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The inheritance of the immobilization antigens ofParamecium Aurelia, variety 2

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Summary

  1. 1.

    The inheritance of antigens which produce immobilizing antibodies has been studied inParamecium aurelia, variety 2. A single gene can control the ability to manifest an antigen. The appearance of one of two alternative cross-reactive antigens is also controlled by a single factor. The stability and titres of theF 1 clones of a cross between two homologous serotypes and the variation in the appearance of the serotype of such genotypically identical clones were examined.

  2. 2.

    The cytoplasm has an influence on the appearance of the immobilizing antigens in exconjugants of crosses between animals of similar serotypes and, especially, diverse serotypes. The influence of the parental serotype in crosses between cross-reacting serotypes may persist for as long as twenty postconjugation fissions, but in the majority of instances disappears within a few fissions. In contrast, when paramenia of the same genotypes but diverse serotypes are crossed, the parental serotype may persist indefinitely.

  3. 3.

    The persistence of a hybrid phenotype inF 2 generation animals presumed to be homozygous is probably due to nuclear abnormalities which ensure the maintenance of a heterozygous genotype, rather than to the action of cytoplasmic particles.

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Author notes

  1. Irving Finger

    Present address: Departments of Neurology and Microbiology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

Authors and Affiliations

  1. Zoological Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania

    Irving Finger

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  1. Irving Finger
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Submitted in partial fulfilment of the requirements for the Ph.D. Degree of the University of Pennsylvania.

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Finger, I. The inheritance of the immobilization antigens ofParamecium Aurelia, variety 2. J Genet 55, 361–374 (1957). https://doi.org/10.1007/BF02981649

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