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The influence of Bact. coli and its products on the motility of strips of excised intestine

  • Experimental Physiology
  • Published:
The American Journal of Digestive Diseases

Summary and Conclusions

A substance (or substances) produced byBact. coli in peptone water cultures which exerts a definite influence on the motility of excised strips of intestine has been demonstrated. This substance depresses the motility of the duodenum and jejunum and stimulates that of the ileum and colon. It is detected readily in cultures after ten to fourteen days’ incubation.

The reactive material is present in the centrifuge supernatant and in filtrates of cultures ofBact. coli.

The reaction brought about by the culture material is reversible.

The reaction may be regarded as specific, since other bacteria,S. marcescens, B. subtilis, B. cereus, and B. mycoides, all of which are of non-intestinal origin, apparently do not produce substances which exert any definite action on the motility of the intestine.

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Authors and Affiliations

  1. New Haven, Connecticut

    Louis Weinstein & Leo F. Rettger

Authors
  1. Louis Weinstein
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  2. Leo F. Rettger
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Department of Bacteriology, Yale University.

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Weinstein, L., Rettger, L.F. The influence of Bact. coli and its products on the motility of strips of excised intestine. American Journal of Digestive Diseases and Nutrition 3, 224–228 (1936). https://doi.org/10.1007/BF02999119

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  • DOI: https://doi.org/10.1007/BF02999119

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