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The physiological control of gastric acidity

  • Published:
The American Journal of Digestive Diseases

Summary

The physiological control of gastric acidity depends upon the following factors:

  1. 1.

    Strength of the acid secreted.

  2. 2.

    Regurgitation of non-acid secretions from the duodenum.

  3. 3.

    Inhibition of the intragastric chemical phase of acid secretion due to the presence of acid in the stomach and of the intestinal phase of acid secretion due to the presence of acid in the intestine.

  4. 4.

    The intensity of the stimuli arising in the pars pylorica and the degree to which, in a given animal, they influence the intragastric chemical phase of acid secretion.

  5. 5.

    Vagal or cephalic influences.

  6. 6.

    Absorption of water from the gastric contents.

The relative importance and the interrelations of these factors are briefly discussed.

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References

  1. Hollander, Franklin and Cowgill, G. R.:Jour. Biol. Chem., 91:151, April, 1931.

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  2. Hollander, Franklin:Am. Jour. Physiol., 98:551, Nov., 1931.

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  3. Hollander, Franklin:Jour. Biol. Chem., 97:585, Aug., 1932.

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  4. Hollander, Franklin:Jour. Biol. Chem., 104:33, Jan., 1934.

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Author information

Authors and Affiliations

  1. Omaha, Nebraska

    Charles M. Wilhelmj M.D., Rex W. Finegan M.D. & Frederick C. Hill M.D.

Authors
  1. Charles M. Wilhelmj M.D.
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  2. Rex W. Finegan M.D.
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  3. Frederick C. Hill M.D.
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Additional information

Departments of Physiology and Experimental Surgery, Creighton University School of Medicine.

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Wilhelmj, C.M., Finegan, R.W. & Hill, F.C. The physiological control of gastric acidity. American Journal of Digestive Diseases and Nutrition 4, 547–550 (1937). https://doi.org/10.1007/BF02999978

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  • DOI: https://doi.org/10.1007/BF02999978

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