Abstract
Two methods of intestinal perfusion are described and used to study the effecs of alcohol on zinc absorption in the rat small intestine. The first method used perfusion of the lumen of the rat small intestinein situ without interruption of the vascular supply. During perfusion with a zinc-containing medium (with and without alcohol), alcohol was found to have no effect on net zinc uptake from the lumen of the intestine. However, there were significantly higher serum zinc concentrations recorded in the rats perfused wih the zinc and alcohol, 28.8 μmol/L, when compared with a group perfused without alcohol, 19.1 μmol/L (P < 0.01). The second method used simultaneous perfusion of the lumen of the rat small intestine, with constant-rate perfusion of the vascular bed with an artificial blood supply. In this experiment with a zinc-containing medium, with and without alcohol, there was no difference noted in zinc absorption from the lumen of the intestine, or release into the artificial blood supply. Therefore, in conclusion, alcohol does not appear to directly influence zinc absorption by the mucosal cells of the small intestine.
Similar content being viewed by others
References
B. L. Vallee, W. E. C. Wacker, A. F. Bartholomay, and E. D. Robin,N. Engl. J. Med. 255, 403 (1956).
B. L. Vallee, W. E. Wacker, A. F. Bartholomay, and F. L. Hoch,N. Engl. J. Med. 257, 1055 (1957).
J. F. Sullivan and H. G. Lankford,Am. J. Clin. Nutr. 17, 57 (1965).
A. D. Thomson and S. K. Majumdar, in Alcohol and the GI Tract, vol.10(2), C. M. Leevy, ed., 1981, pp. 263-294.
K. Weismann, J. Roed-Petersen, N. Hjorth, and H. Kopp,Int. J. Dermatol. 15, 757 (1976).
K. Weismann, H. Hoyer, and E. Christensen.Acta Dermato. Verier. (Stockholm)60, 447 (1980).
W. W. Dinsmore, D. McMaster, M. E. Callender, K. D. Buchanan, and A. H. G. Love,Irish J. Med. Sci. 153(1), 38 (1984).
P. J. Hanson and D. S. Parsons,J. Physiol. 225, 775 (1976).
D. McMaster, L. Steel, and A. H. G. Love, in J. McC Howell, J. M. Gawthorne and C. L. White,Proceedings of the Fourth International Symposium on Trace Element Metabolism in Man and Animals (TEMA-4), 1981, pp. 121–124.
D. McMaster, L. Steel and A. H. G. Love,Irish J. Med. Sci. 152, 329 (1983).
C. F. Chikosi, PhD Thesis, The Queen’s University of Belfast, 1982,
D. McMaster, T. R. J. Lappin, H. L. Hailiday, and C. C. Patterson,Biol. Neonate 44, 108 (1983).
F. A. Wilson and A. M. Hoyumpa,Gastroenterology 76, 388 (1979).
S. Kowarski, S. Blair-Stanek, and D. Schachter,Am. J. Physiol. 226(2), 401 (1974).
S. Gudbjarnason and A. S. Prasad, in Biochemical and Clinical Aspects of Alcohol Metabolism,V. M. Sardesa, Charles C Thomas, Springfield, Ill., 1969, pp. 266–272.
K. Markiewicz and M. Cholewa,J. Stud. Alcohol 43(7), 812 (1982).
C. E. Delgado, N. J. Fortuin, and R. S. Ross,Circulation 51, 535 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dinsmore, W.W., McMaster, D., Callender, M.E. et al. The effect of alcohol on zinc absorption. Biol Trace Elem Res 7, 241–253 (1985). https://doi.org/10.1007/BF02989249
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02989249
Index Entires
- Glucose absorption, and zinc
- lumen perfusion, and zinc absorption
- vascular perfusion, and zinc absorption
- perfusion, zinc absorption during vascular
- absorption, vascular perfusion and zinc
- zinc, absorption during vascular perfusion
- alcohol, effect on zinc absorption, rat, effect of alcohol on zinc absorption in