Skip to main content
Log in

A case of small cell carcinoma of the esophagus detected incidentally by FDG-PET

  • Case Report
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Small cell carcinoma (SmC) of the esophagus is rare, and is sometimes impossible to detect by macroscopic inspection using an endoscope or histological examination of biopsied specimens. A 73-year-old man received F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) to evaluate the response to radiofrequency thermal ablation therapy for lung cancer. FDG-PET showed abnormal accumulation in the posterior mediastinum. Endoscopy disclosed ulcerous lesions with marginal elevation in the middle segment of the esophagus, but the biopsy specimen taken concurrently was not malignant histologically. FDG-PET, performed two months later, revealed abnormal accumulation in the suspect area, and the extent of accumulation was wider than previously. Histological examination of the specimen biopsied during the endoscopy led to a diagnosis of SmC. FDG-PET thus proved useful in the early detection of SmC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Beyer KL, Marshall JB, Dias-Arias AA, Loy TS. Primary small cell carcinoma of the esophagus. Report of 11 cases and review of the literature.J Clin Gastroenterol 1991; 13: 135–141.

    Article  PubMed  CAS  Google Scholar 

  2. McKeown F. Oat-cell carcinoma of the esophagus.J Pathol Bacteriol 1952; 64: 889–891.

    Article  PubMed  CAS  Google Scholar 

  3. Isolauri J, Mattila J, Kallioniemi OP. Primary undifferenti- ated small cell carcinoma of esophagus: clinicopathological and flow cytometric evaluation of eight cases.J Surg Oncol 1991; 46: 174–177.

    Article  PubMed  CAS  Google Scholar 

  4. Ishii H, Tatsuta M, Sano M, Okuda S, Taniguchi K, Ishiguro S. Endoscopic diagnosis and a trial of chemotherapy of small cell carcinoma of the esophagus.Gastroenterol Endosco 1984; 26: 1662–1670.

    Google Scholar 

  5. Takahashi T, Machida K, Honda N, Hosono M, Oku S, Osada H, et al. Extraosseous accumulation of99mTc-MDP in lymph node metastases of small cell carcinoma of the esophagus.Ann Nucl Med 2004; 18: 157–160.

    Article  PubMed  Google Scholar 

  6. Bennouna J, Bardet E, Degrial P, Douoilard Y. Small cell carcinoma of the esophagus: analysis of 10 cases and review of the published data.Am J Clin Oncol 2000; 23: 455–459.

    PubMed  CAS  Google Scholar 

  7. Medgyes DC, Wolff RA, Putman JB, Ajani JA. Small cell carcinoma of the esophagus: the University of Texas MD Anderson Cancer Center experience and literature review.Cancer 2000; 88: 262–267.

    Article  Google Scholar 

  8. Osugi H, Takemura M, Morimura K, Kaneko M, Higashino M, Takada N, et al. Clinicopathologic and immunohis- tochemical features of surgically resected small cell carcinoma of esophagus.Oncol Rep 2002; 9: 1245–1249.

    PubMed  Google Scholar 

  9. Mitani M, Kuwabara Y, Shinoda N, Sato A, Fujii Y. Long term survivors after the resection of limited esophageal small cell carcinoma.Dis Esophagus 2001; 13: 259–261.

    Article  Google Scholar 

  10. Yeung H, Macapinlac H, Mazumdar M, Bains M, Finn R, Larson S. FDG-PET in esophageal cancer: incidental value over computed tomography.Clin Positron Imaging 1999; 2: 255–260.

    Article  PubMed  Google Scholar 

  11. Choi JY, Lee KH, Shim YM, Lee KS, Kim JJ, Kim SE, et al. Improved detection of individual nodal involvement in squamous cell carcinoma of esophagus by FDG-PET.J Nucl Med 2000; 41: 808–815.

    PubMed  CAS  Google Scholar 

  12. Cook GJR, Fogelman I, Maisey MN. Normal physiological and benign pathological variants of 18-fluoro-2-deoxyglu- cose positron emission tomography scanning: potential for error in interpretation.Semin Nucl Med 1996; 16: 308–314.

    Article  Google Scholar 

  13. Koga H, Sasaki M, Kuwabara Y, Hirata K, Nakagawa M, Abe K, et al. An analysis of the physiological FDG uptake pattern in the stomach.Ann Nucl Med 2003; 17: 733–738.

    Article  PubMed  CAS  Google Scholar 

  14. Bakheet SM, Amin T, Alia AG, Kuzo R, Powe J. F-18 FDG uptake in benign esophageal disease.Clin Nucl Med 1999; 24: 995–97.

    Article  PubMed  CAS  Google Scholar 

  15. Yasuda S, Shohtsu A. Cancer screening with whole body F-18 fluorodeoxyglucose positron emission tomography.Lancet 1997; 350: 1819.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joji Kawabe.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Torii, K., Kawabe, J., Hayashi, T. et al. A case of small cell carcinoma of the esophagus detected incidentally by FDG-PET. Ann Nucl Med 18, 699–702 (2004). https://doi.org/10.1007/BF02985965

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02985965

Key words

Navigation