Conclusions
The above-reported experiments on dogs must be regarded as of a preliminary nature. However, they establish certain facts, viz.
-
(1)
Aluminum hydroxide, when introduced into the stomach, influences the secretion of gastric juice in a part of the gastric mucosa separated from the main stomach and forming a pouch. In other words, it actspar distance.
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(2)
Such an application produces a greater effect when given some time before a meal.
-
(3)
It has no harmful effect on the animal, even when administered in large doses. No general symptoms of poisoning nor any local unfavorable effects, such as constipation or vomiting for example, were ever observed in our animals.
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(4)
Aluminum, unlike the alkalis, produces as an after-effect an inhibition of gastric secretion rather than an increase.
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(5)
The peptic power of the gastric juice is greatly diminished not only when the juice comes into direct contact with Amphojel in the stomach, but also in the case of the secretion of the separate Pavlov-pouch when Amphojel is introduced into the main stomach. Our thanks are due to Professor B. P. Babkin, who supervised this work, and to John Wyeth & Brother, who furnished a supply of Amphojel.
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From the Department of Physiology, McGill University. Submitted November 5, 1939.
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Komarov, S.A., Krueger, L. The effect of aluminum hydroxide gel on gastric secretion in the dog. American Journal of Digestive Diseases 7, 170–175 (1940). https://doi.org/10.1007/BF02997170
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DOI: https://doi.org/10.1007/BF02997170