Abstract
A new non-invasive simple method for quantitative evaluation of thyroid was presented using graphical analysis of the transfer process of technetium-99m pertechnetate (99mTc) from the blood to thyroid. Thirty subjects were studied. After a bolus injection of 111 MBq of99mTc, the data were recorded on a 128×128 matrix as 60 frames of 1.5-second duration. ROIs were placed over the aortic arch and bilateral thyroid lobes. The activity of the aorta was monitored instead of the arterial activity. Graphical analysis by plottingB(t)/A(t) versus ∫ t0 A(τ)dτ/A(t) gave a straight line within the first 30 seconds in all subjects. The slope of the line was the unidirectional influx rate of99mTc (k u). Thyroid perfusion index (TPI) was calculated to standardize where the ratio of ROIthyroid size to ROIaorta size was set as 10.K u and TPI showed good correlation with99mTc thyroid uptake. Hyperthyroid patients showed high values ofk u and TPI. Considering that these indices were determined at the first pass of99mTc, this method may be helpful especially in the evaluation of thyroid perfusion.
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Okada, J., Higashitsuji, Y., Tamada, H. et al. Graphical analysis of99mTc thyroid scintigraphy. Ann Nucl Med 17, 235–238 (2003). https://doi.org/10.1007/BF02990027
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DOI: https://doi.org/10.1007/BF02990027