Conclusions
1. The majority of pathological genes in man:
-
(a)
are conditionally dominant, showing a definite expression in the heterozygote, and
-
(b)
have poor penetrance. This is true both for autosomal as well as for sex-linked genes.
2. Conditionally dominant genes (in the heterozygote) tend to be expressed later in ontogeny than recessive genes (in the homozygote).
3. An explanation is given for these phenomena from the point of view of the evolution of dominance.
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References
Ardashnikov, S. N. (1934). “On the genetics of leukaemia.”Proc. Maxim Gorky Med.-Biol. Res. Inst. 3. (Russian with an English summary.)
Baur, Fischer & Lenz (1927).Menschliche Erblichkeitslehre,1,iii. Aufl.
Bulloch, W. (1909). “Diabetes insipidus.”Treasury of Human Inheritance,1, partsi–ii.
Davenport, C. B. (1930). “Sex linkage in man.”Genetics,15, No. 5.
Davidenkov, S. N. (1932).Hereditary Diseases of the Nervous System. Moscow. (Russian.)
Engelhard, C. F. (1915). “Eine Familie mit hereditärem Nystagmus.”Z. ges. Neurol. Psychiat. 28.
Fisher, R. A. (1928). “The possible modification of the response of the wild type to recurrent mutations.”Am. Nat. 62, 115–126.
-- (1930).The Genetical Theory of Natural Selection. Oxford.
-- (1931). “The evolution of dominance.”Biol. Rev. 6, No. 4.
Franceschetti, A. (1930). “Die Vererbung von Augenleiden.”Kurz. Handbuch d. Ophthalmologie,1, herausg. von Schieck und Brückner.
Frank-Kamentzky, S. O. (1927). “On a peculiar hereditary form of glaucoma in Irkutsk district.”Rus. Eug. J., v, No. 1. (Russian.)
Freidberg, S. A. (1930). “Über Nachforschungen von Blutungserscheinungen bei Frauen, die Heterozygoten des Gens Haemophilie sind.”Med.-biol. J., Moscow, Nos. 4–5. (Russian with a German summary.)
Gassko, S. M. (1936). “A clinico-genetical investigation of paroxysmal tachycardia.”Proc. Maxim Gorky Med.-Gen. Res. Inst. 4 (in the Press).
Grönholm, V. (1921). “Über die Vererbung der Megalocornea u.s.w.”Kl. Monatsbl. f. Augenh. 67, 1.
Haldane, J. B. S. (1930). “A note on Fisher’s theory of the origin of dominance and on a correlation between dominance and linkage.”Amer. Nat. 64, 87.
Hemmes, G. D. (1924). “Over ‘hereditary nystagmus’.” Diss. Utrecht.
Hogben, Lancelot (1932).Genetic Principles in Medicine and Social Science, p. 44. New York.
-- (1933).Nature and Nurture, p. 51. London.
Huskins, C. Leonard (1930). “On the inheritance of an anomaly of human dentition.”J. Hered. No. 6.
Kayser, B. (1914). “Über den Stammbaum einer Familie mit Vererbung von Megalocornea nach dem Hornerschen Vererbungstypus.”Arch. Rass.- u. GesBiol. 11, 170.
Kleiner, Wilhelm (1923). “Über den grossen schweizerischen Stammbaum, in dem sich mit Kurzsichtigkeit kombinierte Nachtblindheit forterbt.” Ibid.15, 1.
Lenz, F. (1932). “Über den Geschlechtsgebundheit des erblichen Augenzitterns.”Ibid. 26.
Levin, A. E. &Kuchur, B. A. (1934). “The role of hereditary factors in the etiology of ulcerous disease.”Proc. Maxim Gorky Med.-Biol. Res. Inst. 3 (Russian with an English summary.)
Levit, S. G. (1929). “Genetics and pathology.”Med.-biol. J., Moscow, No. 5. (Russian.)
Levit, S. G. &Pessikova, L. N. (1934). “The genetics of diabetes mellitus.”Proc. Maxim Gorky Med.-Gen. Res. Inst. 3. (Russian with an English summary.)
-- -- (1936). “Is diabetes insipidus caused by a good dominant gene?”Ibid. 4 (in the Press).
Levit, S. G.,Ryvkin, J. A.,Sereisky, M. J.,Vogelson, L. I.,Dorfmann, I. A. &Likhziemr, I. B. (1930). “Über die Genetik der Basedowschen Krankheit und der ihr nahestehenden pathologischen Formen.”Med.-biol. J., Moscow, Nos. 4–5. (Russian with a German summary.)
Likhziemr, I. B.,Zhislina, S. G. &Gerchikova, J. A. (1936). “A clinico-genetical investigation of eunuchoidism” (in the Press).
McQuarrie, Margaret D. (1935). “Two pedigrees of hereditary blindness in man.”J. Genet. 30, No. 1.
Malkova, N. N. (1936). “Clinico-genetical investigation of bronchial asthma and other allergic diseases.”Proc. Maxim Gorky Med.-Gen. Res. Inst. 4 (in the Press).
Muller, H. J. (1932). “Further studies on the nature and causes of gene mutations.”Proc. VI Intern. Congr. Genet. 1.
Orel, Herbert (1929). “Die Vererbung von Ichthyosis congenita und der Ichthyosis vulgaris.”Z. Kinderheilk. 47, 32.
Plunkett, C. R. (1933). “A contribution to the theory of dominance.”Amer. Nat. 67, 84.
Presnyakov, D. F. (1936). “Clinico-genetical investigation of pernicious anaemia.”Proc. Maxim Gorky Med.-Gen. Res. Inst. 4 (in the Press).
Roberts, Elmer (1929). “The inheritance of anhydrosis associated with anadontia.”J. Amer. med. Ass. 93, No. 4.
Ryvkin, I. A. (1934). “On the heredity in paroxysmal tachycardia.”Proc. Maxim Gorky Med.-Biol. Res. Inst. 3. (Russian with an English summary.)
Schlössmann, H. (1930).Die Hämophilie. Stuttgart.
Siemens, Hermann Werner (1925). “Über einen in der menschlichen Pathologie noch nicht beobachteten Vererbungsmodus: dominante geschlechtsgebundene Vererbung.”Arch. Rass.- u. GesBiol. 17.
-- (1929). “Die Vererbung in der Ätiologie der Hautkrankheiten.”Handb. d. Haut- und Geschlechtskrankheiten,3, herausg. von J. Jadassohn.
Thadani, K. I. (1921). “A toothless type of man.”J. Hered. 12, 87.
—— (1934). “The toothless man of Sind.”J. Hered. 25, 483.
Varelmann, Hans (1925). “Die Vererbung der Hemeralopie mit Myopie.”Arch. Augenheilk. 96, 385.
Verschuer, Otmar (1934).Erbpathologie. Dresden und Leipzig.
Waardenburg, P. J. (1932). “Das menschliche Auge und seine Erbanlagen.”Bibliogr. Genet. 9.
Wieland, Max (1933). “Untersuchungen über Farbenschwäche bei Konduktorinen.”Graefe’s Arch. Ophthal. 130, 144.
Wright, Sewall (1934). “Physiological and evolutionary theories of dominance.”Amer. Nat. 68.
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Levit, S.G. The problem of dominance in man. Journ. of Genetics 33, 411–434 (1936). https://doi.org/10.1007/BF02982897
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DOI: https://doi.org/10.1007/BF02982897