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The combined effect of high iron and zinc intake on copper status in rats

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Abstract

The interactions between copper, zinc, and iron intake in rats were investigated with regard to copper status. Weanling male rats were fed purified diets containing two levels of each of the three elements in a 23 factorial design. The added amounts of copper, zinc, and iron in the diets were 5, 12, and 35 mg/kg feed or were 10 times as high. After feeding on the experimental diets for 4 wk, the rats were killed and copper concentrations in plasma and organs measured. Plasma copper concentration was lowered by high zinc and iron intakes but this was seen only in the rats fed the normal-copper instead of the high-copper diets. In essence, the effects of zinc and iron were additive. Neither in rats fed the normal-copper diets nor in those fed the high-copper diets did extra iron or zinc intake alter copper concentrations in liver, spleen, kidney, and tibia.

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Authors and Affiliations

  1. Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands

    Shiguang Yu & Anton C. Beynen

  2. Department of Large Animal Medicine and Nutrition, Utrecht University, PO Box 80. 157, 3508 TD, Utrecht, The Netherlands

    Anton C. Beynen

Authors
  1. Shiguang Yu
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  2. Anton C. Beynen
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Yu, S., Beynen, A.C. The combined effect of high iron and zinc intake on copper status in rats. Biol Trace Elem Res 42, 71–79 (1994). https://doi.org/10.1007/BF02990490

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  • DOI: https://doi.org/10.1007/BF02990490

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