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The effect of ATP-sensitive K+ channels on the electrical burst activity and insulin secretion in pancreatic β-cells

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Abstract

In recent years, the electrical burst activity of the insulin releasing pancreatic β-cells has attracted many experimentalists and theoreticians, largely because of its functional importance, but also because of the nonlinear nature of the burst activity. The ATP-sensitive K+ channels are believed to play an important role in electrical activity and insulin release. In this paper, we show by computer simulation how ATP and antidiabetic drugs can lengthen the plateau fraction of bursting and how these chemicals can increase the intracellular Ca2+ level in the pancreatic β-cell.

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Authors and Affiliations

  1. University of Pittsburgh, 15260, Pittsburgh, PA

    Teresa Ree Chay & Jong Ryul Kim

  2. Division of Metabolism, Seattle VA Medical Center, 98108, Seattle, WA

    Daniel L. Cook

Authors
  1. Teresa Ree Chay
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  2. Jong Ryul Kim
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  3. Daniel L. Cook
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Chay, T.R., Kim, J.R. & Cook, D.L. The effect of ATP-sensitive K+ channels on the electrical burst activity and insulin secretion in pancreatic β-cells. Cell Biophysics 17, 11–36 (1990). https://doi.org/10.1007/BF02989802

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  • DOI: https://doi.org/10.1007/BF02989802

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