Skip to main content
SpringerLink
Log in

Cell-mediated immunity in upper respiratory tract cancer

  • Original Articles
  • Published:
Indian Journal of Otolaryngology Aims and scope Submit manuscript

Abstract

A study of cell-mediated immunological reactivity was made in 48 patients with upper respiratory tract cancer. Among the in vivo methods, primary reactivity was measured by contact sensitization to DNCB and secondary reactivity by contact sensitization to skin test antigen, PPD. The in vitro assay was the blastogenic response to the mitogen phytohaemagglutinin. In general there was an increased incidence of anergic and impaired reactivity in patients with cancer of upper respiratory tract compared to age-matched controls. A relationship between longevity of survival and the intensity of of delayed hypersensitivity response was also seen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gatti, R.A. & Good, R. (1971): Occurrence of malignancy in immuno deficiency diseases. Cancer,28: 89–98.

    Article  PubMed  CAS  Google Scholar 

  2. Smith, R.T. & Landy, M. (1970): In Immune Surveillance, Academic Press, New York, P. 412-Quoted by Khoo & Mackay (1974).

    Google Scholar 

  3. Trubowitz, S., Masck, B., & Del Rosario, A. (1966): Lymphocyte response to phytohaemagglutinin in Hodgkin’s disease,lymphatic Leukaemia and lymphosarcoma. Cancer,19: 2019–2023.

    Article  PubMed  CAS  Google Scholar 

  4. Smith, T.L., Cowling, D.E. & Barker, C.K. (1972):Response of lymphocytes in chronic lymphatic Leukaemia to mitogens. Lancet,1: 229–233.

    Article  PubMed  CAS  Google Scholar 

  5. Olsson, C.A., Rao, C.N., Menzoian, T.O. & Byrd, E.W. (1972): Immunologic unreactivity in bladder cancer patients.J. Urology,107: 607–609.

    CAS  Google Scholar 

  6. Lauder, I. & Bone, G. (1973): Lymphocyte transformation in large bowel cancer.British Journal of Cancer,27: 409–413.

    PubMed  CAS  Google Scholar 

  7. Khoo, S.K. & Mackay, E.V. (1974): Relation of cell mediated immunity in women with genital tract cancer to origin, history, clinical stage and subsequent behaviour of neoplasms.Journal of Obstetrics & Gynaecology of the British Commonwealth,81: 229–235.

    CAS  Google Scholar 

  8. Maisel, R.H. & Ogura, J.H. (1973): Abnormal dinitroch orobenzene skin sensitization: A Prognostic sign of survival in Head and Neck squamous cell carcinoma.The Laryngoscope,83: 2012–2019.

    Article  PubMed  CAS  Google Scholar 

  9. Bosworth, J.L., Ghossein, N.A. and and Brooks, T.L (1973): Correlation between delayed hypersensitivity and radiation responses in man.Radiology,107: 683–685.

    PubMed  CAS  Google Scholar 

  10. Catalona, W.T., Taylor, P.T., Rabson, A.S. & Chrstien, P.B. (1972): A method for dinitrochlorobenzene contact seniitization, a clinico pathological study:Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis. New Engl. J. Med.286: 399–402.

    PubMed  CAS  Google Scholar 

  11. Berlinger, N.T.,et al. (1976): Prognostic significance of lymph node histology in patients with squamous cell carcinoma of the larynx, pharynx, or oral cavity.The Laryngoscope 84: 792–803.

    Article  Google Scholar 

  12. Berlinger, N.T. and Good, R.A. (1976): Concomitant immunopathology with squamous cell carcinoma of the Head and Neck regions.Trans. Am. Acad. Ophthalyol. Otolaryngol.,82: ORL 588–594.

    CAS  Google Scholar 

  13. Berlinger, N.T.et. al. (1978): Deficient cell mediated immunity in Head and Neck cancer patients secondary to autologous suppressive immune cells.The Larynjoscope 88: 483.

    Google Scholar 

  14. Waksman, B.H. (1972): Measurement of cell mediated immunity.New Engl. J. Med. 286: 431–432.

    Article  PubMed  CAS  Google Scholar 

  15. Eilber, F.R., Morton, D.L., & Ketcham, A.S. (1974): Immunologic absnormalities in Head and Neck cancer-Amer. J. Surg. 128: 534–538.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. S. K. Sengupta

    Present address: Department of Pathology, Faculty of Medicine, University of Papua New Guinea, Boroko Post Office Box 5623, Papua, New Guinea

Authors and Affiliations

  1. Department of Pathology and Bacteriology, Institute ot Post Graduate Medical Education and Research, 20, Calcutta, India

    S. K. Sengupta, G. Talukdar & K. P. Sengupta

Authors
  1. S. K. Sengupta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Talukdar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. P. Sengupta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sengupta, S.K., Talukdar, G. & Sengupta, K.P. Cell-mediated immunity in upper respiratory tract cancer. Indian J Otolaryngol 36, 35–38 (1984). https://doi.org/10.1007/BF02993666

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02993666

Keywords

Search

Navigation