Abstract
New hypolipaemic agents, in which substituted indazole nucleus is connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to show significant inhibitory activity against microsomal HMG-CoA reductase in rat liver.
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Kim, JI., Jahng, Y. Synthesis and biological activity of indazole-derived HMG-CoA reductase inhibitors. Arch. Pharm. Res. 18, 206–212 (1995). https://doi.org/10.1007/BF02979197
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DOI: https://doi.org/10.1007/BF02979197