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Experimental radioimmunotherapy with186Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with131I-counterpart

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Abstract

A murine IgG1 against aMr 45 kD tumor-associated glycoprotein in human colorectal cancer, A7, was radiolabeled with186Re by a chelating method with a mercaptoacetyltriglycine (MAG3). Its specific activity was 119 MBq/mg, which would be high enough for a therapeutic purpose, and its immunoreactivity was preserved well as was131I-A7 labeled by the chloramine-T method. Growth of human colon cancer xenografts, 9.14±0.44 mm in diameter, in nude mice was significantly suppressed by an intravenous dose of 4.48 MBq of186Re-A7. The therapeutic outcome with186Re-A7 was better than that with 4.63 MBq of131I-A7. Toxicity of treatments assessed by body weight change was similar with both conjugates. These results are likely caused by the tumor size and more favorable physical properties of186Re than those of131I.

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Authors and Affiliations

  1. Production Division, Department of Research Reactor, Division of Radioisotopes, Japan Atomic Energy Research Institute, Japan

    Katsutoshi Kobayashi, Shoji Motoishi & Katsuyuki Onoma

  2. Department of Radiology, Toyama Medical and Pharmaceutical University, Toyama, Japan

    Naoto Watanabe

  3. Department of Radiology, Asahikawa Medical College, Asahikawa, Japan

    Noriyuki Shuke

  4. Medical Informatics, Kanazawa University Hospital, Kanazawa, Japan

    Hisashi Bunko

  5. Department of Nuclear Medicine, Kanazawa University School of Medicine, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan

    Seigo Kinuya, Kunihiko Yokoyama, Takatoshi Michigishi & Norihisa Tonami

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  1. Seigo Kinuya
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  2. Kunihiko Yokoyama
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  3. Katsutoshi Kobayashi
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  4. Shoji Motoishi
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  5. Katsuyuki Onoma
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  6. Naoto Watanabe
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  7. Noriyuki Shuke
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  8. Hisashi Bunko
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  9. Takatoshi Michigishi
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  10. Norihisa Tonami
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Correspondence to Seigo Kinuya.

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Kinuya, S., Yokoyama, K., Kobayashi, K. et al. Experimental radioimmunotherapy with186Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with131I-counterpart. Ann Nucl Med 15, 199–202 (2001). https://doi.org/10.1007/BF02987831

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  • DOI: https://doi.org/10.1007/BF02987831

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