Abstract
Chlorpheniramine (CPA) is an antihistaminic that changes the conformation of DNA and inhibits polyamine biosynthesis in mammalian cells. In the present work, we tested the effect of CPA on four genera of fungi species (Altemaria alternata, Botrytis cinerea, Cladosporium cladosporioides and threePenicillium spp.) grownin vitro. Similar growth inhibitions of these genera were produced by 0.5 raM iprodione, CPA and histidinol, but CPA was the most effective. The CPA sensitivities of the twoB. cinerea strains were different. Putrescine did not restore the fungal growth inhibited by CPA.
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Torés, J.A., González, M.D., Pozo, E. et al. The antihistaminic chlorpheniramine inhibitsin vitro growth of several fungi isolated from harvested fruits. Phytoparasitica 27, 207–213 (1999). https://doi.org/10.1007/BF02981460
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DOI: https://doi.org/10.1007/BF02981460