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Spontaneous variations in gastric secretion in response to histamine stimulation

  • Published:
The American Journal of Digestive Diseases

Conclusions

  1. 1.

    Although the gastric secretory curve in response to histamine is, in a given individual, quite constant as a rule, remarkable unexplained variations do occur.

  2. 2.

    “Histamine-proved” achlorhydria is not necessarily true anacidity. Great care is needed to exclude technical errors such as an incorrect location of the tip of the tube, excessive regurgitation of duodenal content, or the swallowing of saliva.

  3. 3.

    “Histamine-proved” achlorhydria is not necessarilypermanent anacidity, for transient refractoriness to histamine does occur. The cause of this phenomenon is not known.

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References

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Authors and Affiliations

  1. Department of Medicine, The University of Chicago, Chicago, Illinois

    Walter lincoln Palmer, Joseph B. Kirsner & Paul B. Nutter

Authors
  1. Walter lincoln Palmer
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  2. Joseph B. Kirsner
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  3. Paul B. Nutter
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Additional information

Read at the Annual Session of the American Gastro-Enterological Association, Atlantic City, N. J., June 10, 1940.

This case and those shown ,in Charts 3 and 5 were mentioned by Palmer, Walter Lincoln and Nutter, Paul B. : Peptic Ulcer and Achlorhydria. Arch. Int. Med., 65:499, 1940, in the addendum and as cases 2 and 3 respectively. Further details of the case shown in Chart 4 may be found in Palmer, Walter Lincoln ; Schindler, Rudolf, and Templeton, Frederic E. : The Development and Healing of Gastric Ulcer — A Clinical, Gastroscopic and Roentgenologic Study. Am. J. Dig. Dis., 5 :501, 1938.

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Palmer, W.l., Kirsner, J.B. & Nutter, P.B. Spontaneous variations in gastric secretion in response to histamine stimulation. Jour. D. D. 7, 427–431 (1940). https://doi.org/10.1007/BF02997389

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  • DOI: https://doi.org/10.1007/BF02997389

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