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Human autonomic pharmacology

8. The effect of iontophoresis on the gastric juices with especial reference to acetyl-beta-methyl choline chloride (Mecholyl)

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The American Journal of Digestive Diseases

Conclusions

1. The administration of mecholyl by iontophoresis produces an alkaline mucous gastric juice as effectively as it does when given by subcutaneous injection. Furthermore, the method of iontophoresis with mecholyl for the production of an alkaline juice has distinct advantages over its administration by subcutaneous route, namely, the effects of the drug are not so explosive; the drop in blood pressure is not so sudden or marked; and the period of time of the alkalinity is markedly increased. For these reasons the former method would appear to be the method of choice for its possible therapeutic application in gastric ulcer. The administration of prostigmin before iontophoresis of mecholyl is strongly recommended, since the effects of mecholyl are regularly enhanced. By the use of these two drugs the alkalinity of the gastric juice can be maintained for two hours or longer.

2. Iontophoresis of benzedrine causes a slight increase in the acidity of the gastric juice associated with a rise in blood pressure. These changes are not so marked as when the drug is administered by parenteral route.

3. The administration of histamin by iontophoresis results in a much greater increase in gastric acidity than does benzedrine.

4. The administration of prostigmin by iontophoresis causes no significant changes in the acid level of the gastric juice.

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Authors and Affiliations

  1. Mattapan, Massachusetts

    Julius Loman M.D., Max Rinkel M.D. & Abraham Myerson M.D.

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  1. Julius Loman M.D.
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  2. Max Rinkel M.D.
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  3. Abraham Myerson M.D.
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Additional information

From the Division of Psychiatric Research, Boston Stae Hospital, Mattapan, Mass., aided by grants from the Commonwealth of Massachusetts, the Herbert L. Celler Foundation and the Rockefeller Foundation.

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Loman, J., Rinkel, M. & Myerson, A. Human autonomic pharmacology. American Journal of Digestive Diseases and Nutrition 4, 386–390 (1937). https://doi.org/10.1007/BF02999939

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