Summary
1. Under optimum conditions for tryptic activity, spleen and liver of the hog show no proteolysis.
2. Very small traces of trypsin added to these tissues under the same conditions give unequivocal evidence of proteolytic activity.
3. We have been unable therefore to find any evidence in support of the theory that trypsin is absorbed as such from the intestinal tract, to be distributed to and fixed by the tissues for their metabolic use.
4. Spleen and liver cells contain proteolytic enzymes not found in pancreatic juice and therefore not supplied them by absorption of that juice. It is logical to assume that they are produced by the tissue cells themselves, until definitely proven otherwise.
5. Any system of physiology, pathology, and therapy, based upon the assumption that pancreatic enzymes are regularly present in tissues such as liver and spleen, should be accepted with caution until some competent evidence is forthcoming to substantiate it.
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From the Laboratory of Physiological Chemistry, University of Wisconsin, Madison, Wisconsin.
This work was facilitated by the assistance of W. P. A. project fund of the University of Wisconsin.
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Bradley, H.C., Belfer, S. Pancreatic enzymes and tissue metabolism. American Journal of Digestive Diseases and Nutrition 3, 220–223 (1936). https://doi.org/10.1007/BF02999118
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DOI: https://doi.org/10.1007/BF02999118