 1951.

    Google Scholar 

  • Dell, P., and Olson, R.: Idem. Projections “secondaires” mesencephaliques, diencephaliques et amygdaliennes des afference viscerales vagales,Compt. Rend. Soc. Biol,145: 1088, 1951.

    Google Scholar 

  • Feley, J. O., and DuBois, F. S.: Quantitative studies of the vagus nerve in the cat: (1) Ratio of sensory to motor fibers.J. Comp. Neurol. 67: 49, 1937.

    Article  Google Scholar 

  • Gantt, W. H.: Pharmacological agents in study of higher nervous activity.Dis. Nerv. Syst.,18: 1, 1957.

    Google Scholar 

  • Getz, B., and Sernes, T.: The localization within the dorsal motor vagal nucleus. An experimental investigation.J. Comp. Neurol.,90: 95, 1949.

    Article  PubMed  Google Scholar 

  • Gssell, R. A.: Cardiodynamics in heart block as affected by auricular systole, auricular fibrillation and stimulation of the vagus nerve.Am. J. Physiol.,40: 267, 1916.

    Google Scholar 

  • Gunn, C. G., Sevelius, G., Puiggar, M. J., and Myers, F. K.: Vagal cardiomotor mechanisms in the hindbrain of the dog and cat.Am. J. Physiol.,214: 258, 1968.

    PubMed  Google Scholar 

  • Heinbecker, P., and O’Leary, J.: The mammalian vagus nerve-a functional and histological study.Am. J. Physiol.,106: 623, 1933.

    Google Scholar 

  • Hering, E., and Breuer, J.: Die Selbststeuerung der Atmung durch den Vagus.Setzungsb. d.k. Akad. d. Wissenschaft (Wien),57: 672; 58:909, 1868.

    Google Scholar 

  • Hering, H. E.: Der Karotisdruckversuch.Munchnen Med. Wschr.,70: 1287, 1923.

    Google Scholar 

  • Heymans, C., Bouckaert, J. F., and Regniers, P.: Le sinus carotidien et la zone homologue cardio-aortique. Paris, Doin & Cie, 1933.

    Google Scholar 

  • Heymans, C., and Neil, E.: Reflexogenic areas of the cardiovascular system. London, Churchill, 1958.

    Google Scholar 

  • Hoffman, H. H., and Kuntz, A.: Vagus nerve components.Anat. Rec,127: 551, 1957.

    Article  PubMed  Google Scholar 

  • James, A. H.: Cardiac syncope after swallowing.Lancet,1: 771, 1958.

    Article  PubMed  Google Scholar 

  • Jarisch, A., and Zotterman, Y.: Depressor reflexes from the heart.Acta Physiol Scand.,16: 31, 1948.

    Article  Google Scholar 

  • Jones, J. V.: The afferent pathway of the Bezold reflex: The right vagal branches in cats.Brit. J. Pharmacol,8: 352, 1953.

    PubMed  Google Scholar 

  • Jones, R. L.: Cell fiber ratios in the vagus nerve.J. Comp. Neurol,67: 469, 1937.

    Article  Google Scholar 

  • Kerr, F. W. L.: Function of the dorsal motor nucleus of the vagus.Science,157: 451, 1967.

    Article  PubMed  Google Scholar 

  • Komendantova: Quoted by Bykov, 1957, p. 47.

  • Kopald, H. H., Roth, H. P., Flesher, B., and Pritchard, W. H.: Vagovagal syncope.New Eng. J. Med.,271: 1238, 1964.

    Article  PubMed  Google Scholar 

  • Kosupkin, J. M., and Olmsted, J. M. D.: Slowing of the heart as a conditional reflex in the rabbit.Am. J. Physiol,139: 550, 1943.

    Google Scholar 

  • Lamb, L. E., Dermksian, G., and Samoff, C. A.: Significant cardiac arrhythmias induced by common respiratory maneuvers.Am. J. Cardiol.,2: 563, 1958.

    Article  PubMed  Google Scholar 

  • Levine, S. A.: Oculocardiac reflex.Arch. Int. Med.,15: 758, 1915.

    Google Scholar 

  • Mitchell, G. A. G., and Warwick, R.: The dorsal vagal nucleus.Acta Anat.,25: 31, 1955.

    Article  Google Scholar 

  • Napolitano, L. M., Willman, V. T., Hanlon, C. R., and Cooper, T.: Intrinsic innervation of the heart.Am. J. Physiol,208: 455, 1965.

    PubMed  Google Scholar 

  • Nonindez, J. F.: Studies on the innervation of the heart. I. Distribution of the cardiac nerves with special reference to the identification of the sympathetic and parasympathetic postganglionics.Am. J. Anat.,65: 361, 1939.

    Article  Google Scholar 

  • Oberholzer, R. J. H.: Afferent fibers of cardiovascular and pulmonary origins and their intrabrellar connections.Tohoku J. Exp. Med.,80: 288, 1962.

    Article  Google Scholar 

  • Paintal, A. S.: Conduction velocities of respiratory and cardiovascular afferent fibers in the vagus nerve.J. Physiol.,121: 341, 1953.

    PubMed  Google Scholar 

  • Paintal, A. S.: Vagal afferent fibers.Ergebn. Physiol,52: 74, 1963.

    PubMed  Google Scholar 

  • Perez-Cruet, J., Jude, J. R., and Gantt, W. H.: An attempt to condition extrasystoles using direct myocardial electrical stimulation as an unconditional stimulus.Conditional Reflex,1: 104, 1966.

    Google Scholar 

  • Plumlee, L. A.: Personal communication.

  • Pogrebkova, A. V.: Conditioned reflexes to hypercapnia.Dokl. Akad. Nauk. SSSR,73: 225, 1950. (Quoted by Razran, R. L.:Psychol. Rev., 68:81, 1961.)

    Google Scholar 

  • Pogrebkova, A. V.: Respiratory interoand exteroceptive conditioned reflexes and their interrelationship.Trud. Inst. Fiziol. Pavlova,1: 103, 1952.

    Google Scholar 

  • Richet, C.: De la resistance des canards a l’asphyxie.J. Physiol. Pathol. Gen.,1: 641, 1899.

    Google Scholar 

  • Rudiger, W., and Lindeman, M.: Gallbladder distention and the effects of several drugs on heart rate, respiratory movements and cortical potentials in cats with hypothalamic lesions.Conditional Reflex,2: 113, 1967.

    Google Scholar 

  • Samonina, G. E., and Udel’nov, M. G.: Electrophysiological analysis of activity in cardiac branches of vagus nerves in the course of viscero-cardiac reflexes.Fed. Proc,24: T567, 1965.

    Google Scholar 

  • Sarokhtin, J., Turgel, K. U., and Minut-Sarokhtina, O.:Zh. Fiseol. USSR,17: 207, 1934. Quoted by Kosupkin, J. M. and Olmsted, J. M. D.: Slowing of the heart as a conditioned reflex in the rabbit.Am. J. Physiol., 139:550, 1943.

    Google Scholar 

  • Tcheng, K. T.: Innervation du myocarde et du faisceau de His chez deux mammiferes, le mouton et le chat.Cardiologia,15: 227, 1949.

    Article  Google Scholar 

  • Tcheng, K. T.: Innervation of the dog’s heart.Am. Heart J.,41: 512, 1951.

    Article  PubMed  Google Scholar 

  • Teitelbaum, H. A., Gantt, W. H., and Stone, A.: Cardiac conditional reflexes can be formed to pain not to acetylcholine.J. Nerv. Ment. Dis.,123: 484, 1956.

    Article  PubMed  Google Scholar 

  • Uvnas, B.: Central cardiovascular control. InHandbook of Physiology. Sec. I, vol. 11, 1146. Baltimore, Williams and Wilkins, 1960.

    Google Scholar 

  • Wang, H. H., Blumenthal, M. R., and Wang, S. C.: Effect of efferent vagal stimulation on coronary sinus outflow and cardiac work in the anesthetized dog.Circ. Res.,8: 271, 1960.

    PubMed  Google Scholar 

  • Wang, S. C., and Borson, H. L.: An analysis of the carotid sinus cardiovascular reflex mechanism.Am. J. Physiol,150: 712, 1947.

    PubMed  Google Scholar 

  • Weiss, S., and Ferris, E. B.: Adams-Stokes syndrome with complete heart block of vagovagal reflex origin.Arch. Int. Med.,54: 931, 1934.

    Google Scholar 

  • Whitteridge, D.: Afferent nerve fibers from heart and lungs in the cervical. vagus.J. Physiol,107: 496, 1948.

    PubMed  Google Scholar 

  • Widdecombe, J. G.: Respiratory reflexes from the trachea and bronchi of the cat.J. Physiol,123: 57; 71, 1954.

    Google Scholar 

  • Wolf, S., Schneider, R. A., and Groover, M. E.: Further studies on the circulatory and metabolic alterations of the oyxgen-conserving (diving) reflex in man.Trans. Ass. Amer. Physicians,78: 242, 1965.

    PubMed  Google Scholar 

  • Wolf, S.: The bradycardia of the dive reflex-a possible mechanism of sudden death.Trans. Amer. Clin. Climat. Ass.,76: 192, 1964.

    Google Scholar 

  • Wyss, D. A. M.: Respiratory effects from stimulation of the afferent vagus nerve.J. Neurophysiol,10: 315, 1947.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. The Johns Hopkins University School of Medicine, Baltimore, Maryland

    E. Cowles Andrus, W. Horsley Gantt, L. A. Plumlee & K. Gross

  2. The Pavlovian Laboratory, VA Hospital, Perry Point, Maryland

    W. Horsley Gantt

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  1. E. Cowles Andrus
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  2. W. Horsley Gantt
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  3. L. A. Plumlee
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  4. K. Gross
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Supported by Grant HE-06945 from the National Heart Institute.

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Andrus, E.C., Gantt, W.H., Plumlee, L.A. et al. Failure to develop a conditional reflex by stimulation of the cephalad portion of the severed vagosympathetic trunk: Its significance in terms of the central connections of the vagus. Conditional Reflex 4, 6–19 (1969). https://doi.org/10.1007/BF03000073

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