Summary
It would seem that histamine performs two functions so far as the presence of pepsin in the stomach is concerned: First, it causes a washing out of the preformed pepsin and, second, it stimulates an actual secretory increase in the function of the parietal cells.
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References
Osterberg, A. E., Vanzant, Frances R. and Alvarez, W. C.: Studies of gastric pepsin. I. Methods of measurement and factors which influence it.Jour. Clin. Invest., 12:551–556, May, 1933.
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Rivers, A.B., Vanzant, F.R. A study of peptic activity by means of the double histamine test. American Journal of Digestive Diseases and Nutrition 4, 304–306 (1937). https://doi.org/10.1007/BF02999923
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DOI: https://doi.org/10.1007/BF02999923