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Histaminase: an experimental study

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The American Journal of Digestive Diseases

Summary

Histaminase had no depressant effect on the salivary, gastric, biliary and pancreatic secretion of dogs stimulated by histamine.

Histaminase had no depressant effect on gastric secretion of dogs following a meat meal.

Histaminase had no effect on gastric motility of dogs stimulated by insulin or prostigmine.

The effects of various preparations of Torantil were variable; in a number of experiments stimulation of gastric, biliary, or pancreatic secretion was observed.

Our experiments do not lend any support to the assumption that histaminase affects gastro-intestinal secretions stimulated by histamine.

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References

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Authors and Affiliations

  1. Department of Gastro-Intestinal Research, Michael Reese Hospital, Chicago, Illinois

    H. Necheles, WM. H. Olson & WM. Scruggs

Authors
  1. H. Necheles
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  2. WM. H. Olson
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  3. WM. Scruggs
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Additional information

Aided by the Rosalinda Klein fund.

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Necheles, H., Olson, W.H. & Scruggs, W. Histaminase: an experimental study. American Journal of Digestive Diseases 8, 217–219 (1941). https://doi.org/10.1007/BF02998405

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  • DOI: https://doi.org/10.1007/BF02998405

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