Abstract
The development of lung nodules from intravenously injected Walker 256 (W256) tumor cells was the model system for metastases formation in this experiment. The influence and inhibitory mechanisms of a syntheticPaeonia rubra 801 (P801) on occurrence of lung metastases were investigated. The results showed that treatment with P801 alone or in combination with decoction ofHuangqi (Astragalus root) can significantly reduce the number of lung nodules. The mechanisms responsible for decreased colonyforming potential in the rats treated with P801 were investigated. ADP-induced or W256 tumor cell-induced platelet aggregation was markedly inhibited by P801. It appears that inhibitory effect of P801 on occurrence of W256 tumor lung nodules is mainly due to reduced blood coagulability and inhibition of platelet activation by tumor cells.
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Yu, J., Hu, S., Li, X. et al. The effect ofPaeonia rubra 801 on the occurrence of lung metastases in walker 256 tumor. Chin J Cancer Res 5, 226–234 (1993). https://doi.org/10.1007/BF02997528
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DOI: https://doi.org/10.1007/BF02997528