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The chemical nature of the anti-anemic principle

  • Nutrition
  • Published:
The American Journal of Digestive Diseases

Summary

To summarize the work done, all that can be said is that before 1935, most of the sentiment rested with the anti-anemic principle’s being a nitrogenous base while Dakin has since shown us the possibility of a glucosamine peptid perhaps derived from a mucin-like substance.

Further work on the chemical nature of the anti-anemic principle, greatly retarded by the present methods of testing products, will surely go ahead much faster should a more convenient method be developed. In this respect K. Singer has recently suggested the use of rats (36). In addition, after making a complete survey of the literature on the bioassay of anti-anemic material, Jacobson (47) has himself offered a guinea pig technique (48) which proved to be most promising. Crude extracts of fresh human livers assayed by him yielded results that corresponded beautifully with the state of the patient in pernicious anemia. However, his work has not yet been confirmed and some who have tried it deny its usefulness (49).

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Authors and Affiliations

  1. Ann Arbor, Michigan

    Julius Schultz B.S.

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  1. Julius Schultz B.S.
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From the Division of Biologic Chemistry, University of Michigan.

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Schultz, J. The chemical nature of the anti-anemic principle. American Journal of Digestive Diseases and Nutrition 3, 405–412 (1936). https://doi.org/10.1007/BF02999162

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  • DOI: https://doi.org/10.1007/BF02999162

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