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Evaluation of myocardial viability following acute myocardial infarctic using201Tl SPECT after thallium-glucose-insulin infusion —Comparison with18F-FDG positron emission tomography—

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Abstract

Objective and Methods

The aim of this study was to evaluate myocardial viability in patients after acute myocardial infarction (AMI). We compared2O1T1 SPECT after2O1Tl with GIK (10% glucose 250ml, insulin 5 U and KCl 10 mEq) infusion (GIK-2O1T1) with resting2O1T1 and99mTc-pyrophosphate (PYP) dual SPECT, positron emission computed tomography (PET) using18F-fluorodeoxyglucose (18F-FDG) in 21 patients with their first AMI, who all underwent successful reperfusion. GIK-201Tl SPECT,201T1 and99mTc-PYP dual SPECT were done within 10 days after admission and18F-FDG-PET was performed at 3 weeks. GIK-201Tl SPECT was obtained after 30 min of GIK-201T1 infusion.18F-FDG (370 MBq) was injected intravenously after oral glucose (1 g/ kg) loading, and then PET was obtained. PET and SPECT images were divided into 20 segments. Regional tracer uptake was scored using a 4-point scoring system (3 = normal to 0 = defect), and summed to a regional uptake score (RUS). Regional area means the infarcted area in which99mTc-PYP accumulated. The number of decreased uptake segments (ES) was then determined. The infarcted area was defined as the area of99mTc-PYP uptake.

Results

The ESs for the GIK-201Tl and18F-FDG-PET images were significantly lower than the number of99mTc-PYP uptake segments. The RUS for GIK-2O1T1 was higher than that for resting-201Tl imaging and similar to those for18F-FDG-PET.

Conclusions

In the detection of myocardial viability following AMI, GIK-2O1T1 imaging is useful with findings similar to those of18F-FDG-PET.

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Authors and Affiliations

  1. Gunma Prefectural Cardiovascular Center, 3-12 Kameizumi-machi, 371-0004, Maebashi, Gunma, Japan

    Takuji Toyama, Hiroshi Hoshizaki, Ryotaro Seki, Naoki Isobe, Shigeru Oshima & Koichi Taniguchi

  2. Gunma University School of Medicine, Japan

    Kyosuke Higuchi, Hidenori Seki, Takashi Hatori, Masahiko Kurabayashi & Keigo Endo

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  1. Takuji Toyama
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  2. Hiroshi Hoshizaki
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Correspondence to Takuji Toyama.

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Toyama, T., Hoshizaki, H., Seki, R. et al. Evaluation of myocardial viability following acute myocardial infarctic using201Tl SPECT after thallium-glucose-insulin infusion —Comparison with18F-FDG positron emission tomography—. Ann Nucl Med 18, 463–468 (2004). https://doi.org/10.1007/BF02984561

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  • DOI: https://doi.org/10.1007/BF02984561

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