Abstract
A chemosensitivity test for ovarian cancer using tritiated thymidine incorporation assay was carried out. A dose-response relationship for cisplatin and potentiation of verapamil in increasing vincristine inhibition to ovarian cancer were investigated. A 5-fold increase of cisplatin density converted the tumors which were initially resistance to standard-dose cisplatin into drug-sensitive ones. Verapamil was found to be able to overcome vincristine-resistance of some tumorsin vitro. These results suggest that using high dose cisplatin therapy or increasing local drug concentration by using other administration way, we could expect some ovarian cancers that had failed to standard dose cisplatin therapy to be effective. Combination of vincristine with verapamil may be helpful in treating some vincristineresistant cases.
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Lü, S., Gao, Y. & Shi, Y. A study of decreasing drug-resistance of human ovarian cancer cellsin vitro . Chin J Cancer Res 4, 73–78 (1992). https://doi.org/10.1007/BF02997514
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DOI: https://doi.org/10.1007/BF02997514