Skip to main content
SpringerLink
Log in

Experimental peptic ulcer

The effect of surgical duodenal drainage upon dogs and the value of histidine in preventing ulcer

  • Abdominal Surgery
  • Published:
The American Journal of Digestive Diseases

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Conclusions

1. Surgical duodenal drainage in addition to producing jejunal ulcers causes many other pathological changes in the dog.

  1. (a)

    Marked cachexia develops.

  2. (b)

    Changes in the electrolyte pattern occur, including chiefly a fall in serum protein and serum bicarbonate and a rise in serum chloride.

  3. (c)

    The blood amino nitrogen is variable but tends to be lower after the operation.

  4. (d)

    A marked secondary anemia develops.

  5. (e)

    No increase in gastric acidity in response to a broth meal occurs. A decrease in acidity was found during the last two weeks of life.

2. Six of eleven dogs receiving daily injections of histidine monohydrochloride after surgical duodenal drainage developed ulcers. Five controls not receiving histidine all developed ulcers.

3. The administration of histidine did not influence the other physiological and pathological changes described.

4. The administration of histidine did not affect the amino nitrogen content of the jejunum or antral portion of the stomach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Weiss, A. G., and Aron E.: Role des acides amines dans l’ evolution de l’ulcere experimental.La Presse Medicale, No. 93, Nov. 22, 1933.

  2. Mann, F. C., and Williamson, C. S.: The Experimental Production of Peptic Ulcer.Ann. Surg., 77:409, 1923.

    Article  PubMed  CAS  Google Scholar 

  3. McCann, J. C.: Experimental Peptic Ulcer.Arch. Surg., 19:600, 1929.

    Google Scholar 

  4. Matthews, W. B., and Dragstedt, L. R.: Etiology of Gastric and Duodenal Ulcer; Experimental studies.S. G. O., 55:265, 1932.

    Google Scholar 

  5. Weiss, A. G.: Ulceres chroniques gastro-duodenaux experimentaux crees par la derivation des sues alcalins duodenaux.Strasbourg Med., 90:549, 1930.

    Google Scholar 

  6. Atchley, D. W., and Benedict, E. M.: The Distribution of Electrolytes in Dogs following Ligation of both Ureters.Jour. Biol. Chem., Vol. 73, p. 1, 1927.

    CAS  Google Scholar 

  7. Loeb, R. F., Atchley, D. W., Benedict, E. M., and Leland, J. R.: Electrolyte Balance Studies in Adrenalectomized Dogs with Particular Reference to Excretion of Sodium.J. Exp. Med., 57:775, 1933.

    Article  CAS  Google Scholar 

  8. Jackson, C. M.: The Effects of Inanition and Malnutrition upon Growth and Structure. Philadelphia, P. Blakiston’s Son & Co., 1925.

    Google Scholar 

  9. Hershey, J. M., and Soskin, S.: Substitution for Lecithin for Raw Pancreasin the Diet of the Depancreatized Dog.Amer. Jour. Physiol., 98:74, 1931.

    CAS  Google Scholar 

  10. Weech, A. A., Goettsch, E., and Reeves, E. B.: Nutritional Edema in the Dog. I. Development of Hypoproteinemia on a Diet Deficient in Protein.J. Exp. Med., 61:299, 1935.

    Article  CAS  Google Scholar 

  11. Weech, A. A.: Personal communication.

  12. Peters, J. P., and Van Slyke, D. D.: Quantitative Clinical Chemistry. Williams and Wilkins, Baltimore, Vol. 1, p. 243, p. 389, 1931.

    Google Scholar 

  13. Teorell, T.: Untersuchungen uber die Magnsaftsekretion.Skand. Arch. f. Phys., 66:226, 1933.

    Google Scholar 

  14. Elman, R., and Eckert, C. T.: Gastric Acidity as Influenced by Pyloric Closure and Stenosis.Arch. Surg., 29:1001, 1934.

    CAS  Google Scholar 

  15. Hoelzel, F., and DaCosta, E.: Production of Ulcer in Prostomach of Rats by Protein Restriction.Proc. Soc. Exp. Biol. Med., 29:383, 1932.

    Google Scholar 

  16. Rassers, R. F.: Die Pathogenese des Chronischen Magendarmgeschwures nebst einige Bemergungen zur Frage einer rationellen Therapie. Leiden, Van Doesburgh, 1926.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. New York, New York

    Charles A. Flood M.D. & Clinton R. Mullins M.D.

Authors
  1. Charles A. Flood M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Clinton R. Mullins M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

From the Departments of Medicine and Surgery, College of Physicians and Surgeons, Columbia University and the Presbyterian Hospital, New York City.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Flood, C.A., Mullins, C.R. Experimental peptic ulcer. American Journal of Digestive Diseases and Nutrition 3, 249–255 (1936). https://doi.org/10.1007/BF02999125

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02999125

Keywords

Search

Navigation